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HAMAP rule MF_03114

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General rule information [?]

Accession MF_03114
Dates 12-OCT-2009 (Created)
26-FEB-2021 (Last updated, Version 6)
Name Get2
Scope(s) Eukaryota
Saccharomycotina
Template(s) P40056 (GET2_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03114 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GET2
case <OC:Saccharomyces>
Protein name RecName: Full=Golgi to ER traffic protein 2;
AltName: Full=Hydroxyurea resistance protein 2;
AltName: Full=Required for meiotic nuclear division protein 7;
else
Protein name RecName: Full=Golgi to ER traffic protein 2;
end case
case <OC:Saccharomyces>
Gene name Name=GET2; Synonyms=HUR2, RMD7;
else
Gene name Name=GET2;
end case

Comments [?]

case <OC:Saccharomyces>
FUNCTIONRequired for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function.
else
FUNCTIONRequired for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.
end case
SUBUNITComponent of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer.
SUBCELLULAR LOCATIONEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the GET2 family.

Keywords [?]


Gene Ontology [?]

GO:0043529; Cellular component:GET complex
GO:0045048; Biological process:protein insertion into ER membrane

Cross-references [?]

Pfam PF08690; GET2; 1;

Features [?]

From: GET2_YEAST (P40056)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 148 /note="Cytoplasmic"
TRANSMEM 149 169 /note="Helical"
TOPO_DOM 170 196 /note="Lumenal"
TRANSMEM 197 216 /note="Helical"
TOPO_DOM 217 263 /note="Cytoplasmic"
TRANSMEM 264 284 /note="Helical"
TOPO_DOM 285 Cter /note="Lumenal"
case <OC:Saccharomyces>
CARBOHYD 173 173 /note="N-linked (GlcNAc...) asparagine" glyco N
CARBOHYD 196 196 /note="N-linked (GlcNAc...) asparagine" glyco N
end case

Additional information [?]

Size range 266-357 amino acids
Related rules None
Fusion Nter: None Cter: None



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