HAMAP rule MF_03026

General rule information [?]

Accession	MF_03026
Dates	3-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 12)
Name	LZTS2
Scope(s)	Eukaryota Vertebrata
Template(s)	Q9BRK4 (LZTS2_HUMAN); Q3LUD4 (LZTS2_RAT); [ Recover all ]
Triggered by	HAMAP; MF_03026 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LZTS2
case <OC:Mammalia>
Protein name	RecName: Full=Leucine zipper putative tumor suppressor 2; AltName: Full=Protein LAPSER1;
else
Protein name	RecName: Full=Leucine zipper putative tumor suppressor 2 homolog; AltName: Full=Protein @gn(LAPSER1);
end case
Gene name	Name=LZTS2; Synonyms=LAPSER1;

Comments [?]

case <OC:Mammalia>
FUNCTION	Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin.
else
FUNCTION	Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
end case
case <OC:Mammalia>
SUBUNIT	Interacts with KATNB1. Also interacts with CTNNB1, gamma- tubulin and KIF23.
end case
case <OC:Mammalia>
SUBCELLULAR LOCATION	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
else
SUBCELLULAR LOCATION	Cytoplasm. Cytoplasm, cytoskeleton, centrosome.
end case
SIMILARITY	Belongs to the LZTS2 family.

Keywords [?]

Gene Ontology [?]

GO:0051013; Biological process:microtubule severing

GO:0000281; Biological process:mitotic cytokinesis

GO:0030178; Biological process:negative regulation of Wnt signaling pathway

GO:0051168; Biological process:nuclear export

GO:0051255; Biological process:spindle midzone assembly

GO:0005737; Cellular component:cytoplasm

GO:0005813; Cellular component:centrosome

GO:0030496; Cellular component:midbody

Cross-references [?]

Features [?]

From: LZTS2_HUMAN (Q9BRK4)

Key

From

Description

Tag

Condition

FTGroup

case <OC:Mammalia>

MOTIF

631

640

/note="Nuclear export signal"

L-x-x-x-L-x-x-L-x-L

end case

Additional information [?]