Home  |  Contact
Annotation rule MF_03030
Send feedback

General rule information [?]

Accession MF_03030
Dates 17-JAN-2013 (Created)
20-NOV-2019 (Last updated, Version 9)
Name MGME1
Scope
Eukaryota; Metazoa
Template Q9BQP7 (MGME1_HUMAN)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MGME1
Protein name
RecName: Full=Mitochondrial genome maintenance exonuclease 1;
EC 3.1.-.-;
case <OC:Vertebrata>
Gene name
MGME1
end case

Comments [?]

case <OC:Mammalia>
Function Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
else case <OC:Vertebrata>
Function Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair.
else
Function Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance.
end case
Subcellular location Mitochondrion.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the MGME1 family.

Keywords [?]


Gene Ontology [?]

GO:0005739; Cellular component: mitochondrion.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0043504; Biological process: mitochondrial DNA repair.
GO:0008297; Molecular function: single-stranded DNA exodeoxyribonuclease activity.

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: MGME1_HUMAN (Q9BQP7)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     238     238             D  
ACT_SITE     251     251             [DE]  
ACT_SITE     253     253             K  

Additional information [?]

Size range 182-455 amino acids
Related rules None
Fusion None