HAMAP rule MF_03131

General rule information [?]

Accession	MF_03131
Dates	22-OCT-2010 (Created) 1-JUN-2023 (Last updated, Version 11)

Name	Acetate_kinase_euk

Scope

Eukaryota

Template

P0A6A3 (ACKA_ECOLI)

case <OC:Eukaryota>

Triggered by

HAMAP; MF_00020 (Get profile general information and statistics)

end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ACKA

Protein name

RecName:		Full=Probable acetate kinase;
		EC 2.7.2.1;
AltName:		Full=Acetokinase;

Comments [?]

Catalytic activity	RHEA:11352: acetate + ATP = acetyl phosphate + ADP EC 2.7.2.1
Cofactor	Mg(2+)
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.
Similarity	Belongs to the acetokinase family.

Keywords [?]

ATP-binding
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0008776; Molecular function: acetate kinase activity.
GO:0000287; Molecular function: magnesium ion binding.
GO:0016310; Biological process: phosphorylation.

Cross-references [?]

Pfam	PF00871; Acetate_kinase; 1;
PIRSF	PIRSF000722; Acetate_prop_kin; 1;
PRINTS	PR00471; ACETATEKNASE; 1;
NCBIfam	TIGR00016; ackA; 1;
PROSITE	PS01075; ACETATE_KINASE_1; 1;
	PS01076; ACETATE_KINASE_2; 1;

Features [?]

From: ACKA_METTE (P38502)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 208 212 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 H-x-G-x-G

BINDING (Optional) 283 285 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 D-x-R

BINDING (Optional) 331 335 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 G-[IVLM]-G-E-[NH]

ACT_SITE 148 148 Proton donor/acceptor D

BINDING 7 7 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N

BINDING 384 384 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E

BINDING (Optional) 14 14 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 K

BINDING (Optional) 91 91 /ligand="substrate R

SITE 180 180 Transition state stabilizer H

SITE 241 241 Transition state stabilizer R

Additional information [?]

Size range	392-488 amino acids
Related rules	MF_00542 (BUK); MF_01881 (TDCD supersedes the current rule); MF_01882 (PDUW supersedes the current rule)
Fusion	None

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