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Annotation rule MF_03060
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General rule information [?]

Accession MF_03060
Dates 5-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 6)
Name Draxin
Scope
Eukaryota; Vertebrata
Templates Q6PAL1 (DRAXI_MOUSE); B6ZI38 (DRAXI_CHICK): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DRAXI
Protein name
RecName: Full=Draxin;
AltName: Full=Dorsal inhibitory axon guidance protein;
AltName: Full=Dorsal repulsive axon guidance protein;
Gene name
DRAXIN

Comments [?]

case <OC:Mammalia>
Function Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
Subunit Interacts with LRP6.
else
Function Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.
end case
Subcellular location Secreted.
Similarity Belongs to the draxin family.

Keywords [?]

Developmental protein
Secreted
case <OC:Mammalia>
Wnt signaling pathway
end case

Gene Ontology [?]

GO:0005576; Cellular component: extracellular region.
GO:0007411; Biological process: axon guidance.
GO:0021516; Biological process: dorsal spinal cord development.
GO:0021528; Biological process: commissural neuron differentiation in spinal cord.
GO:0030900; Biological process: forebrain development.
case <OC:Mammalia>
GO:0090090; Biological process: negative regulation of canonical Wnt signaling pathway.
end case

Cross-references [?]

PROSITE PS00001; ASN_GLYCOSYLATION; 0-10; trigger=PRU00498;

Computed features [?]

General Signal; -; 1; trigger=yes;

Additional information [?]

Size range 326-382 amino acids
Related rules None
Fusion None


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