HAMAP rule MF_03114
General rule information
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| Accession | MF_03114 |
| Dates | 12-OCT-2009 (Created) 26-FEB-2021 (Last updated, Version 6) |
| Name | Get2 |
| Scope | Eukaryota; Saccharomycotina |
| Template | P40056 (GET2_YEAST) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Saccharomyces>
| Protein name |
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else
| Protein name |
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end case
case <OC:Saccharomyces>
| Gene name |
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else
| Gene name |
|
end case
Comments
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case <OC:Saccharomyces>
| Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in DNA replication and DNA damage response and also in cell wall function. |
else
| Function | Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with @gn(GET1), acts as a membrane receptor for soluble @gn(GET3), which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor @gn(ERD2) to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. |
end case
| Subunit | Component of the Golgi to ER traffic (GET) complex, which is composed of @gn(GET1), @gn(GET2) and @gn(GET3). Within the complex, @gn(GET1) and @gn(GET2) form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the @gn(GET3) homodimer. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the GET2 family. |
Keywords
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Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
Membrane
Transmembrane
Transmembrane helix
Transport
ER-Golgi transport
Golgi apparatus
Membrane
Transmembrane
Transmembrane helix
Transport
case <FTTag:glyco>
end case
Gene Ontology
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GO:0043529; Cellular component: GET complex.
GO:0045048; Biological process: protein insertion into ER membrane.
GO:0045048; Biological process: protein insertion into ER membrane.
Cross-references
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| Pfam | PF08690; GET2; 1; |
Features
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| From: GET2_YEAST (P40056) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 148 | Cytoplasmic | |||||||||
| TRANSMEM | 149 | 169 | Helical | |||||||||
| TOPO_DOM | 170 | 196 | Lumenal | |||||||||
| TRANSMEM | 197 | 216 | Helical | |||||||||
| TOPO_DOM | 217 | 263 | Cytoplasmic | |||||||||
| TRANSMEM | 264 | 284 | Helical | |||||||||
| TOPO_DOM | 285 | Cter | Lumenal | |||||||||
case <OC:Saccharomyces>
| CARBOHYD | 173 | 173 | N-linked (GlcNAc...) asparagine | glyco | N | |||||||
| CARBOHYD | 196 | 196 | N-linked (GlcNAc...) asparagine | glyco | N |
end case
Additional information
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| Size range | 266-357 amino acids |
| Related rules | None |
| Fusion | None |