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| Annotation rule MF_03131 |
General rule information
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| Accession | MF_03131 |
| Dates | 22-OCT-2010 (Created) 20-NOV-2019 (Last updated, Version 8) |
| Name | Acetate_kinase_euk |
| Scope | Eukaryota |
| Template | P0A6A3 (ACKA_ECOLI) |
case <OC:Eukaryota>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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Comments
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| Catalytic activity | RHEA:11352: acetate + ATP = acetyl phosphate + ADP
EC 2.7.2.1 |
| Cofactor | Mg(2+) |
| Pathway | Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. |
| Similarity | Belongs to the acetokinase family. |
Keywords
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Gene Ontology
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GO:0008776; Molecular function: acetate kinase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016310; Biological process: phosphorylation.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016310; Biological process: phosphorylation.
Cross-references
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| Pfam | PF00871; Acetate_kinase; 1; |
| PIRSF | PIRSF000722; Acetate_prop_kin; 1; |
| PRINTS | PR00471; ACETATEKNASE; 1; |
| TIGRFAMs | TIGR00016; ackA; 1; |
| PROSITE | PS01075; ACETATE_KINASE_1; 1; |
| PS01076; ACETATE_KINASE_2; 1; |
Features
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| From: ACKA_METTE (P38502) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND (Optional) | 208 | 212 | ATP | H-x-G-x-G | ||||||||
| NP_BIND (Optional) | 283 | 285 | ATP | D-x-R | ||||||||
| NP_BIND (Optional) | 331 | 335 | ATP | G-[IVLM]-G-E-[NH] | ||||||||
| ACT_SITE | 148 | 148 | Proton donor/acceptor | D | ||||||||
| METAL | 7 | 7 | Magnesium | N | ||||||||
| METAL | 384 | 384 | Magnesium | E | ||||||||
| BINDING (Optional) | 14 | 14 | ATP | K | ||||||||
| BINDING (Optional) | 91 | 91 | Substrate | R | ||||||||
| SITE | 180 | 180 | Transition state stabilizer | H | ||||||||
| SITE | 241 | 241 | Transition state stabilizer | R | ||||||||
Additional information
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| Size range | 392-488 amino acids |
| Related rules | MF_00542 (BUK); MF_01881 (TDCD supersedes the current rule); MF_01882 (PDUW supersedes the current rule) |
| Fusion | None |