HAMAP rule MF_03102
General rule information
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Accession | MF_03102 |
Dates | 14-AUG-2009 (Created)
29-SEP-2022 (Last updated, Version 9) |
Name | Mdm10 |
Scope(s) |
Eukaryota Fungi |
Template(s) | P18409 (MDM10_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03102 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MDM10 |
Protein name | RecName: Full=Mitochondrial distribution and morphology protein 10; AltName: Full=Mitochondrial inheritance component |
Gene name | Name=MDM10; |
Comments
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FUNCTION | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. |
case <OC:Saccharomyces> | |
SUBUNIT | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, |
else | |
SUBUNIT | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), |
end case | |
SUBCELLULAR LOCATION | Mitochondrion outer membrane; Multi-pass membrane protein. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. |
DOMAIN | Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin. |
SIMILARITY | Belongs to the MDM10 family. |
Keywords
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Gene Ontology
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GO:0005741; Cellular component:mitochondrial outer membrane |
GO:0032865; Cellular component:ERMES complex |
GO:0000002; Biological process:mitochondrial genome maintenance |
GO:0070096; Biological process:mitochondrial outer membrane translocase complex assembly |
GO:1990456; Biological process:mitochondrion-endoplasmic reticulum membrane tethering |
GO:0045040; Biological process:protein insertion into mitochondrial outer membrane |
Cross-references
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Features
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Additional information
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Size range | 184-646 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |