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HAMAP rule MF_03004

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General rule information [?]

Accession MF_03004
Dates 4-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 18)
Name eIF3e
Scope(s) Eukaryota
Template(s) P60228 (EIF3E_HUMAN); P60229 (EIF3E_MOUSE); O94513 (EIF3E_SCHPO); Q6DRI1 (EI3EA_DANRE); [ Recover all ]
Triggered by HAMAP; MF_03004 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier EIF3E
case <OC:Mammalia>
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit E;
                 Short=eIF3e;
AltName: Full=Eukaryotic translation initiation factor 3 subunit 6;
AltName: Full=eIF-3 p48;
else case <OC:Fungi>
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit E;
                 Short=eIF3e;
else
Protein name RecName: Full=Eukaryotic translation initiation factor 3 subunit E;
                 Short=eIF3e;
AltName: Full=Eukaryotic translation initiation factor 3 subunit 6;
end case
case <OC:Mammalia>
Gene name Name=EIF3E; Synonyms=EIF3S6, INT6;
else case <OC:Vertebrata> and not <OC:Mammalia>
Gene name Name=EIF3E; Synonyms=EIF3S6;
else case <OC:Caenorhabditis>
Gene name Name=eif-3.E;
else case <OC:Drosophilidae>
Gene name Name=eIF3e; Synonyms=eIF3-S6, Int6;
else case <OC:Fungi>
Gene name Name=INT6;
end case

Comments [?]

case <OC:Mammalia>
FUNCTIONComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
else
FUNCTIONComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
end case
case <OC:Mammalia>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
else case <OC:Vertebrata> and not <OC:Mammalia>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M).
else case <OC:Drosophilidae>
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix.
else
SUBUNITComponent of the eukaryotic translation initiation factor 3 (eIF-3) complex.
end case
case <OC:Mammalia>
SUBCELLULAR LOCATIONCytoplasm. Nucleus. Nucleus, PML body.
else case <OC:Vertebrata> and not <OC:Mammalia>
SUBCELLULAR LOCATIONCytoplasm. Nucleus.
else
SUBCELLULAR LOCATIONCytoplasm.
end case
case <OC:Mammalia>
PTMPhosphorylated upon DNA damage, probably by ATM or ATR.
end case
SIMILARITYBelongs to the eIF-3 subunit E family.

Keywords [?]

Cytoplasm
Initiation factor
Protein biosynthesis
case <FTTag:acetyl>
Acetylation
end case
case <OC:Vertebrata>
Nucleus
end case
case <OC:Mammalia>
Phosphoprotein
end case

Gene Ontology [?]

GO:0003743; Molecular function:translation initiation factor activity
GO:0001732; Biological process:formation of cytoplasmic translation initiation complex
GO:0002183; Biological process:cytoplasmic translational initiation
GO:0005737; Cellular component:cytoplasm
case <OCellular component:Vertebrata>
GO:0005634; Cellular component:nucleus
end case
GO:0071540; Cellular component:eukaryotic translation initiation factor 3 complex, eIF3e
GO:0016282; Cellular component:eukaryotic 43S preinitiation complex
GO:0033290; Cellular component:eukaryotic 48S preinitiation complex

Cross-references [?]

Pfam PF01399; PCI; 1;
PROSITE PS50250; PCI; 1;

Features [?]

From: EIF3E_HUMAN (P60228)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia>
INIT_MET 1 1 /note="Removed" M
REGION 4 128 /note="Sufficient for interaction with EPAS1"
REGION 9 195 /note="Sufficient for interaction with TRIM27"
REGION 351 445 /note="Sufficient for interaction with MCM7"
MOD_RES 2 2 /note="N-acetylalanine" acetyl A
end case

Additional information [?]

Size range 357-601 amino acids
Related rules None
Fusion Nter: None Cter: None



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