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HAMAP rule MF_03116

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General rule information [?]

Accession MF_03116
Dates 1-APR-2010 (Created)
24-MAY-2024 (Last updated, Version 16)
Name Salvage_MtnB_euk
Scope(s) Eukaryota
Template(s) Q96GX9 (MTNB_HUMAN); P47095 (MTNB_YEAST); [ Recover all ]
Triggered by HAMAP; MF_03116 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTNB
case <OC:Mammalia>
Protein name RecName: Full=Methylthioribulose-1-phosphate dehydratase;
                 Short=MTRu-1-P dehydratase;
                 EC=4.2.1.109;
AltName: Full=APAF1-interacting protein;
else case <OC:Vertebrata>
Protein name RecName: Full=Methylthioribulose-1-phosphate dehydratase;
                 Short=MTRu-1-P dehydratase;
                 EC=4.2.1.109;
AltName: Full=APAF1-interacting protein homolog;
else case <OC:Fungi>
Protein name RecName: Full=Methylthioribulose-1-phosphate dehydratase;
                 Short=MTRu-1-P dehydratase;
                 EC=4.2.1.109;
else
Protein name RecName: Full=Probable methylthioribulose-1-phosphate dehydratase;
                 Short=MTRu-1-P dehydratase;
                 EC=4.2.1.109;
end case
case <OC:Vertebrata>
Gene name Name=APIP;
else case <OC:Fungi>
Gene name Name=MDE1;
end case

Comments [?]

case <OC:Mammalia>
FUNCTIONCatalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
else case <OC:Vertebrata>
FUNCTIONCatalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
else
FUNCTIONCatalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
end case
CATALYTIC ACTIVITY Reaction=S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3- dioxopentyl phosphate + H2O; Xref=Rhea:RHEA:15549, ChEBI:CHEBI:15377, ChEBI:CHEBI:58548, ChEBI:CHEBI:58828; EC=4.2.1.109;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
PATHWAYAmino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.
case <OC:Mammalia>
SUBUNITHomotetramer. Interacts with APAF1. May interact with CASP1.
end case
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the aldolase class II family. MtnB subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding
GO:0046570; Molecular function:methylthioribulose 1-phosphate dehydratase activity
GO:0019509; Biological process:L-methionine salvage from methylthioadenosine

Cross-references [?]

Pfam PF00596; Aldolase_II; 1;
NCBIfam TIGR03328; salvage_mtnB; 1;

Features [?]

From: MTNB_HUMAN (Q96GX9)
Key From To Description Tag Condition FTGroup
ACT_SITE 139 139 /note="Proton donor/acceptor" E
BINDING 115 115 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 117 117 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 195 195 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
H
BINDING 97 97 /ligand="substrate" C

Additional information [?]

Size range 169-279 amino acids
Related rules MF_03118
Fusion Nter: None Cter: None



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