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HAMAP rule MF_03029

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General rule information [?]

Accession MF_03029
Dates 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name WDR12
Scope(s) Eukaryota
Template(s) Q9GZL7 (WDR12_HUMAN); Q12024 (YTM1_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03029 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier YTM1
else
Identifier WDR12
end case
case <OC:Vertebrata>
Protein name RecName: Full=Ribosome biogenesis protein @gn(WDR12);
AltName: Full=WD repeat-containing protein 12;
else case <OC:Fungi>
Protein name RecName: Full=Ribosome biogenesis protein @gn(YTM1);
else
Protein name RecName: Full=Ribosome biogenesis protein WDR12 homolog;
end case
case <OC:Vertebrata>
Gene name Name=WDR12;
else case <OC:Caenorhabditis>
Gene name Name=wdr-12;
else case <OC:Fungi>
Gene name Name=YTM1;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONComponent of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
FUNCTIONComponent of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
FUNCTIONRequired for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Vertebrata>
SUBUNITComponent of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
SUBUNITComponent of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
SUBCELLULAR LOCATIONNucleus, nucleolus. Nucleus, nucleoplasm.
SIMILARITYBelongs to the WD repeat WDR12/YTM1 family.

Keywords [?]


Gene Ontology [?]

GO:0043021; Molecular function:ribonucleoprotein complex binding
GO:0000463; Biological process:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466; Biological process:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042273; Biological process:ribosomal large subunit biogenesis
GO:0005634; Cellular component:nucleus
GO:0005730; Cellular component:nucleolus
GO:0030687; Cellular component:preribosome, large subunit precursor

Cross-references [?]

PROSITE PS00678; WD_REPEATS_1; 2;
PROSITE PS50082; WD_REPEATS_2; 5;
PROSITE PS50294; WD_REPEATS_REGION; 1;
Pfam PF08154; NLE; 1;
Pfam PF00400; WD40; 7;
REP Repeat_WD40; WD40; 6-7;

Features [?]


Additional information [?]

Size range 416-528 amino acids
Related rules None
Fusion Nter: None Cter: None



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