HAMAP rule MF_03037
General rule information
[?]
Accession | MF_03037 |
Dates | 20-JUL-2009 (Created) 20-NOV-2019 (Last updated, Version 6) |
Name | ciao1 |
Scope | Eukaryota |
Templates | O76071 (CIAO1_HUMAN); Q05583 (CIAO1_YEAST): [Recover all] |
Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier |
|
case <OC:Mammalia>
Protein name |
|
else case <OC:Vertebrata>
Protein name |
|
else case <OC:Arthropoda>
Protein name |
|
else case <OC:Fungi>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Arthropoda>
Gene name |
|
else case <OC:Fungi>
Gene name |
|
end case
Comments
[?]
case <OC:Mammalia>
Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. |
else case <OC:Vertebrata>
Function | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. |
else
Function | Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. |
end case
case <OC:Mammalia>
Subunit | Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A. |
else case <OC:Vertebrata>
Subunit | Component of the CIA complex. |
else case <OC:Saccharomycetes>
Subunit | Interacts with @gn(NAR1). |
end case
case <OC:Saccharomycetes>
Subcellular location | Cytoplasm. Nucleus. Note=Preferentially localized to the nucleus. |
end case
Similarity | Belongs to the WD repeat CIA1 family. |
Keywords
[?]
case <OC:Mammalia>
end case
case <OC:Saccharomycetes>
end case
Gene Ontology
[?]
case <OC:Mammalia>
end case
GO:0016226; Biological process: iron-sulfur cluster assembly.
Cross-references
[?]
PROSITE | PS00678; WD_REPEATS_1; 1; |
PS50082; WD_REPEATS_2; 7; | |
PS50294; WD_REPEATS_REGION; 1; | |
Pfam | PF00400; WD40; 7; |
Computed features
[?]
REP | Repeat_WD40; WD40; 7; trigger=yes; |
Additional information
[?]
Size range | 313-506 amino acids |
Related rules | None |
Fusion | Nter: MF_03039; Cter: None |