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Annotation rule MF_03116
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General rule information [?]

Accession MF_03116
Dates 1-APR-2010 (Created)
6-MAY-2020 (Last updated, Version 12)
Name Salvage_MtnB_euk
Scope
Eukaryota
Templates Q96GX9 (MTNB_HUMAN); P47095 (MTNB_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MTNB
case <OC:Mammalia>
Protein name
RecName: Full=Methylthioribulose-1-phosphate dehydratase;
Short=MTRu-1-P dehydratase;
EC 4.2.1.109;
AltName: Full=APAF1-interacting protein;
else case <OC:Vertebrata>
Protein name
RecName: Full=Methylthioribulose-1-phosphate dehydratase;
Short=MTRu-1-P dehydratase;
EC 4.2.1.109;
AltName: Full=APAF1-interacting protein homolog;
else case <OC:Fungi>
Protein name
RecName: Full=Methylthioribulose-1-phosphate dehydratase;
Short=MTRu-1-P dehydratase;
EC 4.2.1.109;
else
Protein name
RecName: Full=Probable methylthioribulose-1-phosphate dehydratase;
Short=MTRu-1-P dehydratase;
EC 4.2.1.109;
end case
case <OC:Vertebrata>
Gene name
APIP
else case <OC:Fungi>
Gene name
MDE1
end case

Comments [?]

case <OC:Mammalia>
Function Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
else case <OC:Vertebrata>
Function Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.
else
Function Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
end case
Catalytic activity RHEA:15549: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
EC 4.2.1.109
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.
case <OC:Mammalia>
Subunit Homotetramer. Interacts with APAF1. May interact with CASP1.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the aldolase class II family. MtnB subfamily.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Lyase
Metal-binding
Methionine biosynthesis
Zinc
case <OC:Vertebrata>
Apoptosis
end case

Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0046570; Molecular function: methylthioribulose 1-phosphate dehydratase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.

Cross-references [?]

Pfam PF00596; Aldolase_II; 1;
TIGRFAMs TIGR03328; salvage_mtnB; 1;

Features [?]

From: MTNB_HUMAN (Q96GX9)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     139     139       Proton donor/acceptor     E  
METAL     115     115       Zinc; via tele nitrogen     H  
METAL     117     117       Zinc; via tele nitrogen     H  
METAL     195     195       Zinc; via tele nitrogen     H  
BINDING     97     97       Substrate     C  

Additional information [?]

Size range 169-279 amino acids
Related rules MF_03118 (MTBC supersedes the current rule)
Fusion None


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