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HAMAP rule MF_03104

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General rule information [?]

Accession MF_03104
Dates 14-AUG-2009 (Created)
20-NOV-2019 (Last updated, Version 8)
Name Mdm12
Scope
Eukaryota; Fungi
Template Q92328 (MDM12_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDM12
Protein name
RecName: Full=Mitochondrial distribution and morphology protein 12;
AltName: Full=Mitochondrial inheritance component ;
Gene name
MDM12

Comments [?]

Function Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. is required for the interaction of the ER-resident membrane protein @gn(MMM1) and the outer mitochondrial membrane-resident beta-barrel protein @gn(MDM10). The -@gn(MMM1) subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The @gn(MDM10)--@gn(MMM1) subcomplex further acts in the @gn(TOM40)-specific pathway after the action of the -@gn(MMM1) complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.
case <OC:Saccharomyces>
Subunit Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), and @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of @gn(MMM1) and generate a continuous hydrophobic tunnel for phospholipid trafficking. Interacts with PUF3.
else
Subunit Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of @gn(MMM1), @gn(MDM10), and @gn(MDM34). A @gn(MMM1) homodimer associates with one molecule of on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of @gn(MMM1) and generate a continuous hydrophobic tunnel for phospholipid trafficking.
end case
Subcellular location Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Note=The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.
Similarity Belongs to the MDM12 family.

Keywords [?]

Endoplasmic reticulum
Membrane
Mitochondrion
Mitochondrion outer membrane

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0005741; Cellular component: mitochondrial outer membrane.
GO:0032865; Cellular component: ERMES complex.
GO:0000002; Biological process: mitochondrial genome maintenance.
GO:0045040; Biological process: protein insertion into mitochondrial outer membrane.

Cross-references [?]

PROSITE PS51847; SMP; 1; trigger=PRU01194;

Additional information [?]

Size range 239-675 amino acids
Related rules None
Fusion None


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