HAMAP rule MF_03104
General rule information
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Accession | MF_03104 |
Dates | 14-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 8) |
Name | Mdm12 |
Scope(s) |
Eukaryota Fungi |
Template(s) | Q92328 (MDM12_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03104 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MDM12 |
Protein name | RecName: Full=Mitochondrial distribution and morphology protein 12; AltName: Full=Mitochondrial inheritance component |
Gene name | Name=MDM12; |
Comments
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FUNCTION | Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. |
case <OC:Saccharomyces> | |
SUBUNIT | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), |
else | |
SUBUNIT | Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), |
end case | |
SUBCELLULAR LOCATION | Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids. |
SIMILARITY | Belongs to the MDM12 family. |
Keywords
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Gene Ontology
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GO:0005789; Cellular component:endoplasmic reticulum membrane |
GO:0005741; Cellular component:mitochondrial outer membrane |
GO:0032865; Cellular component:ERMES complex |
GO:0000002; Biological process:mitochondrial genome maintenance |
GO:0045040; Biological process:protein insertion into mitochondrial outer membrane |
Cross-references
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PROSITE | PS51847; SMP; 1; |
Features
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Additional information
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Size range | 239-675 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |