HAMAP rule MF_03057
General rule information
[?]
Accession | MF_03057 |
Dates | 4-SEP-2009 (Created)
20-NOV-2019 (Last updated, Version 6) |
Name | SDHAF2 |
Scope(s) |
Eukaryota |
Template(s) | Q9NX18 (SDHF2_HUMAN); Q08230 (SDHF2_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03057 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | SDHF2 |
Protein name | RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial; Short=SDH assembly factor 2; Short=SDHAF2; |
case <OC:Vertebrata> | |
Gene name | Name=SDHAF2; Synonyms=PGL2, SDH5; |
else case <OC:Saccharomyces> | |
Gene name | Name=SDH5; |
end case |
Comments
[?]
case <OC:Vertebrata> | |
FUNCTION | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit @gn(SDHA) of the SDH catalytic dimer. |
SUBUNIT | Interacts with @gn(SDHA) within the SDH catalytic dimer. |
else | |
FUNCTION | Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. |
SUBUNIT | Interacts with the flavoprotein subunit within the SDH catalytic dimer. |
end case | |
SUBCELLULAR LOCATION | Mitochondrion matrix. |
case not <AnyFeature:TransitM> | |
MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case | |
SIMILARITY | Belongs to the SDHAF2 family. |
Keywords
[?]
Gene Ontology
[?]
GO:0006121; Biological process:mitochondrial electron transport, succinate to ubiquinone |
GO:0018293; Biological process:protein-FAD linkage |
GO:0005759; Cellular component:mitochondrial matrix |
Cross-references
[?]
Features
[?]
Additional information
[?]
Size range | 119-310 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |