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HAMAP rule MF_03020

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General rule information [?]

Accession MF_03020
Dates 12-FEB-2009 (Created)
23-MAY-2024 (Last updated, Version 18)
Name T23O_euk
Scope(s) Eukaryota
Template(s) P48775 (T23O_HUMAN); P48776 (T23O_MOUSE); P21643 (T23O_RAT); Q17P71 (T23O_AEDAE); P20351 (T23O_DROME); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_01972 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier T23O
case <OC:Drosophilidae>
Protein name RecName: Full=Tryptophan 2,3-dioxygenase;
                 Short=TDO;
                 EC=1.13.11.11;
AltName: Full=Protein vermilion;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
                 Short=TO;
                 Short=TRPO;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
else
Protein name RecName: Full=Tryptophan 2,3-dioxygenase;
                 Short=TDO;
                 EC=1.13.11.11;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
                 Short=TO;
                 Short=TRPO;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
end case
case <OC:Vertebrata>
Gene name Name=TDO2;
else case <OC:Dictyostelium>
Gene name Name=tdo;
else case <OC:Drosophilidae>
Gene name Name=v;
end case

Comments [?]

FUNCTIONHeme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
CATALYTIC ACTIVITY Reaction=L-tryptophan + O2 = N-formyl-L-kynurenine; Xref=Rhea:RHEA:24536, ChEBI:CHEBI:15379, ChEBI:CHEBI:57912, ChEBI:CHEBI:58629; EC=1.13.11.11;
COFACTOR Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 1 heme group per subunit.;
PATHWAYAmino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
case <OC:Insecta>
PATHWAYPigment biosynthesis; ommochrome biosynthesis.
end case
SUBUNITHomotetramer. Dimer of dimers.
SIMILARITYBelongs to the tryptophan 2,3-dioxygenase family.

Keywords [?]


Gene Ontology [?]

GO:0004833; Molecular function:tryptophan 2,3-dioxygenase activity
GO:0020037; Molecular function:heme binding
GO:0019441; Biological process:tryptophan catabolic process to kynurenine
case <OCellular component:Insecta>
GO:0006727; Biological process:ommochrome biosynthetic process
end case

Cross-references [?]

Pfam PF03301; Trp_dioxygenase; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PROSITE PS50313; GLU_RICH; 0-unlimited;
PROSITE PS50318; LYS_RICH; 0-unlimited;
PROSITE PS50323; ARG_RICH; 0-unlimited;

Features [?]

From: T23O_HUMAN (Q8PDA8)
Key From To Description Tag Condition FTGroup
BINDING 72 76 /ligand="substrate" F-[IV]-[IVT]-[IVQT]-H
BINDING 328 328 /ligand="heme"
/ligand_id="ChEBI:CHEBI:30413"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"
H
BINDING 144 144 /ligand="substrate" R
BINDING 342 342 /ligand="substrate" T

Additional information [?]

Size range 260-412 amino acids
Related rules None
Fusion Nter: None Cter: None



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