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Annotation rule MF_03113
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General rule information [?]

Accession MF_03113
Dates 12-OCT-2009 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Get1
Scope
Eukaryota; Fungi
Template P53192 (GET1_YEAST)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GET1
case <OC:Saccharomycotina>
Protein name
RecName: Full=Golgi to ER traffic protein 1;
AltName: Full=Guided entry of tail-anchored proteins 1;
else
Protein name
RecName: Full=Protein ;
AltName: Full=Guided entry of tail-anchored proteins 1;
end case
Gene name
GET1

Comments [?]

case <OC:Saccharomycotina>
Function Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET2), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
Subunit Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3).
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
else
Function Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
Subunit Interacts with @gn(GET3).
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the WRB/GET1 family.

Keywords [?]

case <OC:Saccharomycotina>
end case

Gene Ontology [?]

case <OC:Saccharomycotina>
GO:0043529; Cellular component: GET complex.
else
GO:0005783; Cellular component: endoplasmic reticulum.
end case
GO:0045048; Biological process: protein insertion into ER membrane.

Cross-references [?]

Pfam PF04420; CHD5; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Features [?]

From: GET1_YEAST (P53192)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     1       Lumenal        
TRANSMEM     2     21       Helical        
TOPO_DOM     22     104       Cytoplasmic        
TRANSMEM     105     125       Helical        
TOPO_DOM     126     181       Lumenal        
TRANSMEM     182     198       Helical        
TOPO_DOM     199     Cter       Cytoplasmic        

Additional information [?]

Size range 170-237 amino acids
Related rules None
Fusion None