 |
|
Annotation rule MF_03064 |
General rule information
[?]
Accession |
MF_03064 |
Dates |
3-JUN-2009 (Created) 20-NOV-2019 (Last updated, Version 9) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Vertebrata>
Protein name |
RecName:
|
Full=Mitochondrial glycine transporter;
|
AltName:
|
Full=Solute carrier family 25 member 38;
|
|
else
Protein name |
RecName:
|
Full=Mitochondrial glycine transporter;
|
AltName:
|
Full=Solute carrier family 25 member 38 homolog;
|
|
end case
case <OC:Vertebrata>
Function |
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. |
else
Function |
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. |
end case
Subcellular location |
Mitochondrion inner membrane; Multi-pass membrane protein. |
Similarity |
Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. |
GO:0015187; Molecular function: glycine transmembrane transporter activity.
GO:1904983; Biological process: glycine import into mitochondrion.
case <OC:Vertebrata>
GO:0030218; Biological process: erythrocyte differentiation.
end case
GO:0016021; Cellular component: integral component of membrane.
GO:0005743; Cellular component: mitochondrial inner membrane.
General |
Transmembrane; -; 0-6; |
From: S2538_HUMAN (Q96DW6) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
TRANSMEM
|
|
31
|
|
56
|
|
Helical; Name=1
|
|
|
|
|
|
|
TRANSMEM
|
|
89
|
|
115
|
|
Helical; Name=2
|
|
|
|
|
|
|
TRANSMEM
|
|
127
|
|
152
|
|
Helical; Name=3
|
|
|
|
|
|
|
TRANSMEM
|
|
180
|
|
203
|
|
Helical; Name=4
|
|
|
|
|
|
|
TRANSMEM
|
|
219
|
|
245
|
|
Helical; Name=5
|
|
|
|
|
|
|
TRANSMEM
|
|
274
|
|
292
|
|
Helical; Name=6
|
|
|
|
|
|
|
Additional information
[?]
Size range |
287-362 amino acids |
Related rules |
None |
Fusion |
None |