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Annotation rule MF_03054 |
General rule information
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Accession |
MF_03054 |
Dates |
26-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 5) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Cytoplasmic tRNA 2-thiolation protein 2;
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case <OC:Caenorhabditis>
Protein name |
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Full=Thiolation of uridine in tRNA protein 2;
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else case <OC:Saccharomyces>
Protein name |
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Full=Thiolation of uridine in cytoplasmic tRNA protein 2;
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Full=Needs CLA4 to survive protein 2;
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end case
case <OC:Vertebrata>
else case <OC:Caenorhabditis>
else case <OC:Saccharomyces>
else case <OC:Fungi>
end case
case <OC:Vertebrata>
Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(CTU1)/@gn(ATPBD3) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. |
else case <OC:Caenorhabditis>
Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position. |
else case <OC:Fungi>
Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. |
else
Function |
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6)/@gn(CTU1) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. |
end case
Pathway |
tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. |
case <OC:Mammalia>
Subunit |
Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. |
else case <OC:Saccharomyces>
Subunit |
Interacts with NCS6 and URM1. May act by forming a heterodimer with NCS6. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the CTU2/NCS2 family. |
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0002098; Biological process: tRNA wobble uridine modification.
GO:0032447; Biological process: protein urmylation.
GO:0034227; Biological process: tRNA thio-modification.
GO:0005737; Cellular component: cytoplasm.
Additional information
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Size range |
325-687 amino acids |
Related rules |
None |
Fusion |
None |