HAMAP rule MF_03060
General rule information
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Accession | MF_03060 |
Dates | 5-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 6) |
Name | Draxin |
Scope | Eukaryota; Vertebrata |
Templates | Q6PAL1 (DRAXI_MOUSE); B6ZI38 (DRAXI_CHICK): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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case <OC:Mammalia>
Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. |
Subunit | Interacts with LRP6. |
else
Function | Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. |
end case
Subcellular location | Secreted. |
Similarity | Belongs to the draxin family. |
Keywords
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case <OC:Mammalia>
end case
Gene Ontology
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GO:0005576; Cellular component: extracellular region.
GO:0007411; Biological process: axon guidance.
GO:0021516; Biological process: dorsal spinal cord development.
GO:0021528; Biological process: commissural neuron differentiation in spinal cord.
GO:0030900; Biological process: forebrain development.
GO:0007411; Biological process: axon guidance.
GO:0021516; Biological process: dorsal spinal cord development.
GO:0021528; Biological process: commissural neuron differentiation in spinal cord.
GO:0030900; Biological process: forebrain development.
case <OC:Mammalia>
GO:0090090; Biological process: negative regulation of canonical Wnt signaling pathway.
end case
Cross-references
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Computed features
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General | Signal; -; 1; trigger=yes; |
Additional information
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Size range | 326-382 amino acids |
Related rules | None |
Fusion | None |