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Annotation rule MF_03121 |
Accession | MF_03121 |
Dates | 18-JUN-2010 (Created) 20-NOV-2019 (Last updated, Version 7) |
Name | lonp2_euk |
Scope | Eukaryota |
Templates | Q86WA8 (LONP2_HUMAN); O64948 (LONP2_ARATH); Q2V573 (LONP2_PICAN): [Recover all] |
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Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. |
Subunit | Interacts with PEX5. Interacts with TYSND1. |
Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. |
Subcellular location | Peroxisome matrix. |
Similarity | Belongs to the peptidase S16 family. |
PROSITE | PS51787; LON_N; 1; trigger=PRU01123; |
PS51786; LON_PROTEOLYTIC; 1; trigger=PRU01122; | |
PS01046; LON_SER; 1; | |
Pfam | PF00004; AAA; 1; |
PF02190; LON; 1; | |
PRINTS | PR00830; ENDOLAPTASE; 1; |
TIGRFAMs | TIGR00763; lon; 1; |
From: LONP2_HUMAN (Q86WA8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
NP_BIND | 375 | 382 | ATP | ATP | G-P-[PT]-G-[ITV]-G-K-T | |||||||
ACT_SITE | 743 | 743 | S | |||||||||
ACT_SITE | 786 | 786 | K | |||||||||
MOTIF | Cter-2 | Cter | Microbody targeting signal |