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HAMAP rule MF_03113

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General rule information [?]

Accession MF_03113
Dates 12-OCT-2009 (Created)
26-FEB-2021 (Last updated, Version 5)
Name Get1
Scope(s) Eukaryota
Fungi
Template(s) P53192 (GET1_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03113 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GET1
case <OC:Saccharomycotina>
Protein name RecName: Full=Golgi to ER traffic protein 1;
AltName: Full=Guided entry of tail-anchored proteins 1;
else
Protein name RecName: Full=Protein ;
AltName: Full=Guided entry of tail-anchored proteins 1;
end case
Gene name Name=GET1;

Comments [?]

case <OC:Saccharomycotina>
FUNCTIONRequired for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET2), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
SUBUNITComponent of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer.
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
else
FUNCTIONRequired for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol.
SUBUNITInteracts with @gn(GET3).
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the WRB/GET1 family.

Keywords [?]


Gene Ontology [?]

case <OCellular component:Saccharomycotina>
GO:0043529; Cellular component:GET complex
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005783; Cellular component:endoplasmic reticulum
end case
GO:0045048; Biological process:protein insertion into ER membrane

Cross-references [?]

Pfam PF04420; CHD5; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: GET1_YEAST (P53192)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 1 /note="Lumenal"
TRANSMEM 2 21 /note="Helical"
TOPO_DOM 22 104 /note="Cytoplasmic"
TRANSMEM 105 125 /note="Helical"
TOPO_DOM 126 181 /note="Lumenal"
TRANSMEM 182 198 /note="Helical"
TOPO_DOM 199 Cter /note="Cytoplasmic"

Additional information [?]

Size range 170-237 amino acids
Related rules None
Fusion Nter: None Cter: None



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