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HAMAP rule MF_03131

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General rule information [?]

Accession MF_03131
Dates 22-OCT-2010 (Created)
24-MAY-2024 (Last updated, Version 12)
Name Acetate_kinase_euk
Scope(s) Eukaryota
Template(s) P0A6A3 (ACKA_ECOLI); [ Recover all ]
Triggered by
case c? <OC:Eukaryota>
HAMAP; MF_00020 (Get profile general information and statistics)
end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACKA
Protein name RecName: Full=Probable acetate kinase;
                 EC=2.7.2.1;
AltName: Full=Acetokinase;

Comments [?]

CATALYTIC ACTIVITY Reaction=acetate + ATP = acetyl phosphate + ADP; Xref=Rhea:RHEA:11352, ChEBI:CHEBI:22191, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.2.1;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
PATHWAYMetabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.
SIMILARITYBelongs to the acetokinase family.

Keywords [?]


Gene Ontology [?]

GO:0008776; Molecular function:acetate kinase activity
GO:0000287; Molecular function:magnesium ion binding
GO:0006085; Biological process:acetyl-CoA biosynthetic process
GO:0016310; Biological process:phosphorylation

Cross-references [?]

Pfam PF00871; Acetate_kinase; 1;
PIRSF PIRSF000722; Acetate_prop_kin; 1;
PRINTS PR00471; ACETATEKNASE; 1;
NCBIfam TIGR00016; ackA; 1;
PROSITE PS01075; ACETATE_KINASE_1; 1;
PROSITE PS01076; ACETATE_KINASE_2; 1;

Features [?]

From: ACKA_METTE (P38502)
Key From To Description Tag Condition FTGroup
BINDING 208 212 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
H-x-G-x-G
BINDING 283 285 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
D-x-R
BINDING 331 335 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-[IVLM]-G-E-[NH]
ACT_SITE 148 148 /note="Proton donor/acceptor" D
BINDING 7 7 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
N
BINDING 384 384 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
E
BINDING 14 14 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
K
BINDING 91 91 /ligand="substrate" R
SITE 180 180 /note="Transition state stabilizer" H
SITE 241 241 /note="Transition state stabilizer" R

Additional information [?]

Size range 392-488 amino acids
Related rules MF_00542
MF_01881
MF_01882
Fusion Nter: None Cter: None



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