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Annotation rule MF_03102 |
Accession | MF_03102 |
Dates | 14-AUG-2009 (Created) 20-NOV-2019 (Last updated, Version 8) |
Name | Mdm10 |
Scope | Eukaryota; Fungi |
Template | P18409 (MDM10_YEAST) |
Triggered by |
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Function | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. |
Subunit | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, |
Subunit | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), |
Subcellular location | Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. |
Domain | Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin. |
Similarity | Belongs to the MDM10 family. |
Size range | 184-646 amino acids |
Related rules | None |
Fusion | None |