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Annotation rule MF_03069 |
General rule information
[?]
Accession |
MF_03069 |
Dates |
6-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 5) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Vertebrata>
Protein name |
RecName:
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Full=Protein kintoun;
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AltName:
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Full=Dynein assembly factor 2, axonemal;
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else case <OC:Drosophilidae>
Protein name |
RecName:
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Full=Protein kintoun;
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AltName:
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Full=Dynein assembly factor 2, axonemal homolog;
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AltName:
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Full=PP1-interacting protein 20;
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else
Protein name |
RecName:
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Full=Protein kintoun;
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AltName:
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Full=Dynein assembly factor 2, axonemal homolog;
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end case
case <OC:Vertebrata>
else case <OC:Drosophilidae>
end case
Function |
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. |
case <OC:Mammalia>
Subunit |
Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3. |
else case <OC:Drosophilidae>
Subunit |
Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw. |
end case
case <OC:Vertebrata>
Subcellular location |
Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. |
else
Subcellular location |
Cytoplasm. |
end case
Similarity |
Belongs to the PIH1 family. Kintoun subfamily. |
GO:0005737; Cellular component: cytoplasm.
GO:0060285; Biological process: cilium-dependent cell motility.
GO:0070286; Biological process: axonemal dynein complex assembly.
Additional information
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Size range |
566-906 amino acids |
Related rules |
None |
Fusion |
None |