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HAMAP rule MF_03069

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General rule information [?]

Accession MF_03069
Dates 6-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 5)
Name Kintoun
Scope
Eukaryota
Templates Q9NVR5 (KTU_HUMAN); Q8BPI1 (KTU_MOUSE); B6F1W5 (KTU_ORYLA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KTU
case <OC:Vertebrata>
Protein name
RecName: Full=Protein kintoun;
AltName: Full=Dynein assembly factor 2, axonemal;
else case <OC:Drosophilidae>
Protein name
RecName: Full=Protein kintoun;
AltName: Full=Dynein assembly factor 2, axonemal homolog;
AltName: Full=PP1-interacting protein 20;
else
Protein name
RecName: Full=Protein kintoun;
AltName: Full=Dynein assembly factor 2, axonemal homolog;
end case
case <OC:Vertebrata>
Gene name
DNAAF2, KTU
else case <OC:Drosophilidae>
Gene name
Nop17l, Ppi20
end case

Comments [?]

Function Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
case <OC:Mammalia>
Subunit Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
else case <OC:Drosophilidae>
Subunit Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw.
end case
case <OC:Vertebrata>
Subcellular location Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
else
Subcellular location Cytoplasm.
end case
Similarity Belongs to the PIH1 family. Kintoun subfamily.

Keywords [?]

Cytoplasm

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0060285; Biological process: cilium-dependent cell motility.
GO:0070286; Biological process: axonemal dynein complex assembly.

Cross-references [?]

Pfam PF08190; PIH1; 1;

Additional information [?]

Size range 566-906 amino acids
Related rules None
Fusion None


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