HAMAP rule MF_03040

General rule information [?]

Accession	MF_03040
Dates	25-OCT-2012 (Created) 7-FEB-2023 (Last updated, Version 8)
Name	USB1
Scope(s)	Eukaryota
Template(s)	Q12208 (USB1_YEAST); Q9BQ65 (USB1_HUMAN); [ Recover all ]
Triggered by	HAMAP; MF_03040 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	USB1
Protein name	RecName: Full=U6 snRNA phosphodiesterase; EC=3.1.4.-;
case <OC:Vertebrata> or <OC:Fungi>
Gene name	Name=USB1;
end case

Comments [?]

case <OC:Mammalia>
FUNCTION	Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.
else
FUNCTION	Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
end case
SUBCELLULAR LOCATION	Nucleus.
SIMILARITY	Belongs to the 2H phosphoesterase superfamily. USB1 family.

Keywords [?]

Gene Ontology [?]

GO:0005634; Cellular component:nucleus

GO:0000175; Molecular function:3'-5'-RNA exonuclease activity

GO:1990838; Molecular function:poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends

GO:0034477; Biological process:U6 snRNA 3'-end processing

Cross-references [?]

Pfam	PF09749; HVSL; 1;

Features [?]

From: USB1_YEAST (Q12208)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

133

/note="Proton donor/acceptor"

ACT_SITE

231

/note="Proton donor/acceptor"

Additional information [?]