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Annotation rule MF_03064
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General rule information [?]

Accession MF_03064
Dates 3-JUN-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name SLC25A38
Scope
Eukaryota
Templates Q96DW6 (S2538_HUMAN); Q07534 (S2538_YEAST): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
S2538
case <OC:Vertebrata>
Protein name
RecName: Full=Mitochondrial glycine transporter;
AltName: Full=Solute carrier family 25 member 38;
Gene name
SLC25A38
else
Protein name
RecName: Full=Mitochondrial glycine transporter;
AltName: Full=Solute carrier family 25 member 38 homolog;
end case

Comments [?]

case <OC:Vertebrata>
Function Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
else
Function Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.
end case
Subcellular location Mitochondrion inner membrane; Multi-pass membrane protein.
Similarity Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0015187; Molecular function: glycine transmembrane transporter activity.
GO:1904983; Biological process: glycine import into mitochondrion.
case <OC:Vertebrata>
GO:0030218; Biological process: erythrocyte differentiation.
end case
GO:0016021; Cellular component: integral component of membrane.
GO:0005743; Cellular component: mitochondrial inner membrane.

Cross-references [?]

PROSITE PS50920; SOLCAR; 3; trigger=PRU00282;
Pfam PF00153; Mito_carr; 3;
PRINTS PR00926; MITOCARRIER; 1;

Computed features [?]

General Transmembrane; -; 0-6;

Features [?]

From: S2538_HUMAN (Q96DW6)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     31     56       Helical; Name=1        
TRANSMEM     89     115       Helical; Name=2        
TRANSMEM     127     152       Helical; Name=3        
TRANSMEM     180     203       Helical; Name=4        
TRANSMEM     219     245       Helical; Name=5        
TRANSMEM     274     292       Helical; Name=6        

Additional information [?]

Size range 287-362 amino acids
Related rules None
Fusion None