HAMAP rule MF_03069
General rule information
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Accession | MF_03069 |
Dates | 6-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 5) |
Name | Kintoun |
Scope | Eukaryota |
Templates | Q9NVR5 (KTU_HUMAN); Q8BPI1 (KTU_MOUSE); B6F1W5 (KTU_ORYLA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Vertebrata>
Protein name |
|
else case <OC:Drosophilidae>
Protein name |
|
else
Protein name |
|
end case
case <OC:Vertebrata>
Gene name |
|
else case <OC:Drosophilidae>
Gene name |
|
end case
Comments
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Function | Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. |
case <OC:Mammalia>
Subunit | Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3. |
else case <OC:Drosophilidae>
Subunit | Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw. |
end case
case <OC:Vertebrata>
Subcellular location | Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia. |
else
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the PIH1 family. Kintoun subfamily. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component: cytoplasm.
GO:0060285; Biological process: cilium-dependent cell motility.
GO:0070286; Biological process: axonemal dynein complex assembly.
GO:0060285; Biological process: cilium-dependent cell motility.
GO:0070286; Biological process: axonemal dynein complex assembly.
Cross-references
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Pfam | PF08190; PIH1; 1; |
Additional information
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Size range | 566-906 amino acids |
Related rules | None |
Fusion | None |