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HAMAP rule MF_03057

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General rule information [?]

Accession MF_03057
Dates 4-SEP-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name SDHAF2
Scope(s) Eukaryota
Template(s) Q9NX18 (SDHF2_HUMAN); Q08230 (SDHF2_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03057 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SDHF2
Protein name RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial;
                 Short=SDH assembly factor 2;
                 Short=SDHAF2;
case <OC:Vertebrata>
Gene name Name=SDHAF2; Synonyms=PGL2, SDH5;
else case <OC:Saccharomyces>
Gene name Name=SDH5;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTIONPlays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit @gn(SDHA) of the SDH catalytic dimer.
SUBUNITInteracts with @gn(SDHA) within the SDH catalytic dimer.
else
FUNCTIONPlays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
SUBUNITInteracts with the flavoprotein subunit within the SDH catalytic dimer.
end case
SUBCELLULAR LOCATIONMitochondrion matrix.
case not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
SIMILARITYBelongs to the SDHAF2 family.

Keywords [?]


Gene Ontology [?]

GO:0006121; Biological process:mitochondrial electron transport, succinate to ubiquinone
GO:0018293; Biological process:protein-FAD linkage
GO:0005759; Cellular component:mitochondrial matrix

Cross-references [?]

Pfam PF03937; DUF339; 1;
General TransitM; -; 0-1;

Features [?]


Additional information [?]

Size range 119-310 amino acids
Related rules None
Fusion Nter: None Cter: None



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