HAMAP rule MF_03102

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03102
Accession	MF_03102
Dates	02-OCT-2012 (Created) 29-SEP-2022 (Last updated, Version 10)
Name	Mdm10
Scope(s)	Eukaryota Fungi
Template(s)	P18409; [ Recover all ]
Triggered by	HAMAP; MF_03102 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MDM10
Protein name	RecName: Full=Mitochondrial distribution and morphology protein 10; AltName: Full=Mitochondrial inheritance component ;
Gene name	Name=MDM10;

Comments [?]

FUNCTION	Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the @gn(TOM40)-specific route of the assembly of outer membrane beta-barrel proteins, including the association of @gn(TOM40) with the receptor @gn(TOM22) and small TOM proteins. Can associate with the SAM(core) complex as well as the @gn(MDM12)-@gn(MMM1) complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the @gn(TOM40)-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
case <OC:Saccharomyces>
SUBUNIT	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, , MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50, to form a SAM(holo) complex.
else
SUBUNIT	Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), , @gn(MDM12) and @gn(MDM34). Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
end case
SUBCELLULAR LOCATION	Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
DOMAIN	Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
SIMILARITY	Belongs to the MDM10 family.

Keywords [?]

Membrane

Mitochondrion

Mitochondrion outer membrane

Transmembrane

Transmembrane beta strand

Gene Ontology [?]

GO:0005741; Cellular component:mitochondrial outer membrane

GO:0032865; Cellular component:ERMES complex

GO:0000002; Biological process:mitochondrial genome maintenance

GO:0070096; Biological process:mitochondrial outer membrane translocase complex assembly

GO:1990456; Biological process:mitochondrion-endoplasmic reticulum membrane tethering

GO:0045040; Biological process:protein insertion into mitochondrial outer membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	184-646 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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