HAMAP rule MF_03068
General rule information
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Accession | MF_03068 |
Dates | 19-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 4) |
Name | DHX29 |
Scope | Eukaryota; Vertebrata |
Template | Q7Z478 (DHX29_HUMAN) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Mammalia>
Protein name |
|
else
Protein name |
|
end case
Gene name |
|
Comments
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Function | ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. |
case <OC:Mammalia>
Subunit | Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit. |
else
Subunit | Part of the 43S pre-initiation complex (PIC). |
end case
Catalytic activity | RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.13 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the DEAD box helicase family. DEAH subfamily. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
GO:0003724; Molecular function: RNA helicase activity.
GO:0045948; Biological process: positive regulation of translational initiation.
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
GO:0003724; Molecular function: RNA helicase activity.
GO:0045948; Biological process: positive regulation of translational initiation.
Cross-references
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PROSITE | PS00690; DEAH_ATP_HELICASE; 1; |
PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541; | |
PS51194; HELICASE_CTER; 1; trigger=PRU00542; |
Computed features
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General | Coiled_coil; -; 0-unlimited; trigger=yes; |
Additional information
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Size range | 1300-1400 amino acids |
Related rules | None |
Fusion | None |