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HAMAP rule MF_03029

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General rule information [?]

Accession MF_03029
Dates 12-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name WDR12
Scope
Eukaryota
Templates Q9GZL7 (WDR12_HUMAN); Q12024 (YTM1_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Fungi>
Identifier
YTM1
else
Identifier
WDR12
end case
case <OC:Vertebrata>
Protein name
RecName: Full=Ribosome biogenesis protein @gn(WDR12);
AltName: Full=WD repeat-containing protein 12;
else case <OC:Fungi>
Protein name
RecName: Full=Ribosome biogenesis protein @gn(YTM1);
else
Protein name
RecName: Full=Ribosome biogenesis protein WDR12 homolog;
end case
case <OC:Vertebrata>
Gene name
WDR12
else case <OC:Caenorhabditis>
Gene name
wdr-12
else case <OC:Fungi>
Gene name
YTM1
end case

Comments [?]

case <OC:Vertebrata>
Function Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else case <OC:Fungi>
Function Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
else
Function Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.
end case
case <OC:Vertebrata>
Subunit Component of the PeBoW complex, composed of @gn(BOP1), @gn(PES1) and @gn(WDR12). Within the PeBoW complex @gn(BOP1) interacts directly with @gn(PES1) and @gn(WDR12). The PeBoW complex also associates with the 66S pre-ribosome.
else case <OC:Fungi>
Subunit Component of the NOP7 complex, composed of @gn(ERB1), @gn(NOP7) and @gn(YTM1). Within the NOP7 complex @gn(ERB1) appears to interact directly with @gn(NOP7) and @gn(YTM1). The NOP7 complex also associates with the 66S pre-ribosome.
end case
Subcellular location Nucleus, nucleolus. Nucleus, nucleoplasm.
Similarity Belongs to the WD repeat WDR12/YTM1 family.

Keywords [?]

Nucleus
Ribosome biogenesis
rRNA processing

Gene Ontology [?]

GO:0043021; Molecular function: ribonucleoprotein complex binding.
GO:0000463; Biological process: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0000466; Biological process: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA).
GO:0042273; Biological process: ribosomal large subunit biogenesis.
GO:0005634; Cellular component: nucleus.
GO:0005730; Cellular component: nucleolus.
GO:0030687; Cellular component: preribosome, large subunit precursor.

Cross-references [?]

PROSITE PS00678; WD_REPEATS_1; 2;
PS50082; WD_REPEATS_2; 5;
PS50294; WD_REPEATS_REGION; 1;
Pfam PF08154; NLE; 1;
PF00400; WD40; 7;

Computed features [?]

REP Repeat_WD40; WD40; 6-7; trigger=yes;

Additional information [?]

Size range 416-528 amino acids
Related rules None
Fusion None


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