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HAMAP rule MF_03107

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General rule information [?]

Accession MF_03107
Dates 14-AUG-2009 (Created)
14-MAY-2022 (Last updated, Version 9)
Name 3_ketoreductase
Scope(s) Eukaryota
Fungi
Template(s) P38286 (MKAR_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03107 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MKAR
Protein name RecName: Full=Very-long-chain 3-oxoacyl-CoA reductase;
                 EC=1.1.1.330;
AltName: Full=3-ketoacyl-CoA reductase;
                 Short=3-ketoreductase;
                 Short=KAR;
AltName: Full=Microsomal beta-keto-reductase;

Comments [?]

FUNCTIONComponent of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
CATALYTIC ACTIVITY Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very- long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330;
case <OC:Saccharomyces>
SUBUNITInteracts with the fatty acid elongation system components ELO3 and TSC13.
end case
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Single-pass membrane protein.
SIMILARITYBelongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords [?]


Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane
GO:0045703; Molecular function:ketoreductase activity
GO:0030497; Biological process:fatty acid elongation

Cross-references [?]

PROSITE PS00061; ADH_SHORT; 1;
Pfam PF00106; adh_short; 1;
PRINTS PR00081; GDHRDH; 1;
PRINTS PR00080; SDRFAMILY; 1;

Features [?]

From: MKAR_YEAST (P38286)
Key From To Description Tag Condition FTGroup
TRANSMEM 20 40 /note="Helical"
ACT_SITE 223 223 /note="Proton acceptor" Y
BINDING 210 210 /ligand="substrate" S

Additional information [?]

Size range 324-395 amino acids
Related rules None
Fusion Nter: None Cter: None



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