HAMAP rule MF_03116
General rule information
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| Accession | MF_03116 |
| Dates | 1-APR-2010 (Created)
1-JUN-2023 (Last updated, Version 15) |
| Name | Salvage_MtnB_euk |
| Scope(s) |
Eukaryota |
| Template(s) | Q96GX9 (MTNB_HUMAN); P47095 (MTNB_YEAST); [ Recover all ] |
| Triggered by |
HAMAP; MF_03116 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTNB |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=Methylthioribulose-1-phosphate dehydratase; Short=MTRu-1-P dehydratase; EC=4.2.1.109; AltName: Full=APAF1-interacting protein; |
| else case <OC:Vertebrata> | |
| Protein name | RecName: Full=Methylthioribulose-1-phosphate dehydratase; Short=MTRu-1-P dehydratase; EC=4.2.1.109; AltName: Full=APAF1-interacting protein homolog; |
| else case <OC:Fungi> | |
| Protein name | RecName: Full=Methylthioribulose-1-phosphate dehydratase; Short=MTRu-1-P dehydratase; EC=4.2.1.109; |
| else | |
| Protein name | RecName: Full=Probable methylthioribulose-1-phosphate dehydratase; Short=MTRu-1-P dehydratase; EC=4.2.1.109; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=APIP; |
| else case <OC:Fungi> | |
| Gene name | Name=MDE1; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. |
| else case <OC:Vertebrata> | |
| FUNCTION | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. |
| else | |
| FUNCTION | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3- dioxopentyl phosphate + H2O; Xref=Rhea:RHEA:15549, ChEBI:CHEBI:15377, ChEBI:CHEBI:58548, ChEBI:CHEBI:58828; EC=4.2.1.109; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| PATHWAY | Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. |
| case <OC:Mammalia> | |
| SUBUNIT | Homotetramer. Interacts with APAF1. May interact with CASP1. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the aldolase class II family. MtnB subfamily. |
Keywords
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| Amino-acid biosynthesis | |
| Cytoplasm | |
| Lyase | |
| Metal-binding | |
| Methionine biosynthesis | |
| Zinc | |
| case <OC:Vertebrata> | |
| Apoptosis | |
| end case | |
Gene Ontology
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| GO:0008270; Molecular function:zinc ion binding |
| GO:0046570; Molecular function:methylthioribulose 1-phosphate dehydratase activity |
| GO:0019284; Biological process:L-methionine salvage from S-adenosylmethionine |
Cross-references
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Features
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| From: MTNB_HUMAN (Q96GX9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 139 | 139 | /note="Proton donor/acceptor" | E | ||||||||
| BINDING | 115 | 115 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 117 | 117 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 195 | 195 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 97 | 97 | /ligand="substrate" | C | ||||||||
Additional information
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| Size range | 169-279 amino acids |
| Related rules |
MF_03118 |
| Fusion | Nter: None Cter: None |