HAMAP rule MF_03036
General rule information
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Accession | MF_03036 |
Dates | 2-JUN-2009 (Created)
14-MAY-2022 (Last updated, Version 14) |
Name | Nuc_phosphate_hydrolase |
Scope(s) |
Bacteria Eukaryota Archaea |
Template(s) | O35820 (DNPH1_RAT); O43598 (DNPH1_HUMAN); [ Recover all ] |
Triggered by |
HAMAP; MF_03036 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | DNPH1 |
case <OC:Mammalia> | |
Protein name | RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; AltName: Full=c-Myc-responsive protein @gn(RCL); |
else case <OC:Vertebrata> | |
Protein name | RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; |
else | |
Protein name | RecName: Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; |
end case | |
case <OC:Mammalia> | |
Gene name | Name=DNPH1; Synonyms=RCL; |
else case <OC:Vertebrata> | |
Gene name | Name=DNPH1; |
end case |
Comments
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case <OC:Vertebrata> | |
FUNCTION | Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. |
else | |
FUNCTION | Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. |
end case | |
CATALYTIC ACTIVITY | Reaction=a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2- deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase; Xref=Rhea:RHEA:57852, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432, ChEBI:CHEBI:62877, ChEBI:CHEBI:142209; |
CATALYTIC ACTIVITY | Reaction=a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy- D-ribose 5-phosphate + a purine nucleobase; Xref=Rhea:RHEA:51132, ChEBI:CHEBI:15377, ChEBI:CHEBI:26386, ChEBI:CHEBI:62877, ChEBI:CHEBI:142198; |
SUBUNIT | Monomer and homodimer. |
case <OC:Eukaryota> | |
SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
end case | |
SIMILARITY | Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. |
Keywords
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case <OC:Eukaryota> | |
Cytoplasm | |
Nucleus | |
end case | |
Glycosidase | |
Hydrolase | |
Nucleotide metabolism |
Gene Ontology
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GO:0016799; Molecular function:hydrolase activity, hydrolyzing N-glycosyl compounds | |
GO:0009116; Biological process:nucleoside metabolic process | |
case <OCellular component:Mammalia> | |
GO:0042803; Molecular function:protein homodimerization activity | |
end case | |
case <OCellular component:Eukaryota> | |
GO:0005634; Cellular component:nucleus | |
GO:0005737; Cellular component:cytoplasm | |
end case |
Cross-references
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Pfam | PF05014; Nuc_deoxyrib_tr; 1; |
Features
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From: DNPH1_RAT (O35820) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Mammalia> | ||||||||||||
INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
end case | ||||||||||||
BINDING | 13 | 19 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
[YF]-x-[CS]-G-S-[IM]-R | ||||||||
BINDING | 117 | 119 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" |
S-[ASG]-[ML] | ||||||||
BINDING | 28 | 28 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
Y | ||||||||
BINDING | 93 | 93 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
E |
Additional information
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Size range | 105-174 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |