HAMAP rule MF_03107
General rule information
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Accession | MF_03107 |
Dates | 14-AUG-2009 (Created)
14-MAY-2022 (Last updated, Version 9) |
Name | 3_ketoreductase |
Scope(s) |
Eukaryota Fungi |
Template(s) | P38286 (MKAR_YEAST); [ Recover all ] |
Triggered by |
HAMAP; MF_03107 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MKAR |
Protein name | RecName: Full=Very-long-chain 3-oxoacyl-CoA reductase; EC=1.1.1.330; AltName: Full=3-ketoacyl-CoA reductase; Short=3-ketoreductase; Short=KAR; AltName: Full=Microsomal beta-keto-reductase; |
Comments
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FUNCTION | Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. |
CATALYTIC ACTIVITY | Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very- long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330; |
case <OC:Saccharomyces> | |
SUBUNIT | Interacts with the fatty acid elongation system components ELO3 and TSC13. |
end case | |
SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Single-pass membrane protein. |
SIMILARITY | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Keywords
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Endoplasmic reticulum |
Fatty acid biosynthesis |
Fatty acid metabolism |
Lipid biosynthesis |
Lipid metabolism |
Membrane |
NADP |
Oxidoreductase |
Transmembrane |
Transmembrane helix |
Gene Ontology
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GO:0005789; Cellular component:endoplasmic reticulum membrane |
GO:0045703; Molecular function:ketoreductase activity |
GO:0030497; Biological process:fatty acid elongation |
Cross-references
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PROSITE | PS00061; ADH_SHORT; 1; |
Pfam | PF00106; adh_short; 1; |
PRINTS | PR00081; GDHRDH; 1; |
PRINTS | PR00080; SDRFAMILY; 1; |
Features
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From: MKAR_YEAST (P38286) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TRANSMEM | 20 | 40 | /note="Helical" | |||||||||
ACT_SITE | 223 | 223 | /note="Proton acceptor" | Y | ||||||||
BINDING | 210 | 210 | /ligand="substrate" | S |
Additional information
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Size range | 324-395 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |