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Annotation rule MF_03116 |
General rule information
[?]
Accession |
MF_03116 |
Dates |
1-APR-2010 (Created) 6-MAY-2020 (Last updated, Version 12) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Mammalia>
Protein name |
RecName:
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Full=Methylthioribulose-1-phosphate dehydratase;
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Short=MTRu-1-P dehydratase;
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EC 4.2.1.109;
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AltName:
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Full=APAF1-interacting protein;
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else case <OC:Vertebrata>
Protein name |
RecName:
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Full=Methylthioribulose-1-phosphate dehydratase;
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Short=MTRu-1-P dehydratase;
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EC 4.2.1.109;
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AltName:
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Full=APAF1-interacting protein homolog;
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else case <OC:Fungi>
Protein name |
RecName:
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Full=Methylthioribulose-1-phosphate dehydratase;
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Short=MTRu-1-P dehydratase;
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EC 4.2.1.109;
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else
Protein name |
RecName:
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Full=Probable methylthioribulose-1-phosphate dehydratase;
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Short=MTRu-1-P dehydratase;
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EC 4.2.1.109;
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end case
case <OC:Vertebrata>
else case <OC:Fungi>
end case
case <OC:Mammalia>
Function |
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. |
else case <OC:Vertebrata>
Function |
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis. |
else
Function |
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). |
end case
Catalytic activity |
RHEA:15549: S-methyl-5-thio-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O
EC 4.2.1.109
|
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway |
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. |
case <OC:Mammalia>
Subunit |
Homotetramer. Interacts with APAF1. May interact with CASP1. |
end case
Subcellular location |
Cytoplasm. |
Similarity |
Belongs to the aldolase class II family. MtnB subfamily. |
case <OC:Vertebrata>
end case
GO:0008270; Molecular function: zinc ion binding.
GO:0046570; Molecular function: methylthioribulose 1-phosphate dehydratase activity.
GO:0019284; Biological process: L-methionine salvage from S-adenosylmethionine.
From: MTNB_HUMAN (Q96GX9) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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ACT_SITE
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139
|
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139
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Proton donor/acceptor
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|
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E
|
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METAL
|
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115
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115
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Zinc; via tele nitrogen
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|
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H
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METAL
|
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117
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117
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Zinc; via tele nitrogen
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H
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METAL
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195
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195
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Zinc; via tele nitrogen
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H
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BINDING
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97
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97
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Substrate
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C
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Additional information
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Size range |
169-279 amino acids |
Related rules |
MF_03118 (MTBC supersedes the current rule) |
Fusion |
None |