HAMAP rule MF_03020
General rule information
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| Accession | MF_03020 |
| Dates | 12-FEB-2009 (Created)
23-MAY-2024 (Last updated, Version 18) |
| Name | T23O_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P48775 (T23O_HUMAN); P48776 (T23O_MOUSE); P21643 (T23O_RAT); Q17P71 (T23O_AEDAE); P20351 (T23O_DROME); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01972 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | T23O |
| case <OC:Drosophilidae> | |
| Protein name | RecName: Full=Tryptophan 2,3-dioxygenase; Short=TDO; EC=1.13.11.11; AltName: Full=Protein vermilion; AltName: Full=Tryptamin 2,3-dioxygenase; AltName: Full=Tryptophan oxygenase; Short=TO; Short=TRPO; AltName: Full=Tryptophan pyrrolase; AltName: Full=Tryptophanase; |
| else | |
| Protein name | RecName: Full=Tryptophan 2,3-dioxygenase; Short=TDO; EC=1.13.11.11; AltName: Full=Tryptamin 2,3-dioxygenase; AltName: Full=Tryptophan oxygenase; Short=TO; Short=TRPO; AltName: Full=Tryptophan pyrrolase; AltName: Full=Tryptophanase; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=TDO2; |
| else case <OC:Dictyostelium> | |
| Gene name | Name=tdo; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=v; |
| end case | |
Comments
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| FUNCTION | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. |
| CATALYTIC ACTIVITY | Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11; |
| COFACTOR | Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.; |
| PATHWAY | Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. |
| case <OC:Insecta> | |
| PATHWAY | Pigment biosynthesis; ommochrome biosynthesis. |
| end case | |
| SUBUNIT | Homotetramer. Dimer of dimers. |
| SIMILARITY | Belongs to the tryptophan 2,3-dioxygenase family. |
Keywords
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Gene Ontology
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| GO:0004833; Molecular function:tryptophan 2,3-dioxygenase activity | |
| GO:0020037; Molecular function:heme binding | |
| GO:0019441; Biological process:tryptophan catabolic process to kynurenine | |
| case <OCellular component:Insecta> | |
| GO:0006727; Biological process:ommochrome biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF03301; Trp_dioxygenase; 1; |
| PROSITE | PS50312; ASP_RICH; 0-unlimited; |
| PROSITE | PS50313; GLU_RICH; 0-unlimited; |
| PROSITE | PS50318; LYS_RICH; 0-unlimited; |
| PROSITE | PS50323; ARG_RICH; 0-unlimited; |
Features
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| From: T23O_HUMAN (Q8PDA8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 72 | 76 | /ligand="substrate" | F-[IV]-[IVT]-[IVQT]-H | ||||||||
| BINDING | 328 | 328 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue" |
H | ||||||||
| BINDING | 144 | 144 | /ligand="substrate" | R | ||||||||
| BINDING | 342 | 342 | /ligand="substrate" | T | ||||||||
Additional information
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| Size range | 260-412 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |