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HAMAP rule MF_03036

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General rule information [?]

Accession MF_03036
Dates 2-JUN-2009 (Created)
14-MAY-2022 (Last updated, Version 14)
Name Nuc_phosphate_hydrolase
Scope
Bacteria
Eukaryota
Archaea
Templates O35820 (DNPH1_RAT); O43598 (DNPH1_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DNPH1
case <OC:Mammalia>
Protein name
RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
EC 3.2.2.-;
AltName: Full=c-Myc-responsive protein @gn(RCL);
else case <OC:Vertebrata>
Protein name
RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
EC 3.2.2.-;
else
Protein name
RecName: Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
EC 3.2.2.-;
end case
case <OC:Mammalia>
Gene name
DNPH1, RCL
else case <OC:Vertebrata>
Gene name
DNPH1
end case

Comments [?]

case <OC:Vertebrata>
Function Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
else
Function Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base.
end case
Catalytic activity RHEA:57852: a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase
RHEA:51132: a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase
Subunit Monomer and homodimer.
case <OC:Eukaryota>
Subcellular location Cytoplasm. Nucleus.
end case
Similarity Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.

Keywords [?]

case <OC:Eukaryota>
Cytoplasm
Nucleus
end case
Glycosidase
Hydrolase
Nucleotide metabolism

Gene Ontology [?]

GO:0016799; Molecular function: hydrolase activity, hydrolyzing N-glycosyl compounds.
GO:0009116; Biological process: nucleoside metabolic process.
case <OC:Mammalia>
GO:0042803; Molecular function: protein homodimerization activity.
end case
case <OC:Eukaryota>
GO:0005634; Cellular component: nucleus.
GO:0005737; Cellular component: cytoplasm.
end case

Cross-references [?]

Pfam PF05014; Nuc_deoxyrib_tr; 1;

Features [?]

case <OC:Mammalia>
From: DNPH1_RAT (O35820)
Key     From     To       Description   Tag   Condition   FTGroup
INIT_MET     1     1       Removed     M  
end case
BINDING     13     19       /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain     [YF]-x-[CS]-G-S-[IM]-R  
BINDING     117     119       /ligand="substrate" /ligand_note="ligand shared between homodimeric partners     S-[ASG]-[ML]  
BINDING     28     28       /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain     Y  
BINDING     93     93       /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain     E  

Additional information [?]

Size range 105-174 amino acids
Related rules None
Fusion None


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