HAMAP rule MF_03070
General rule information
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| Accession | MF_03070 |
| Dates | 5-MAR-2009 (Created) 7-FEB-2023 (Last updated, Version 5) |
| Name | SCARA5 |
| Scope | Eukaryota; Vertebrata |
| Template | Q8K299 (SCAR5_MOUSE) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Mammalia>
| Function | Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1). |
else
| Function | Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. |
end case
| Subunit | Homotrimer. |
| Subcellular location | Cell membrane; Single-pass type II membrane protein. |
| Similarity | Belongs to the SCARA5 family. |
Keywords
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Cell membrane
Ion transport
Iron
Iron transport
Membrane
Receptor
Signal-anchor
Transmembrane
Transmembrane helix
Transport
Ion transport
Iron
Iron transport
Membrane
Receptor
Signal-anchor
Transmembrane
Transmembrane helix
Transport
Gene Ontology
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GO:0016020; Cellular component: membrane.
GO:0005886; Cellular component: plasma membrane.
GO:0070287; Molecular function: ferritin receptor activity.
GO:0006879; Biological process: intracellular iron ion homeostasis.
GO:0034755; Biological process: iron ion transmembrane transport.
GO:0006897; Biological process: endocytosis.
GO:0005886; Cellular component: plasma membrane.
GO:0070287; Molecular function: ferritin receptor activity.
GO:0006879; Biological process: intracellular iron ion homeostasis.
GO:0034755; Biological process: iron ion transmembrane transport.
GO:0006897; Biological process: endocytosis.
Cross-references
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| PROSITE | PS00420; SRCR_1; 1; |
| PS50287; SRCR_2; 1; trigger=PRU00196; | |
| Pfam | PF01391; Collagen; 1; trigger=Yes; |
Computed features
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| General | Coiled_coil; -; 0-unlimited; trigger=yes; |
case <OC:Homo>
| N_glycosylation; NetNGlyc; 0-unlimited; trigger=yes; |
Cross-references
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else
end case
Features
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| From: SCAR5_MOUSE (Q8K299) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 60 | Cytoplasmic | |||||||||
| TRANSMEM | 61 | 81 | Helical; Signal-anchor for type II membrane protein | |||||||||
| TOPO_DOM | 82 | Cter | Extracellular | |||||||||
Additional information
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| Size range | 491-499 amino acids |
| Related rules | None |
| Fusion | None |