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HAMAP rule MF_03040

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General rule information [?]

Accession MF_03040
Dates 25-OCT-2012 (Created)
7-FEB-2023 (Last updated, Version 8)
Name USB1
Scope
Eukaryota
Templates Q12208 (USB1_YEAST); Q9BQ65 (USB1_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
USB1
Protein name
RecName: Full=U6 snRNA phosphodiesterase;
EC 3.1.4.-;
case <OC:Vertebrata> or <OC:Fungi>
Gene name
USB1
end case

Comments [?]

case <OC:Mammalia>
Function Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate.
else
Function Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA.
end case
Subcellular location Nucleus.
Similarity Belongs to the 2H phosphoesterase superfamily. USB1 family.

Keywords [?]

Hydrolase
Nuclease
Nucleus

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.
GO:0000175; Molecular function: 3'-5'-RNA exonuclease activity.
GO:1990838; Molecular function: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends.
GO:0034477; Biological process: U6 snRNA 3'-end processing.

Cross-references [?]

Pfam PF09749; HVSL; 1;

Features [?]

From: USB1_YEAST (Q12208)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     133     133       Proton donor/acceptor     H  
ACT_SITE     231     231       Proton donor/acceptor     H  

Additional information [?]

Size range 227-372 amino acids
Related rules None
Fusion None


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