HAMAP rule MF_03100
General rule information
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| Accession | MF_03100 |
| Dates | 17-AUG-2009 (Created) 7-FEB-2023 (Last updated, Version 10) |
| Name | Endonuc_su_Slx1 |
| Scope | Eukaryota |
| Templates | P38324 (SLX1_YEAST); Q9BQ83 (SLX1_HUMAN); Q9P7M3 (SLX1_SCHPO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
case <OC:Vertebrata>
| Protein name |
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else case <OC:Caenorhabditis>
| Protein name |
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else case <OC:Fungi>
| Protein name |
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else
| Protein name |
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end case
case <OC:Vertebrata>
| Gene name |
|
else case <OC:Caenorhabditis>
| Gene name |
|
else case <OC:Fungi>
| Gene name |
|
end case
Comments
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case <OC:Mammalia>
| Function | Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. |
else case <OC:Vertebrata> and not <OC:Mammalia>
| Function | Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. |
else case <OC:Saccharomyces>
| Function | Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro. |
else case <OC:Fungi> and not <OC:Saccharomyces>
| Function | Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. |
else
| Function | Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. |
end case
| Cofactor | a divalent metal cation |
case <OC:Vertebrata> or <OC:Fungi>
| Subunit | Forms a heterodimer with @gn(SLX4). |
else case <OC:Drosophilidae>
| Subunit | Forms a heterodimer with mus312/SLX4. |
else case <OC:Caenorhabditis>
| Subunit | Forms a heterodimer with him-18/slx-4. |
else
| Subunit | Forms a heterodimer with a member of the SLX4 family. |
end case
| Subcellular location | Nucleus. |
| Similarity | Belongs to the SLX1 family. |
Keywords
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case <FT:1>
end case
Gene Ontology
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case <OC:Mammalia>
GO:0008821; Molecular function: crossover junction DNA endonuclease activity.
end case
case <OC:Mammalia> or <OC:Saccharomyces>
GO:0017108; Molecular function: 5'-flap endonuclease activity.
else
GO:0004520; Molecular function: DNA endonuclease activity.
end case
Cross-references
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| PROSITE | PS50164; GIY_YIG; 1; trigger=PRU00977; |
| PS01359; ZF_PHD_1; 0-1; | |
| PS50016; ZF_PHD_2; 0-1; | |
| Pfam | PF01541; GIY-YIG; 0-1; |
Features
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| From: SLX1_HUMAN (Q9BQ83) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ZN_FING | 186 | 238 | SLX1-type | C-x(1,2)-C-x*-C-x(1,7)-C-x(1,4)-[CH]-x(2)-C-x*-C-x(2)-C | ||||||||
Additional information
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| Size range | 246-705 amino acids |
| Related rules | None |
| Fusion | None |