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Annotation rule MF_03057
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General rule information [?]

Accession MF_03057
Dates 4-SEP-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name SDHAF2
Scope
Eukaryota
Templates Q9NX18 (SDHF2_HUMAN); Q08230 (SDHF2_YEAST): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SDHF2
Protein name
RecName: Full=Succinate dehydrogenase assembly factor 2, mitochondrial;
Short=SDH assembly factor 2;
Short=SDHAF2;
case <OC:Vertebrata>
Gene name
SDHAF2, PGL2, SDH5
else case <OC:Saccharomyces>
Gene name
SDH5
end case

Comments [?]

case <OC:Vertebrata>
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit @gn(SDHA) of the SDH catalytic dimer.
Subunit Interacts with @gn(SDHA) within the SDH catalytic dimer.
else
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Subunit Interacts with the flavoprotein subunit within the SDH catalytic dimer.
end case
Subcellular location Mitochondrion matrix.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the SDHAF2 family.

Keywords [?]


Gene Ontology [?]

GO:0006121; Biological process: mitochondrial electron transport, succinate to ubiquinone.
GO:0018293; Biological process: protein-FAD linkage.
GO:0005759; Cellular component: mitochondrial matrix.

Cross-references [?]

Pfam PF03937; DUF339; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Additional information [?]

Size range 119-310 amino acids
Related rules None
Fusion None