HAMAP rule MF_03070

General rule information [?]

Accession	MF_03070
Dates	5-MAR-2009 (Created) 7-FEB-2023 (Last updated, Version 5)
Name	SCARA5
Scope(s)	Eukaryota Vertebrata
Template(s)	Q8K299 (SCAR5_MOUSE); [ Recover all ]
Triggered by	HAMAP; MF_03070 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SCAR5
Protein name	RecName: Full=Scavenger receptor class A member 5;
Gene name	Name=SCARA5;

Comments [?]

case <OC:Mammalia>
FUNCTION	Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
else
FUNCTION	Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways.
end case
SUBUNIT	Homotrimer.
SUBCELLULAR LOCATION	Cell membrane; Single-pass type II membrane protein.
SIMILARITY	Belongs to the SCARA5 family.

Keywords [?]

Gene Ontology [?]

GO:0016020; Cellular component:membrane

GO:0005886; Cellular component:plasma membrane

GO:0070287; Molecular function:ferritin receptor activity

GO:0006879; Biological process:intracellular iron ion homeostasis

GO:0034755; Biological process:iron ion transmembrane transport

GO:0006897; Biological process:endocytosis

Cross-references [?]

PROSITE	PS00420; SRCR_1; 1;
PROSITE	PS50287; SRCR_2; 1;
Pfam	PF01391; Collagen; 1;
General	Coiled_coil; -; 0-unlimited;
General	N_glycosylation; NetNGlyc; 0-unlimited;
PROSITE	PS00001; ASN_GLYCOSYLATION; 0-unlimited;

Features [?]

From: SCAR5_MOUSE (Q8K299)

Key

From

Description

Tag

Condition

FTGroup

TOPO_DOM

Nter

/note="Cytoplasmic"

TRANSMEM

/note="Helical; Signal-anchor for type II membrane protein"

TOPO_DOM

Cter

/note="Extracellular"

Additional information [?]