HAMAP rule MF_03068

General rule information [?]

Accession	MF_03068
Dates	19-FEB-2009 (Created) 20-NOV-2019 (Last updated, Version 4)
Name	DHX29
Scope(s)	Eukaryota Vertebrata
Template(s)	Q7Z478 (DHX29_HUMAN); [ Recover all ]
Triggered by	HAMAP; MF_03068 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	DHX29
case <OC:Mammalia>
RecName: Full=ATP-dependent RNA helicase DHX29;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;<br /> AltName: Full=DEAH box protein 29;
else
RecName: Full=ATP-dependent RNA helicase <gene_name>;<br />                  EC=<a href="https://enzyme.expasy.org/EC/3.6.4.13">3.6.4.13</a>;<br /> AltName: Full=DEAH box protein 29;
end case
Gene name	Name=DHX29;

Comments [?]

FUNCTION	ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
case <OC:Mammalia>
SUBUNIT	Part of the 43S pre-initiation complex (PIC) that contains at least Met-tRNA, EIF1, EIF1A (EIF1AX or EIF1AY), EIF2S1, EIF2S2, EIF2S3, EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L, EIF3M, DHX29 and the 40S ribosomal subunit.
else
SUBUNIT	Part of the 43S pre-initiation complex (PIC).
end case
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the DEAD box helicase family. DEAH subfamily.

Keywords [?]

ATP-binding
Cytoplasm
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Initiation factor
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0016818; Molecular function:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO:0003724; Molecular function:RNA helicase activity

GO:0045948; Biological process:positive regulation of translational initiation

Cross-references [?]

Features [?]

Additional information [?]