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Annotation rule MF_03036 |
General rule information
[?]
Accession |
MF_03036 |
Dates |
2-JUN-2009 (Created) 14-MAY-2022 (Last updated, Version 14) |
Name |
Nuc_phosphate_hydrolase |
Scope |
Bacteria
Eukaryota
Archaea |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
Protein name |
RecName:
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Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
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EC 3.2.2.-;
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AltName:
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Full=c-Myc-responsive protein @gn(RCL);
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else case <OC:Vertebrata>
Protein name |
RecName:
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Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
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EC 3.2.2.-;
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else
Protein name |
RecName:
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Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1;
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EC 3.2.2.-;
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end case
case <OC:Mammalia>
else case <OC:Vertebrata>
end case
case <OC:Vertebrata>
Function |
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. |
else
Function |
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. |
end case
Catalytic activity |
RHEA:57852: a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase
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RHEA:51132: a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase
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Subunit |
Monomer and homodimer. |
case <OC:Eukaryota>
Subcellular location |
Cytoplasm. Nucleus. |
end case
Similarity |
Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. |
case <OC:Eukaryota>
end case
GO:0016799; Molecular function: hydrolase activity, hydrolyzing N-glycosyl compounds.
GO:0009116; Biological process: nucleoside metabolic process.
case <OC:Mammalia>
GO:0042803; Molecular function: protein homodimerization activity.
end case
case <OC:Eukaryota>
end case
case <OC:Mammalia>
From: DNPH1_RAT (O35820) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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INIT_MET
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1
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1
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Removed
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M
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end case
BINDING
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13
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19
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/ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain
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[YF]-x-[CS]-G-S-[IM]-R
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BINDING
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117
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119
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/ligand="substrate" /ligand_note="ligand shared between homodimeric partners
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S-[ASG]-[ML]
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BINDING
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28
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28
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/ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain
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Y
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BINDING
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93
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93
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/ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain
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E
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Additional information
[?]
Size range |
105-174 amino acids |
Related rules |
None |
Fusion |
None |