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Annotation rule MF_03070
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General rule information [?]

Accession MF_03070
Dates 5-MAR-2009 (Created)
20-NOV-2019 (Last updated, Version 3)
Name SCARA5
Scope
Eukaryota; Vertebrata
Template Q8K299 (SCAR5_MOUSE)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SCAR5
Protein name
RecName: Full=Scavenger receptor class A member 5;
Gene name
SCARA5

Comments [?]

case <OC:Mammalia>
Function Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
else
Function Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways.
end case
Subunit Homotrimer.
Subcellular location Cell membrane; Single-pass type II membrane protein.
Similarity Belongs to the SCARA5 family.

Keywords [?]


Gene Ontology [?]

GO:0016021; Cellular component: integral component of membrane.
GO:0005886; Cellular component: plasma membrane.
GO:0070287; Molecular function: ferritin receptor activity.
GO:0006879; Biological process: cellular iron ion homeostasis.
GO:0034755; Biological process: iron ion transmembrane transport.
GO:0006897; Biological process: endocytosis.

Cross-references [?]

PROSITE PS00420; SRCR_1; 1;
PS50287; SRCR_2; 1; trigger=PRU00196;
Pfam PF01391; Collagen; 1; trigger=Yes;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;
case <OC:Homo>
N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes;

Cross-references [?]

else
PROSITE PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=PRU00498;
end case

Features [?]

From: SCAR5_MOUSE (Q8K299)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     60       Cytoplasmic        
TRANSMEM     61     81       Helical; Signal-anchor for type II membrane protein        
TOPO_DOM     82     Cter       Extracellular        

Additional information [?]

Size range 491-499 amino acids
Related rules None
Fusion None