 |
|
Annotation rule MF_03037 |
General rule information
[?]
Accession |
MF_03037 |
Dates |
20-JUL-2009 (Created) 20-NOV-2019 (Last updated, Version 6) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
Protein name |
RecName:
|
Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1;
|
AltName:
|
Full=WD repeat-containing protein 39;
|
|
else case <OC:Vertebrata>
Protein name |
RecName:
|
Full=Probable cytosolic iron-sulfur protein assembly protein @gn(CIAO1);
|
AltName:
|
Full=WD repeat-containing protein 39;
|
|
else case <OC:Arthropoda>
Protein name |
RecName:
|
Full=Probable cytosolic iron-sulfur protein assembly protein Ciao1;
|
|
else case <OC:Fungi>
Protein name |
RecName:
|
Full=Probable cytosolic iron-sulfur protein assembly protein 1;
|
|
else
Protein name |
RecName:
|
Full=Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog;
|
|
end case
case <OC:Vertebrata>
else case <OC:Arthropoda>
else case <OC:Fungi>
end case
case <OC:Mammalia>
Function |
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
else case <OC:Vertebrata>
Function |
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. |
else
Function |
Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. |
end case
case <OC:Mammalia>
Subunit |
Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A. |
else case <OC:Vertebrata>
Subunit |
Component of the CIA complex. |
else case <OC:Saccharomycetes>
Subunit |
Interacts with @gn(NAR1). |
end case
case <OC:Saccharomycetes>
Subcellular location |
Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus. |
end case
Similarity |
Belongs to the WD repeat CIA1 family. |
case <OC:Mammalia>
end case
case <OC:Saccharomycetes>
end case
case <OC:Mammalia>
end case
GO:0016226; Biological process: iron-sulfur cluster assembly.
REP |
Repeat_WD40; WD40; 7; trigger=yes; |
Additional information
[?]
Size range |
313-506 amino acids |
Related rules |
None |
Fusion |
Nter: MF_03039; Cter: None |