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Annotation rule MF_03061
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General rule information [?]

Accession MF_03061
Dates 4-SEP-2009 (Created)
20-NOV-2019 (Last updated, Version 7)
Name mEF-G_1
Scope
Eukaryota
Templates Q96RP9 (EFGM_HUMAN); P25039 (EFGM_YEAST): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
EFGM
Protein name
RecName: Full=Elongation factor G, mitochondrial;
Short=EF-Gmt;
AltName: Full=Elongation factor G 1, mitochondrial;
Short=mEF-G 1;
AltName: Full=Elongation factor G1;
case <OC:Vertebrata>
Gene name
GFM1, EFG1
else case <OC:Fungi>
Gene name
MEF1
end case

Comments [?]

case <OC:Vertebrata>
Function Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.
else
Function Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
end case
Pathway Protein biosynthesis; polypeptide chain elongation.
Subcellular location Mitochondrion.
case <OC:Saccharomyces>
Ptm The precursor is processed in two steps involving mitochondrial intermediate peptidase (MIP) and mitochondrial processing peptidase (MPP).
end case
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003746; Molecular function: translation elongation factor activity.
GO:0003924; Molecular function: GTPase activity.
GO:0005525; Molecular function: GTP binding.
GO:0070125; Biological process: mitochondrial translational elongation.
GO:0005739; Cellular component: mitochondrion.

Cross-references [?]

PROSITE PS00301; G_TR_1; 1;
Pfam PF00679; EFG_C; 1;
PF03764; EFG_IV; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
PRINTS PR00315; ELONGATNFCT; 1;
TIGRFAMs TIGR00484; EF-G; 1;
TIGR00231; small_GTP; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: EFGM_HUMAN (Q96RP9)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     53     60       GTP     [AS]-H-[IV]-D-[AS]-G-K-T  
NP_BIND     120     124       GTP     D-T-P-G-H  
NP_BIND     174     177       GTP     N-K-x-D  

Additional information [?]

Size range 669-872 amino acids
Related rules MF_03063 (EFGC supersedes the current rule)
Fusion None