 |
|
| Annotation rule MF_03064 |
General rule information
[?]
| Accession | MF_03064 |
| Dates | 3-JUN-2009 (Created) 20-NOV-2019 (Last updated, Version 9) |
| Name | SLC25A38 |
| Scope | Eukaryota |
| Templates | Q96DW6 (S2538_HUMAN); Q07534 (S2538_YEAST): [Recover all] |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
case <OC:Vertebrata>
| Protein name |
|
||||||||
| Gene name |
|
else
| Protein name |
|
||||||||
end case
Comments
[?]
case <OC:Vertebrata>
| Function | Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. |
else
| Function | Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. |
end case
| Subcellular location | Mitochondrion inner membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. |
Keywords
[?]
Membrane
Mitochondrion
Mitochondrion inner membrane
Repeat
Transmembrane
Transmembrane helix
Transport
Mitochondrion
Mitochondrion inner membrane
Repeat
Transmembrane
Transmembrane helix
Transport
Gene Ontology
[?]
GO:0015187; Molecular function: glycine transmembrane transporter activity.
GO:1904983; Biological process: glycine import into mitochondrion.
GO:1904983; Biological process: glycine import into mitochondrion.
case <OC:Vertebrata>
GO:0030218; Biological process: erythrocyte differentiation.
end case
GO:0016021; Cellular component: integral component of membrane.
GO:0005743; Cellular component: mitochondrial inner membrane.
GO:0005743; Cellular component: mitochondrial inner membrane.
Cross-references
[?]
| PROSITE | PS50920; SOLCAR; 3; trigger=PRU00282; |
| Pfam | PF00153; Mito_carr; 3; |
| PRINTS | PR00926; MITOCARRIER; 1; |
Computed features
[?]
| General | Transmembrane; -; 0-6; |
Features
[?]
| From: S2538_HUMAN (Q96DW6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 31 | 56 | Helical; Name=1 | |||||||||
| TRANSMEM | 89 | 115 | Helical; Name=2 | |||||||||
| TRANSMEM | 127 | 152 | Helical; Name=3 | |||||||||
| TRANSMEM | 180 | 203 | Helical; Name=4 | |||||||||
| TRANSMEM | 219 | 245 | Helical; Name=5 | |||||||||
| TRANSMEM | 274 | 292 | Helical; Name=6 | |||||||||
Additional information
[?]
| Size range | 287-362 amino acids |
| Related rules | None |
| Fusion | None |