HAMAP rule MF_03107
General rule information
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| Accession | MF_03107 |
| Dates | 14-AUG-2009 (Created)
14-MAY-2022 (Last updated, Version 9) |
| Name | 3_ketoreductase |
| Scope(s) |
Eukaryota Fungi |
| Template(s) | P38286 (MKAR_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03107 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MKAR |
| Protein name | RecName: Full=Very-long-chain 3-oxoacyl-CoA reductase; EC=1.1.1.330; AltName: Full=3-ketoacyl-CoA reductase; Short=3-ketoreductase; Short=KAR; AltName: Full=Microsomal beta-keto-reductase; |
Comments
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| FUNCTION | Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. |
| CATALYTIC ACTIVITY | Reaction=a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very- long-chain 3-oxoacyl-CoA + H(+) + NADPH; Xref=Rhea:RHEA:48680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:85440, ChEBI:CHEBI:90725; EC=1.1.1.330; |
| case <OC:Saccharomyces> | |
| SUBUNIT | Interacts with the fatty acid elongation system components ELO3 and TSC13. |
| end case | |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Single-pass membrane protein. |
| SIMILARITY | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
Keywords
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| Endoplasmic reticulum |
| Fatty acid biosynthesis |
| Fatty acid metabolism |
| Lipid biosynthesis |
| Lipid metabolism |
| Membrane |
| NADP |
| Oxidoreductase |
| Transmembrane |
| Transmembrane helix |
Gene Ontology
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| GO:0005789; Cellular component:endoplasmic reticulum membrane |
| GO:0045703; Molecular function:ketoreductase activity |
| GO:0030497; Biological process:fatty acid elongation |
Cross-references
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| PROSITE | PS00061; ADH_SHORT; 1; |
| Pfam | PF00106; adh_short; 1; |
| PRINTS | PR00081; GDHRDH; 1; |
| PRINTS | PR00080; SDRFAMILY; 1; |
Features
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| From: MKAR_YEAST (P38286) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 20 | 40 | /note="Helical" | |||||||||
| ACT_SITE | 223 | 223 | /note="Proton acceptor" | Y | ||||||||
| BINDING | 210 | 210 | /ligand="substrate" | S | ||||||||
Additional information
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| Size range | 324-395 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |