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Annotation rule MF_03121
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General rule information [?]

Accession MF_03121
Dates 18-JUN-2010 (Created)
20-NOV-2019 (Last updated, Version 7)
Name lonp2_euk
Scope
Eukaryota
Templates Q86WA8 (LONP2_HUMAN); O64948 (LONP2_ARATH); Q2V573 (LONP2_PICAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LONP2
case <OC:Mammalia>
Protein name
RecName: Full=Lon protease homolog 2, peroxisomal;
EC 3.4.21.-;
AltName: Full=Lon protease-like protein 2;
Short=Lon protease 2;
AltName: Full=Peroxisomal Lon protease;
else
Protein name
RecName: Full=Lon protease homolog 2, peroxisomal;
EC 3.4.21.-;
end case
case <OC:Vertebrata>
Gene name
LONP2
end case

Comments [?]

case <OC:Mammalia>
Function ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.
Subunit Interacts with PEX5. Interacts with TYSND1.
else
Function ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.
end case
Subcellular location Peroxisome matrix.
Similarity Belongs to the peptidase S16 family.

Keywords [?]

case <FTTag:ATP>
ATP-binding
Nucleotide-binding
end case
Hydrolase
Peroxisome
Protease
Serine protease

Gene Ontology [?]

GO:0005782; Cellular component: peroxisomal matrix.
GO:0005524; Molecular function: ATP binding.
GO:0016887; Molecular function: ATPase activity.
GO:0004176; Molecular function: ATP-dependent peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.
GO:0006515; Biological process: protein quality control for misfolded or incompletely synthesized proteins.
GO:0016485; Biological process: protein processing.
GO:0016558; Biological process: protein import into peroxisome matrix.

Cross-references [?]

PROSITE PS51787; LON_N; 1; trigger=PRU01123;
PS51786; LON_PROTEOLYTIC; 1; trigger=PRU01122;
PS01046; LON_SER; 1;
Pfam PF00004; AAA; 1;
PF02190; LON; 1;
PRINTS PR00830; ENDOLAPTASE; 1;
TIGRFAMs TIGR00763; lon; 1;

Features [?]

From: LONP2_HUMAN (Q86WA8)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     375     382       ATP   ATP   G-P-[PT]-G-[ITV]-G-K-T  
ACT_SITE     743     743             S  
ACT_SITE     786     786             K  
MOTIF     Cter-2     Cter       Microbody targeting signal        

Additional information [?]

Size range 773-1258 amino acids
Related rules MF_03120 (LONM); MF_01973 (LON)
Fusion None


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