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Annotation rule MF_03102
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General rule information [?]

Accession MF_03102
Dates 14-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name Mdm10
Scope
Eukaryota; Fungi
Template P18409 (MDM10_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDM10
Protein name
RecName: Full=Mitochondrial distribution and morphology protein 10;
AltName: Full=Mitochondrial inheritance component ;
Gene name
MDM10

Comments [?]

Function Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the @gn(TOM40)-specific route of the assembly of outer membrane beta-barrel proteins, including the association of @gn(TOM40) with the receptor @gn(TOM22) and small TOM proteins. Can associate with the SAM(core) complex as well as the @gn(MDM12)-@gn(MMM1) complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the @gn(TOM40)-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.
case <OC:Saccharomyces>
Subunit Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, , MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex, which consists of SAM35, SAM37 and SAM50, to form a SAM(holo) complex.
else
Subunit Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), , @gn(MDM12) and @gn(MDM34). Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.
end case
Subcellular location Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Domain Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.
Similarity Belongs to the MDM10 family.

Keywords [?]

Membrane
Mitochondrion
Mitochondrion outer membrane
Transmembrane
Transmembrane beta strand

Gene Ontology [?]

GO:0031307; Cellular component: integral component of mitochondrial outer membrane.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0070096; Biological process: mitochondrial outer membrane translocase complex assembly.
GO:1990456; Biological process: mitochondrion-endoplasmic reticulum membrane tethering.
GO:0045040; Biological process: protein insertion into mitochondrial outer membrane.

Additional information [?]

Size range 184-646 amino acids
Related rules None
Fusion None


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