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Annotation rule MF_03037
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General rule information [?]

Accession MF_03037
Dates 20-JUL-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name ciao1
Scope
Eukaryota
Templates O76071 (CIAO1_HUMAN); Q05583 (CIAO1_YEAST): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CIAO1
case <OC:Mammalia>
Protein name
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1;
AltName: Full=WD repeat-containing protein 39;
else case <OC:Vertebrata>
Protein name
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein @gn(CIAO1);
AltName: Full=WD repeat-containing protein 39;
else case <OC:Arthropoda>
Protein name
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1;
else case <OC:Fungi>
Protein name
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1;
else
Protein name
RecName: Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog;
end case
case <OC:Vertebrata>
Gene name
CIAO1
else case <OC:Arthropoda>
Gene name
Ciao1
else case <OC:Fungi>
Gene name
CIA1
end case

Comments [?]

case <OC:Mammalia>
Function Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
else case <OC:Vertebrata>
Function Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins.
else
Function Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.
end case
case <OC:Mammalia>
Subunit Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
else case <OC:Vertebrata>
Subunit Component of the CIA complex.
else case <OC:Saccharomycetes>
Subunit Interacts with @gn(NAR1).
end case
case <OC:Saccharomycetes>
Subcellular location Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus.
end case
Similarity Belongs to the WD repeat CIA1 family.

Keywords [?]

case <OC:Mammalia>
end case
case <OC:Saccharomycetes>
end case

Gene Ontology [?]

case <OC:Mammalia>
GO:0097361; Cellular component: CIA complex.
GO:0071817; Cellular component: MMXD complex.
end case
GO:0016226; Biological process: iron-sulfur cluster assembly.

Cross-references [?]

PROSITE PS00678; WD_REPEATS_1; 1;
PS50082; WD_REPEATS_2; 7;
PS50294; WD_REPEATS_REGION; 1;
Pfam PF00400; WD40; 7;

Computed features [?]

REP Repeat_WD40; WD40; 7; trigger=yes;

Additional information [?]

Size range 313-506 amino acids
Related rules None
Fusion Nter: MF_03039; Cter: None