HAMAP rule MF_03036
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_03036 |
| Accession | MF_03036 |
| Dates | 02-JUN-2009 (Created)
02-SEP-2024 (Last updated, Version 16) |
| Name | Nuc_phosphate_hydrolase |
| Scope(s) |
Bacteria Eukaryota Archaea |
| Template(s) | O35820; O43598; [ Recover all ] |
| Triggered by |
HAMAP; MF_03036 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DNPH1 |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; AltName: Full=c-Myc-responsive protein @gn(RCL); |
| else case <OC:Vertebrata> | |
| Protein name | RecName: Full=2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; |
| else | |
| Protein name | RecName: Full=Putative 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; EC=3.2.2.-; |
| end case | |
| case <OC:Mammalia> | |
| Gene name | Name=DNPH1; Synonyms=RCL; |
| else case <OC:Vertebrata> | |
| Gene name | Name=DNPH1; |
| end case | |
Comments
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| case <OC:Vertebrata> | |
| FUNCTION | Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. |
| else | |
| FUNCTION | Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + 2-deoxy-D-ribose 5-phosphate; Xref=Rhea:RHEA:57852, ChEBI:CHEBI:15377, ChEBI:CHEBI:26432, ChEBI:CHEBI:62877, ChEBI:CHEBI:142209; |
| CATALYTIC ACTIVITY | Reaction=a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = a purine nucleobase + 2-deoxy-D-ribose 5-phosphate; Xref=Rhea:RHEA:51132, ChEBI:CHEBI:15377, ChEBI:CHEBI:26386, ChEBI:CHEBI:62877, ChEBI:CHEBI:142198; |
| SUBUNIT | Monomer and homodimer. |
| case <OC:Eukaryota> | |
| SUBCELLULAR LOCATION | Cytoplasm. Nucleus. |
| end case | |
| SIMILARITY | Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family. |
Keywords
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| case <OC:Eukaryota> | |
| Cytoplasm | |
| Nucleus | |
| end case | |
| Glycosidase | |
| Hydrolase | |
| Nucleotide metabolism | |
Gene Ontology
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| GO:0016799; Molecular function:hydrolase activity, hydrolyzing N-glycosyl compounds | |
| GO:0009116; Biological process:nucleoside metabolic process | |
| case <OCellular component:Mammalia> | |
| GO:0042803; Molecular function:protein homodimerization activity | |
| end case | |
| case <OCellular component:Eukaryota> | |
| GO:0005634; Cellular component:nucleus | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
Cross-references
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| Pfam | PF05014; Nuc_deoxyrib_tr; 1; |
Features
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| From: DNPH1_RAT (O35820) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Mammalia> | ||||||||||||
| INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
| end case | ||||||||||||
| BINDING | 13 | 19 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
[YF]-x-[CS]-G-S-[IM]-R | ||||||||
| BINDING | 117 | 119 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" |
S-[ASG]-[ML] | ||||||||
| BINDING | 28 | 28 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
Y | ||||||||
| BINDING | 93 | 93 | /ligand="substrate" /ligand_note="ligand shared between homodimeric partners" /note="in other chain" |
E | ||||||||
Additional information
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| Size range | 105-174 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |