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Annotation rule MF_03054
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General rule information [?]

Accession MF_03054
Dates 26-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 5)
Name CTU2
Scope
Eukaryota
Templates Q2VPK5 (CTU2_HUMAN); P53923 (CTU2_YEAST); Q9UUC7 (CTU2_SCHPO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CTU2
Protein name
RecName: Full=Cytoplasmic tRNA 2-thiolation protein 2;
case <OC:Caenorhabditis>
Protein name
Full=Thiolation of uridine in tRNA protein 2;
else case <OC:Saccharomyces>
Protein name
Full=Thiolation of uridine in cytoplasmic tRNA protein 2;
Full=Needs CLA4 to survive protein 2;
end case
case <OC:Vertebrata>
Gene name
CTU2, NCS2
else case <OC:Caenorhabditis>
Gene name
tut-2
else case <OC:Saccharomyces>
Gene name
NCS2, CTU2, TUC2
else case <OC:Fungi>
Gene name
NCS2, CTU2
end case

Comments [?]

case <OC:Vertebrata>
Function Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(CTU1)/@gn(ATPBD3) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position.
else case <OC:Caenorhabditis>
Function Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.
else case <OC:Fungi>
Function Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.
else
Function Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with @gn(NCS6)/@gn(CTU1) that ligates sulfur from thiocarboxylated @gn(URM1) onto the uridine of tRNAs at wobble position.
end case
Pathway tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.
case <OC:Mammalia>
Subunit Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.
else case <OC:Saccharomyces>
Subunit Interacts with NCS6 and URM1. May act by forming a heterodimer with NCS6.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the CTU2/NCS2 family.

Keywords [?]


Gene Ontology [?]

GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0002098; Biological process: tRNA wobble uridine modification.
GO:0032447; Biological process: protein urmylation.
GO:0034227; Biological process: tRNA thio-modification.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01171; ATP_bind_3; 1;

Additional information [?]

Size range 325-687 amino acids
Related rules None
Fusion None