HAMAP rule MF_03034
General rule information
[?]
| Accession | MF_03034 |
| Dates | 15-APR-2009 (Created) 3-MAY-2022 (Last updated, Version 9) |
| Name | TRBP2 |
| Scope | Eukaryota; Vertebrata |
| Templates | Q15633 (TRBP2_HUMAN); P97473 (TRBP2_MOUSE): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
| Protein name |
|
||||
| Gene name |
|
Comments
[?]
| Function | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Within the RLC/miRLC, @gn(DICER1) and @gn(TARBP2) are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto @gn(AGO2). @gn(AGO2) bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from @gn(DICER1) and @gn(TARBP2). May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by @gn(DICER1). |
case <OC:Mammalia>
| Subunit | Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). |
else
| Subunit | Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of @gn(DICER1), @gn(AGO2) and @gn(TARBP2). Note that the trimeric RLC/miRLC is also referred to as RISC. |
end case
case <OC:Mammalia>
| Subcellular location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. |
else
| Subcellular location | Cytoplasm. |
end case
| Similarity | Belongs to the TARBP2 family. |
Keywords
[?]
case <OC:Mammalia>
end case
Gene Ontology
[?]
GO:0035197; Molecular function: siRNA binding.
GO:0035198; Molecular function: miRNA binding.
GO:0042803; Molecular function: protein homodimerization activity.
GO:0030422; Biological process: siRNA processing.
GO:0098795; Biological process: global gene silencing by mRNA cleavage.
GO:0031054; Biological process: pre-miRNA processing.
GO:0070922; Biological process: RISC complex assembly.
GO:0016442; Cellular component: RISC complex.
GO:0035198; Molecular function: miRNA binding.
GO:0042803; Molecular function: protein homodimerization activity.
GO:0030422; Biological process: siRNA processing.
GO:0098795; Biological process: global gene silencing by mRNA cleavage.
GO:0031054; Biological process: pre-miRNA processing.
GO:0070922; Biological process: RISC complex assembly.
GO:0016442; Cellular component: RISC complex.
Cross-references
[?]
Features
[?]
case <OC:Mammalia>
| From: TRBP2_HUMAN (Q15633) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| REGION | 22 | 105 | Sufficient for interaction with PRKRA | |||||||||
| REGION | 152 | 234 | Sufficient for interaction with PRKRA | |||||||||
| REGION | 228 | 366 | Sufficient for interaction with DICER1 | |||||||||
| REGION | 287 | 366 | Sufficient for interaction with PRKRA | |||||||||
end case
Additional information
[?]
| Size range | 319-366 amino acids |
| Related rules | None |
| Fusion | None |