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HAMAP rule MF_03068

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General rule information [?]

Accession MF_03068
Dates 19-FEB-2009 (Created)
20-NOV-2019 (Last updated, Version 4)
Name DHX29
Scope
Eukaryota; Vertebrata
Template Q7Z478 (DHX29_HUMAN)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DHX29
case <OC:Mammalia>
Protein name
RecName: Full=ATP-dependent RNA helicase DHX29;
EC 3.6.4.13;
AltName: Full=DEAH box protein 29;
else
Protein name
RecName: Full=ATP-dependent RNA helicase ;
EC 3.6.4.13;
AltName: Full=DEAH box protein 29;
end case
Gene name
DHX29

Comments [?]

Function ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
case <OC:Mammalia>
Subunit Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.
else
Subunit Part of the 43S pre-initiation complex (PIC).
end case
Catalytic activity RHEA:13065: ATP + H2O = ADP + H(+) + phosphate
EC 3.6.4.13
Subcellular location Cytoplasm.
Similarity Belongs to the DEAD box helicase family. DEAH subfamily.

Keywords [?]

ATP-binding
Cytoplasm
Helicase
Hydrolase
Initiation factor
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0016818; Molecular function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides.
GO:0003724; Molecular function: RNA helicase activity.
GO:0045948; Biological process: positive regulation of translational initiation.

Cross-references [?]

PROSITE PS00690; DEAH_ATP_HELICASE; 1;
PS51192; HELICASE_ATP_BIND_1; 1; trigger=PRU00541;
PS51194; HELICASE_CTER; 1; trigger=PRU00542;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Additional information [?]

Size range 1300-1400 amino acids
Related rules None
Fusion None


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