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HAMAP rule MF_03027

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General rule information [?]

Accession MF_03027
Dates 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name BOP1
Scope(s) Eukaryota
Template(s) Q14137 (BOP1_HUMAN); P97452 (BOP1_MOUSE); Q04660 (ERB1_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03027 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier ERB1
else
Identifier BOP1
end case
case <OC:Vertebrata>
Protein name RecName: Full=Ribosome biogenesis protein @gn(BOP1);
AltName: Full=Block of proliferation 1 protein;
else case <OC:Fungi>
Protein name RecName: Full=Ribosome biogenesis protein @gn(ERB1);
AltName: Full=Eukaryotic ribosome biogenesis protein 1;
else
Protein name RecName: Full=Ribosome biogenesis protein BOP1 homolog;
end case
case <OC:Vertebrata>
Gene name Name=BOP1;
else case <OC:Fungi>
Gene name Name=ERB1;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONComponent of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
FUNCTIONComponent of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
FUNCTIONRequired for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Mammalia>
SUBUNITComponent of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Vertebrata>
SUBUNITComponent of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
SUBUNITComponent of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
SUBCELLULAR LOCATIONNucleus, nucleolus. Nucleus, nucleoplasm.
SIMILARITYBelongs to the WD repeat BOP1/ERB1 family.

Keywords [?]


Gene Ontology [?]

GO:0043021; Molecular function:ribonucleoprotein complex binding
GO:0000463; Biological process:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466; Biological process:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042273; Biological process:ribosomal large subunit biogenesis
GO:0005634; Cellular component:nucleus
GO:0005730; Cellular component:nucleolus
GO:0030687; Cellular component:preribosome, large subunit precursor

Cross-references [?]

PROSITE PS00678; WD_REPEATS_1; 1;
PROSITE PS50082; WD_REPEATS_2; 2;
PROSITE PS50294; WD_REPEATS_REGION; 2;
Pfam PF08145; BOP1NT; 1;
Pfam PF00400; WD40; 4;
REP Repeat_WD40; WD40; 6-7;

Features [?]


Additional information [?]

Size range 605-1032 amino acids
Related rules None
Fusion Nter: None Cter: None



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