HAMAP rule MF_03069

General rule information [?]

Accession	MF_03069
Dates	6-MAR-2009 (Created) 20-NOV-2019 (Last updated, Version 5)
Name	Kintoun
Scope(s)	Eukaryota
Template(s)	Q9NVR5 (KTU_HUMAN); Q8BPI1 (KTU_MOUSE); B6F1W5 (KTU_ORYLA); [ Recover all ]
Triggered by	HAMAP; MF_03069 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KTU
case <OC:Vertebrata>
Protein name	RecName: Full=Protein kintoun; AltName: Full=Dynein assembly factor 2, axonemal;
else case <OC:Drosophilidae>
Protein name	RecName: Full=Protein kintoun; AltName: Full=Dynein assembly factor 2, axonemal homolog; AltName: Full=PP1-interacting protein 20;
else
Protein name	RecName: Full=Protein kintoun; AltName: Full=Dynein assembly factor 2, axonemal homolog;
end case
case <OC:Vertebrata>
Gene name	Name=DNAAF2; Synonyms=KTU;
else case <OC:Drosophilidae>
Gene name	Name=Nop17l; Synonyms=Ppi20;
end case

Comments [?]

FUNCTION	Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.
case <OC:Mammalia>
SUBUNIT	Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
else case <OC:Drosophilidae>
SUBUNIT	Interacts with Pp1alpha-96A, Pp1-87B, Pp1-13C and flw.
end case
case <OC:Vertebrata>
SUBCELLULAR LOCATION	Cytoplasm. Note=Localizes in the apical cytoplasm around the gamma-tubulin-positive pericentriolar region, not in the cilia.
else
SUBCELLULAR LOCATION	Cytoplasm.
end case
SIMILARITY	Belongs to the PIH1 family. Kintoun subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005737; Cellular component:cytoplasm

GO:0060285; Biological process:cilium-dependent cell motility

GO:0070286; Biological process:axonemal dynein complex assembly

Cross-references [?]

Pfam	PF08190; PIH1; 1;

Features [?]

Additional information [?]