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Annotation rule MF_03026
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General rule information [?]

Accession MF_03026
Dates 3-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 12)
Name LZTS2
Scope
Eukaryota; Vertebrata
Templates Q9BRK4 (LZTS2_HUMAN); Q3LUD4 (LZTS2_RAT): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LZTS2
case <OC:Mammalia>
Protein name
RecName: Full=Leucine zipper putative tumor suppressor 2;
AltName: Full=Protein LAPSER1;
else
Protein name
RecName: Full=Leucine zipper putative tumor suppressor 2 homolog;
AltName: Full=Protein @gn(LAPSER1);
end case
Gene name
LZTS2, LAPSER1

Comments [?]

case <OC:Mammalia>
Function Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
else
Function Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
end case
case <OC:Mammalia>
Subunit Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
end case
case <OC:Mammalia>
Subcellular location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
else
Subcellular location Cytoplasm. Cytoplasm, cytoskeleton, centrosome.
end case
Similarity Belongs to the LZTS2 family.

Keywords [?]

Cell cycle
Cell division
Cytoplasm
Cytoskeleton
Microtubule
Mitosis
Wnt signaling pathway

Gene Ontology [?]

GO:0051013; Biological process: microtubule severing.
GO:0000281; Biological process: mitotic cytokinesis.
GO:0030178; Biological process: negative regulation of Wnt signaling pathway.
GO:0051168; Biological process: nuclear export.
GO:0051255; Biological process: spindle midzone assembly.
GO:0005737; Cellular component: cytoplasm.
GO:0005813; Cellular component: centrosome.
GO:0030496; Cellular component: midbody.

Cross-references [?]

Pfam PF06818; Fez1; 1;
PROSITE PS50324; SER_RICH; 0-unlimited;
PS50312; ASP_RICH; 0-unlimited;
PS50313; GLU_RICH; 0-unlimited;
PS50318; LYS_RICH; 0-unlimited;
PS50323; ARG_RICH; 0-unlimited;

Computed features [?]

General Coiled_coil; -; 0-unlimited;

Features [?]

case <OC:Mammalia>
From: LZTS2_HUMAN (Q9BRK4)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     631     640       Nuclear export signal     L-x-x-x-L-x-x-L-x-L  
end case

Additional information [?]

Size range 666-683 amino acids
Related rules None
Fusion None


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