HAMAP rule MF_03113
General rule information
[?]
| Accession | MF_03113 |
| Dates | 12-OCT-2009 (Created) 26-FEB-2021 (Last updated, Version 5) |
| Name | Get1 |
| Scope | Eukaryota; Fungi |
| Template | P53192 (GET1_YEAST) |
| Triggered by |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier |
|
case <OC:Saccharomycotina>
| Protein name |
|
||||||||
else
| Protein name |
|
||||||||
end case
| Gene name |
|
Comments
[?]
case <OC:Saccharomycotina>
| Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET2), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. |
| Subunit | Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
else
| Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. |
| Subunit | Interacts with @gn(GET3). |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the WRB/GET1 family. |
Keywords
[?]
case <OC:Saccharomycotina>
end case
Gene Ontology
[?]
case <OC:Saccharomycotina>
GO:0043529; Cellular component: GET complex.
else
GO:0005783; Cellular component: endoplasmic reticulum.
end case
GO:0045048; Biological process: protein insertion into ER membrane.
Cross-references
[?]
| Pfam | PF04420; CHD5; 1; |
Computed features
[?]
| General | Coiled_coil; -; 0-unlimited; trigger=yes; |
Features
[?]
| From: GET1_YEAST (P53192) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 1 | Lumenal | |||||||||
| TRANSMEM | 2 | 21 | Helical | |||||||||
| TOPO_DOM | 22 | 104 | Cytoplasmic | |||||||||
| TRANSMEM | 105 | 125 | Helical | |||||||||
| TOPO_DOM | 126 | 181 | Lumenal | |||||||||
| TRANSMEM | 182 | 198 | Helical | |||||||||
| TOPO_DOM | 199 | Cter | Cytoplasmic | |||||||||
Additional information
[?]
| Size range | 170-237 amino acids |
| Related rules | None |
| Fusion | None |