HAMAP rule MF_03060

Accession	MF_03060
Dates	5-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 6)

Name

Draxin

Scope

Eukaryota; Vertebrata

Templates

Q6PAL1 (DRAXI_MOUSE); B6ZI38 (DRAXI_CHICK): [Recover all]

Triggered by

HAMAP; MF_03060 (Get profile general information and statistics)

Identifier

DRAXI

Protein name

RecName: Full=Draxin; AltName: Full=Dorsal inhibitory axon guidance protein; AltName: Full=Dorsal repulsive axon guidance protein;

Gene name

DRAXIN

Function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.

Subunit

Interacts with LRP6.

Function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.

Subcellular location	Secreted.
Similarity	Belongs to the draxin family.

Developmental protein
Secreted

Wnt signaling pathway

GO:0005576; Cellular component: extracellular region.
GO:0007411; Biological process: axon guidance.
GO:0021516; Biological process: dorsal spinal cord development.
GO:0021528; Biological process: commissural neuron differentiation in spinal cord.
GO:0030900; Biological process: forebrain development.

GO:0090090; Biological process: negative regulation of canonical Wnt signaling pathway.

PROSITE

PS00001; ASN_GLYCOSYLATION; 0-10; trigger=PRU00498;

General

Signal; -; 1; trigger=yes;

Size range	326-382 amino acids
Related rules	None
Fusion	None

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