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Annotation rule MF_03070 |
Accession | MF_03070 |
Dates | 5-MAR-2009 (Created) 29-SEP-2022 (Last updated, Version 4) |
Name | SCARA5 |
Scope | Eukaryota; Vertebrata |
Template | Q8K299 (SCAR5_MOUSE) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). |
Function | Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. |
Subunit | Homotrimer. |
Subcellular location | Cell membrane; Single-pass type II membrane protein. |
Similarity | Belongs to the SCARA5 family. |
PROSITE | PS00420; SRCR_1; 1; |
PS50287; SRCR_2; 1; trigger=PRU00196; | |
Pfam | PF01391; Collagen; 1; trigger=Yes; |
General | Coiled_coil; -; 0-unlimited; trigger=yes; |
N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes; |
From: SCAR5_MOUSE (Q8K299) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TOPO_DOM | Nter | 60 | Cytoplasmic | |||||||||
TRANSMEM | 61 | 81 | Helical; Signal-anchor for type II membrane protein | |||||||||
TOPO_DOM | 82 | Cter | Extracellular |
Size range | 491-499 amino acids |
Related rules | None |
Fusion | None |