![]() |
|
Annotation rule MF_03026 |
Accession | MF_03026 |
Dates | 3-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 12) |
Name | LZTS2 |
Scope | Eukaryota; Vertebrata |
Templates | Q9BRK4 (LZTS2_HUMAN); Q3LUD4 (LZTS2_RAT): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Protein name |
|
Gene name |
|
Function | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
Function | Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |
Subunit | Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23. |
Subcellular location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis. |
Subcellular location | Cytoplasm. Cytoplasm, cytoskeleton, centrosome. |
Similarity | Belongs to the LZTS2 family. |
Pfam | PF06818; Fez1; 1; |
PROSITE | PS50324; SER_RICH; 0-unlimited; |
PS50312; ASP_RICH; 0-unlimited; | |
PS50313; GLU_RICH; 0-unlimited; | |
PS50318; LYS_RICH; 0-unlimited; | |
PS50323; ARG_RICH; 0-unlimited; |
General | Coiled_coil; -; 0-unlimited; |
From: LZTS2_HUMAN (Q9BRK4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOTIF | 631 | 640 | Nuclear export signal | L-x-x-x-L-x-x-L-x-L |
Size range | 666-683 amino acids |
Related rules | None |
Fusion | None |