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Annotation rule MF_03034
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General rule information [?]

Accession MF_03034
Dates 15-APR-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name TRBP2
Scope
Eukaryota; Vertebrata
Templates Q15633 (TRBP2_HUMAN); P97473 (TRBP2_MOUSE): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRBP2
Protein name
RecName: Full=RISC-loading complex subunit @gn(TARBP2);
Gene name
TARBP2

Comments [?]

Function Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Within the RLC/miRLC, @gn(DICER1) and @gn(TARBP2) are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto @gn(AGO2). @gn(AGO2) bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from @gn(DICER1) and @gn(TARBP2). May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by @gn(DICER1).
case <OC:Mammalia>
Subunit Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
else
Subunit Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Note that the trimeric RLC/miRLC is also referred to as RISC.
end case
case <OC:Mammalia>
Subcellular location Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
else
Subcellular location Cytoplasm.
end case
Similarity Belongs to the TARBP2 family.

Keywords [?]

case <OC:Mammalia>
end case

Gene Ontology [?]

GO:0035197; Molecular function: siRNA binding.
GO:0035198; Molecular function: miRNA binding.
GO:0042803; Molecular function: protein homodimerization activity.
GO:0030422; Biological process: production of siRNA involved in RNA interference.
GO:0030423; Biological process: targeting of mRNA for destruction involved in RNA interference.
GO:0031054; Biological process: pre-miRNA processing.
GO:0035280; Biological process: miRNA loading onto RISC involved in gene silencing by miRNA.
GO:0016442; Cellular component: RISC complex.

Cross-references [?]

PROSITE PS50137; DS_RBD; 3; trigger=PRU00266;
Pfam PF00035; dsrm; 2;

Features [?]

case <OC:Mammalia>
From: TRBP2_HUMAN (Q15633)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     22     105       Sufficient for interaction with PRKRA        
REGION     152     234       Sufficient for interaction with PRKRA        
REGION     228     366       Sufficient for interaction with DICER1        
REGION     287     366       Sufficient for interaction with PRKRA        
end case

Additional information [?]

Size range 319-366 amino acids
Related rules None
Fusion None