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HAMAP rule MF_03036

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General rule information [?]

Accession MF_03036
Dates 2-JUN-2009 (Created)
14-MAY-2022 (Last updated, Version 14)
Name Nuc_phosphate_hydrolase
Scope(s) Bacteria
Eukaryota
Archaea
Template(s) O35820 (DNPH1_RAT); O43598 (DNPH1_HUMAN); [ Recover all ]
Triggered by HAMAP; MF_03036 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DNPH1
case <OC:Mammalia>
Protein name RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
                 EC=3.2.2.-;
AltName: Full=c-Myc-responsive protein @gn(RCL);
else case <OC:Vertebrata>
Protein name RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
                 EC=3.2.2.-;
else
Protein name RecName: Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
                 EC=3.2.2.-;
end case
case <OC:Mammalia>
Gene name Name=DNPH1; Synonyms=RCL;
else case <OC:Vertebrata>
Gene name Name=DNPH1;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONCatalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
else
FUNCTIONCatalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
end case
CATALYTIC ACTIVITY Reaction=a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2- deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase; Xref=Rhea:RHEA:57852, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432, ChEBI:CHEBI:62877, ChEBI:CHEBI:142209;
CATALYTIC ACTIVITY Reaction=a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy- D-ribose 5-phosphate + a purine nucleobase; Xref=Rhea:RHEA:51132, ChEBI:CHEBI:15377, ChEBI:CHEBI:26386, ChEBI:CHEBI:62877, ChEBI:CHEBI:142198;
SUBUNITMonomer and homodimer.
case <OC:Eukaryota>
SUBCELLULAR LOCATIONCytoplasm. Nucleus.
end case
SIMILARITYBelongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.

Keywords [?]


Gene Ontology [?]

GO:0016799; Molecular function:hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0009116; Biological process:nucleoside metabolic process
case <OCellular component:Mammalia>
GO:0042803; Molecular function:protein homodimerization activity
end case
case <OCellular component:Eukaryota>
GO:0005634; Cellular component:nucleus
GO:0005737; Cellular component:cytoplasm
end case

Cross-references [?]

Pfam PF05014; Nuc_deoxyrib_tr; 1;

Features [?]

From: DNPH1_RAT (O35820)
Key From To Description Tag Condition FTGroup
case <OC:Mammalia>
INIT_MET 1 1 /note="Removed" M
end case
BINDING 13 19 /ligand="substrate"
/ligand_note="ligand shared between homodimeric partners"
/note="in other chain"
[YF]-x-[CS]-G-S-[IM]-R
BINDING 117 119 /ligand="substrate"
/ligand_note="ligand shared between homodimeric partners"
S-[ASG]-[ML]
BINDING 28 28 /ligand="substrate"
/ligand_note="ligand shared between homodimeric partners"
/note="in other chain"
Y
BINDING 93 93 /ligand="substrate"
/ligand_note="ligand shared between homodimeric partners"
/note="in other chain"
E

Additional information [?]

Size range 105-174 amino acids
Related rules None
Fusion Nter: None Cter: None



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