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Annotation rule MF_03114
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General rule information [?]

Accession MF_03114
Dates 12-OCT-2009 (Created)
20-NOV-2019 (Last updated, Version 5)
Name Get2
Scope
Eukaryota; Saccharomycotina
Template P40056 (GET2_YEAST)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GET2
case <OC:Saccharomyces>
Protein name
RecName: Full=Golgi to ER traffic protein 2;
AltName: Full=Hydroxyurea resistance protein 2;
AltName: Full=Required for meiotic nuclear division protein 7;
else
Protein name
RecName: Full=Golgi to ER traffic protein 2;
end case
case <OC:Saccharomyces>
Gene name
GET2, HUR2, RMD7
else
Gene name
GET2
end case

Comments [?]

case <OC:Saccharomyces>
Function Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.
else
Function Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
end case
Subunit Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3).
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
Similarity Belongs to the GET2 family.

Keywords [?]

case <FTTag:glyco>
end case

Gene Ontology [?]

GO:0043529; Cellular component: GET complex.
GO:0045048; Biological process: protein insertion into ER membrane.

Cross-references [?]

Pfam PF08690; GET2; 1;

Features [?]

From: GET2_YEAST (P40056)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     148       Cytoplasmic        
TRANSMEM     149     169       Helical        
TOPO_DOM     170     196       Lumenal        
TRANSMEM     197     216       Helical        
TOPO_DOM     217     263       Cytoplasmic        
TRANSMEM     264     284       Helical        
TOPO_DOM     285     Cter       Lumenal        
case <OC:Saccharomyces>
CARBOHYD     173     173       N-linked (GlcNAc...) asparagine   glyco   N  
CARBOHYD     196     196       N-linked (GlcNAc...) asparagine   glyco   N  
end case

Additional information [?]

Size range 266-357 amino acids
Related rules None
Fusion None