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Annotation rule MF_03100
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General rule information [?]

Accession MF_03100
Dates 17-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 9)
Name Endonuc_su_Slx1
Scope
Eukaryota
Templates P38324 (SLX1_YEAST); Q9BQ83 (SLX1_HUMAN); Q9P7M3 (SLX1_SCHPO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SLX1
case <OC:Vertebrata>
Protein name
RecName: Full=Structure-specific endonuclease subunit ;
EC 3.1.-.-;
AltName: Full=GIY-YIG domain-containing protein 1;
else case <OC:Caenorhabditis>
Protein name
RecName: Full=Structure-specific endonuclease subunit ;
EC 3.1.-.-;
AltName: Full=GIY-YIG domain-containing protein 1;
else case <OC:Fungi>
Protein name
RecName: Full=Structure-specific endonuclease subunit ;
EC 3.1.-.-;
else
Protein name
RecName: Full=Structure-specific endonuclease subunit SLX1 homolog;
EC 3.1.-.-;
end case
case <OC:Vertebrata>
Gene name
SLX1, GIYD1
else case <OC:Caenorhabditis>
Gene name
slx-1, giyd-1
else case <OC:Fungi>
Gene name
SLX1
end case

Comments [?]

case <OC:Mammalia>
Function Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
else case <OC:Vertebrata> and not <OC:Mammalia>
Function Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
else case <OC:Saccharomyces>
Function Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for simple Y, 5'-flap and replication fork-like structures. It cleaves the strand bearing the 5'-non-homologous arm at the branch site junction and generates ligatable, nicked products from the 5'-flap or replication fork substrates. Plays a critical role in maintaining the integrity of the ribosomal DNA (rDNA) loci, where it has a role in re-starting stalled replication forks. Has Holliday junction resolvase activity in vitro.
else case <OC:Fungi> and not <OC:Saccharomyces>
Function Catalytic subunit of the @gn(SLX1)-@gn(SLX4) structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
else
Function Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
end case
case <OC:Vertebrata> or <OC:Fungi>
Subunit Forms a heterodimer with @gn(SLX4).
else case <OC:Drosophilidae>
Subunit Forms a heterodimer with mus312/SLX4.
else case <OC:Caenorhabditis>
Subunit Forms a heterodimer with him-18/slx-4.
else
Subunit Forms a heterodimer with a member of the SLX4 family.
end case
Subcellular location Nucleus.
Similarity Belongs to the SLX1 family.

Keywords [?]

case <FT:1>
end case

Gene Ontology [?]

GO:0005634; Cellular component: nucleus.
GO:0033557; Cellular component: Slx1-Slx4 complex.
case <OC:Mammalia>
GO:0008821; Molecular function: crossover junction endodeoxyribonuclease activity.
end case
case <OC:Mammalia> or <OC:Saccharomyces>
GO:0017108; Molecular function: 5'-flap endonuclease activity.
else
GO:0004520; Molecular function: endodeoxyribonuclease activity.
end case
GO:0006310; Biological process: DNA recombination.
GO:0006281; Biological process: DNA repair.

Cross-references [?]

PROSITE PS50164; GIY_YIG; 1; trigger=PRU00977;
PS01359; ZF_PHD_1; 0-1;
PS50016; ZF_PHD_2; 0-1;
Pfam PF01541; GIY-YIG; 0-1;

Features [?]

From: SLX1_HUMAN (Q9BQ83)
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     186     238       SLX1-type     C-x(1,2)-C-x*-C-x(1,7)-C-x(1,4)-[CH]-x(2)-C-x*-C-x(2)-C  

Additional information [?]

Size range 246-705 amino acids
Related rules None
Fusion None