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Annotation rule MF_03029 |
General rule information
[?]
Accession |
MF_03029 |
Dates |
12-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 9) |
Propagated annotation
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Identifier, protein and gene names
[?]
case <OC:Fungi>
else
end case
case <OC:Vertebrata>
Protein name |
RecName:
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Full=Ribosome biogenesis protein @gn(WDR12);
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AltName:
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Full=WD repeat-containing protein 12;
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|
else case <OC:Fungi>
Protein name |
RecName:
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Full=Ribosome biogenesis protein @gn(YTM1);
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|
else
Protein name |
RecName:
|
Full=Ribosome biogenesis protein WDR12 homolog;
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|
end case
case <OC:Vertebrata>
else case <OC:Caenorhabditis>
else case <OC:Fungi>
end case
case <OC:Vertebrata>
Function |
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
else case <OC:Fungi>
Function |
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
else
Function |
Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. |
end case
case <OC:Vertebrata>
Subunit |
Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome. |
else case <OC:Fungi>
Subunit |
Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome. |
end case
Subcellular location |
Nucleus, nucleolus. Nucleus, nucleoplasm. |
Similarity |
Belongs to the WD repeat WDR12/YTM1 family. |
GO:0043021; Molecular function: ribonucleoprotein complex binding.
GO:0000463; Biological process: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0000466; Biological process: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0005634; Cellular component: nucleus.
GO:0005730; Cellular component: nucleolus.
GO:0030687; Cellular component: preribosome, large subunit precursor.
REP |
Repeat_WD40; WD40; 6-7; trigger=yes; |
Additional information
[?]
Size range |
416-528 amino acids |
Related rules |
None |
Fusion |
None |