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Annotation rule MF_03107
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General rule information [?]

Accession MF_03107
Dates 14-AUG-2009 (Created)
31-AUG-2020 (Last updated, Version 8)
Name 3_ketoreductase
Scope
Eukaryota; Fungi
Template P38286 (MKAR_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MKAR
Protein name
RecName: Full=Very-long-chain 3-oxoacyl-CoA reductase;
EC 1.1.1.330;
AltName: Full=3-ketoacyl-CoA reductase;
Short=3-ketoreductase;
Short=KAR;
AltName: Full=Microsomal beta-keto-reductase;

Comments [?]

Function Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Catalytic activity RHEA:48680: a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + H(+) + NADPH
EC 1.1.1.330
case <OC:Saccharomyces>
Subunit Interacts with the fatty acid elongation system components ELO3 and TSC13.
end case
Subcellular location Endoplasmic reticulum membrane; Single-pass membrane protein.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords [?]

Endoplasmic reticulum
Fatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
Membrane
NADP
Oxidoreductase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0045703; Molecular function: ketoreductase activity.
GO:0030497; Biological process: fatty acid elongation.

Cross-references [?]

PROSITE PS00061; ADH_SHORT; 1;
Pfam PF00106; adh_short; 1;
PRINTS PR00081; GDHRDH; 1;
PR00080; SDRFAMILY; 1;

Features [?]

From: MKAR_YEAST (P38286)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     20     40       Helical        
ACT_SITE     223     223       Proton acceptor     Y  
BINDING     210     210       Substrate     S  

Additional information [?]

Size range 324-395 amino acids
Related rules None
Fusion None


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