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Annotation rule MF_03004 |
General rule information
[?]
Accession |
MF_03004 |
Dates |
4-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 18) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit E;
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Short=eIF3e;
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AltName:
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Full=Eukaryotic translation initiation factor 3 subunit 6;
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AltName:
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Full=eIF-3 p48;
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|
else case <OC:Fungi>
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit E;
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Short=eIF3e;
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else
Protein name |
RecName:
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Full=Eukaryotic translation initiation factor 3 subunit E;
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Short=eIF3e;
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AltName:
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Full=Eukaryotic translation initiation factor 3 subunit 6;
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|
end case
case <OC:Mammalia>
else case <OC:Vertebrata> and not <OC:Mammalia>
else case <OC:Caenorhabditis>
else case <OC:Drosophilidae>
else case <OC:Fungi>
end case
case <OC:Mammalia>
Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. |
else
Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. |
end case
case <OC:Mammalia>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: @gn(EIF3A), @gn(EIF3B), @gn(EIF3C), @gn(EIF3D), @gn(EIF3E), @gn(EIF3F), @gn(EIF3G), @gn(EIF3H), @gn(EIF3I), @gn(EIF3J), @gn(EIF3K), @gn(EIF3L) and @gn(EIF3M). |
else case <OC:Drosophilidae>
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. The eIF-3 complex interacts with pix. |
else
Subunit |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex. |
end case
case <OC:Mammalia>
Subcellular location |
Cytoplasm. Nucleus. Nucleus, PML body. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Subcellular location |
Cytoplasm. Nucleus. |
else
Subcellular location |
Cytoplasm. |
end case
case <OC:Mammalia>
Ptm |
Phosphorylated upon DNA damage, probably by ATM or ATR. |
end case
Similarity |
Belongs to the eIF-3 subunit E family. |
case <FTTag:acetyl>
end case
case <OC:Vertebrata>
end case
case <OC:Mammalia>
end case
GO:0003743; Molecular function: translation initiation factor activity.
GO:0001732; Biological process: formation of cytoplasmic translation initiation complex.
GO:0002183; Biological process: cytoplasmic translational initiation.
GO:0005737; Cellular component: cytoplasm.
case <OC:Vertebrata>
end case
GO:0071540; Cellular component: eukaryotic translation initiation factor 3 complex, eIF3e.
GO:0016282; Cellular component: eukaryotic 43S preinitiation complex.
GO:0033290; Cellular component: eukaryotic 48S preinitiation complex.
case <OC:Mammalia>
From: EIF3E_HUMAN (P60228) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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INIT_MET
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1
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1
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Removed
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M
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REGION
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4
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128
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Sufficient for interaction with EPAS1
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REGION
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9
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195
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Sufficient for interaction with TRIM27
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REGION
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351
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445
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Sufficient for interaction with MCM7
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MOD_RES
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2
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2
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N-acetylalanine
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acetyl
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A
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end case
Additional information
[?]
Size range |
357-601 amino acids |
Related rules |
None |
Fusion |
None |