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HAMAP rule MF_03028

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General rule information [?]

Accession MF_03028
Dates 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name Pescadillo
Scope
Eukaryota
Templates O00541 (PESC_HUMAN); Q9EQ61 (PESC_MOUSE); P79741 (PESC_DANRE); Q95Y89 (PESC_CAEEL); Q9VL96 (PESC_DROME); P53261 (PESC_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PESC
case <OC:Caenorhabditis>
Protein name
RecName: Full=Pescadillo homolog;
AltName: Full=Lipid depleted protein 7;
else case <OC:Fungi>
Protein name
RecName: Full=Pescadillo homolog;
AltName: Full=Nucleolar protein 7 homolog;
else
Protein name
RecName: Full=Pescadillo homolog;
end case
case <OC:Vertebrata>
Gene name
PES1
else case <OC:Caenorhabditis>
Gene name
lpd-7
else case <OC:Fungi>
Gene name
NOP7
end case

Comments [?]

case <OC:Vertebrata>
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
Function Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
Function Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Mammalia>
Subunit Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.
else case <OC:Vertebrata>
Subunit Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
Subunit Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
case <OC:Mammalia>
Subcellular location Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli.
else
Subcellular location Nucleus, nucleolus. Nucleus, nucleoplasm.
end case
case <OC:Mammalia>
Ptm Sumoylated.
end case
Similarity Belongs to the pescadillo family.

Keywords [?]

Nucleus
Ribosome biogenesis
rRNA processing
case <OC:Mammalia>
Chromosome
Ubl conjugation
end case

Gene Ontology [?]

GO:0043021; Molecular function: ribonucleoprotein complex binding.
GO:0000463; Biological process: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0000466; Biological process: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0005634; Cellular component: nucleus.
GO:0005730; Cellular component: nucleolus.
GO:0030687; Cellular component: preribosome, large subunit precursor.

Cross-references [?]

PROSITE PS50172; BRCT; 1; trigger=PRU00033;
Pfam PF00533; BRCT; 1;
PF06732; Pescadillo_N; 1;
PROSITE PS50312; ASP_RICH; 0-unlimited;
PS50313; GLU_RICH; 0-unlimited;
PS50318; LYS_RICH; 0-unlimited;
PS50323; ARG_RICH; 0-unlimited;

Computed features [?]

General Coiled_coil; -; 0-unlimited;

Additional information [?]

Size range 451-725 amino acids
Related rules None
Fusion None


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