HAMAP rule MF_03029
General rule information
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Accession | MF_03029 |
Dates | 12-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 9) |
Name | WDR12 |
Scope | Eukaryota |
Templates | Q9GZL7 (WDR12_HUMAN); Q12024 (YTM1_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Fungi>
Identifier |
|
else
Identifier |
|
end case
case <OC:Vertebrata>
Protein name |
|
else case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Caenorhabditis>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
else case <OC:Fungi>
Function | Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
else
Function | Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. |
end case
case <OC:Vertebrata>
Subunit | Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome. |
else case <OC:Fungi>
Subunit | Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome. |
end case
Subcellular location | Nucleus, nucleolus. Nucleus, nucleoplasm. |
Similarity | Belongs to the WD repeat WDR12/YTM1 family. |
Keywords
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Gene Ontology
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GO:0043021; Molecular function: ribonucleoprotein complex binding.
GO:0000463; Biological process: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0000466; Biological process: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0005634; Cellular component: nucleus.
GO:0005730; Cellular component: nucleolus.
GO:0030687; Cellular component: preribosome, large subunit precursor.
GO:0000463; Biological process: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0000466; Biological process: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0005634; Cellular component: nucleus.
GO:0005730; Cellular component: nucleolus.
GO:0030687; Cellular component: preribosome, large subunit precursor.
Cross-references
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PROSITE | PS00678; WD_REPEATS_1; 2; |
PS50082; WD_REPEATS_2; 5; | |
PS50294; WD_REPEATS_REGION; 1; | |
Pfam | PF08154; NLE; 1; |
PF00400; WD40; 7; |
Computed features
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REP | Repeat_WD40; WD40; 6-7; trigger=yes; |
Additional information
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Size range | 416-528 amino acids |
Related rules | None |
Fusion | None |