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HAMAP rule MF_03020

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General rule information [?]

Accession MF_03020
Dates 12-FEB-2009 (Created)
19-NOV-2022 (Last updated, Version 16)
Name T23O_euk
Scope
Eukaryota
Templates P48775 (T23O_HUMAN); P48776 (T23O_MOUSE); P21643 (T23O_RAT); Q17P71 (T23O_AEDAE); P20351 (T23O_DROME): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
T23O
case <OC:Drosophilidae>
Protein name
RecName: Full=Tryptophan 2,3-dioxygenase;
Short=TDO;
EC 1.13.11.11;
AltName: Full=Protein vermilion;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
Short=TO;
Short=TRPO;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
else
Protein name
RecName: Full=Tryptophan 2,3-dioxygenase;
Short=TDO;
EC 1.13.11.11;
AltName: Full=Tryptamin 2,3-dioxygenase;
AltName: Full=Tryptophan oxygenase;
Short=TO;
Short=TRPO;
AltName: Full=Tryptophan pyrrolase;
AltName: Full=Tryptophanase;
end case
case <OC:Vertebrata>
Gene name
TDO2
else case <OC:Dictyostelium>
Gene name
tdo
else case <OC:Drosophilidae>
Gene name
v
end case

Comments [?]

Function Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.
Catalytic activity RHEA:24536: L-tryptophan + O2 = N-formyl-L-kynurenine
EC 1.13.11.11
Cofactor heme
Note: Binds 1 heme group per subunit.
Pathway Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
case <OC:Insecta>
Pathway Pigment biosynthesis; ommochrome biosynthesis.
end case
Subunit Homotetramer. Dimer of dimers.
Similarity Belongs to the tryptophan 2,3-dioxygenase family.

Keywords [?]

Dioxygenase
Heme
Iron
Metal-binding
Oxidoreductase
Tryptophan catabolism

Gene Ontology [?]

GO:0004833; Molecular function: tryptophan 2,3-dioxygenase activity.
GO:0020037; Molecular function: heme binding.
GO:0006569; Biological process: tryptophan catabolic process.

Cross-references [?]

Pfam PF03301; Trp_dioxygenase; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PS50313; GLU_RICH; 0-unlimited;
PS50318; LYS_RICH; 0-unlimited;
PS50323; ARG_RICH; 0-unlimited;

Features [?]

From: T23O_HUMAN (Q8PDA8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     72     76       /ligand="substrate     F-[IV]-[IVT]-[IVQT]-H  
BINDING     328     328       /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue     H  
BINDING     144     144       /ligand="substrate     R  
BINDING     342     342       /ligand="substrate     T  

Additional information [?]

Size range 260-412 amino acids
Related rules None
Fusion None


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