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Annotation rule MF_03107 |
Accession | MF_03107 |
Dates | 14-AUG-2009 (Created) 31-AUG-2020 (Last updated, Version 8) |
Name | 3_ketoreductase |
Scope | Eukaryota; Fungi |
Template | P38286 (MKAR_YEAST) |
Triggered by |
Identifier |
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Protein name |
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Function | Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. |
Catalytic activity | RHEA:48680: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
EC 1.1.1.330 |
Subunit | Interacts with the fatty acid elongation system components ELO3 and TSC13. |
Subcellular location | Endoplasmic reticulum membrane; Single-pass membrane protein. |
Similarity | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
PROSITE | PS00061; ADH_SHORT; 1; |
Pfam | PF00106; adh_short; 1; |
PRINTS | PR00081; GDHRDH; 1; |
PR00080; SDRFAMILY; 1; |
From: MKAR_YEAST (P38286) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TRANSMEM | 20 | 40 | Helical | |||||||||
ACT_SITE | 223 | 223 | Proton acceptor | Y | ||||||||
BINDING | 210 | 210 | Substrate | S |
Size range | 324-395 amino acids |
Related rules | None |
Fusion | None |