HAMAP rule MF_03020
General rule information
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Accession | MF_03020 |
Dates | 12-FEB-2009 (Created) 19-NOV-2022 (Last updated, Version 16) |
Name | T23O_euk |
Scope | Eukaryota |
Templates | P48775 (T23O_HUMAN); P48776 (T23O_MOUSE); P21643 (T23O_RAT); Q17P71 (T23O_AEDAE); P20351 (T23O_DROME): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Drosophilidae>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Dictyostelium>
Gene name |
|
else case <OC:Drosophilidae>
Gene name |
|
end case
Comments
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Function | Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. |
Catalytic activity | RHEA:24536: L-tryptophan + O2 = N-formyl-L-kynurenine
EC 1.13.11.11 |
Cofactor | heme Note: Binds 1 heme group per subunit. |
Pathway | Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. |
case <OC:Insecta>
Pathway | Pigment biosynthesis; ommochrome biosynthesis. |
end case
Subunit | Homotetramer. Dimer of dimers. |
Similarity | Belongs to the tryptophan 2,3-dioxygenase family. |
Keywords
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Gene Ontology
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GO:0004833; Molecular function: tryptophan 2,3-dioxygenase activity.
GO:0020037; Molecular function: heme binding.
GO:0006569; Biological process: tryptophan catabolic process.
GO:0020037; Molecular function: heme binding.
GO:0006569; Biological process: tryptophan catabolic process.
Cross-references
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Pfam | PF03301; Trp_dioxygenase; 1; |
PROSITE | PS50312; ASP_RICH; 0-unlimited; |
PS50313; GLU_RICH; 0-unlimited; | |
PS50318; LYS_RICH; 0-unlimited; | |
PS50323; ARG_RICH; 0-unlimited; |
Features
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From: T23O_HUMAN (Q8PDA8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 72 | 76 | /ligand="substrate | F-[IV]-[IVT]-[IVQT]-H | ||||||||
BINDING | 328 | 328 | /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue | H | ||||||||
BINDING | 144 | 144 | /ligand="substrate | R | ||||||||
BINDING | 342 | 342 | /ligand="substrate | T |
Additional information
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Size range | 260-412 amino acids |
Related rules | None |
Fusion | None |