HAMAP rule MF_03131
General rule information
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| Accession | MF_03131 |
| Dates | 22-OCT-2010 (Created)
24-MAY-2024 (Last updated, Version 12) |
| Name | Acetate_kinase_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P0A6A3 (ACKA_ECOLI); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_00020 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACKA |
| Protein name | RecName: Full=Probable acetate kinase; EC=2.7.2.1; AltName: Full=Acetokinase; |
Comments
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| CATALYTIC ACTIVITY | Reaction=acetate + ATP = acetyl phosphate + ADP; Xref=Rhea:RHEA:11352, ChEBI:CHEBI:22191, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216; EC=2.7.2.1; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. |
| SIMILARITY | Belongs to the acetokinase family. |
Keywords
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Gene Ontology
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| GO:0008776; Molecular function:acetate kinase activity |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0006085; Biological process:acetyl-CoA biosynthetic process |
| GO:0016310; Biological process:phosphorylation |
Cross-references
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| Pfam | PF00871; Acetate_kinase; 1; |
| PIRSF | PIRSF000722; Acetate_prop_kin; 1; |
| PRINTS | PR00471; ACETATEKNASE; 1; |
| NCBIfam | TIGR00016; ackA; 1; |
| PROSITE | PS01075; ACETATE_KINASE_1; 1; |
| PROSITE | PS01076; ACETATE_KINASE_2; 1; |
Features
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| From: ACKA_METTE (P38502) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 208 | 212 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
H-x-G-x-G | ||||||||
| BINDING | 283 | 285 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
D-x-R | ||||||||
| BINDING | 331 | 335 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G-[IVLM]-G-E-[NH] | ||||||||
| ACT_SITE | 148 | 148 | /note="Proton donor/acceptor" | D | ||||||||
| BINDING | 7 | 7 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
| BINDING | 384 | 384 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | ||||||||
| BINDING | 14 | 14 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
K | ||||||||
| BINDING | 91 | 91 | /ligand="substrate" | R | ||||||||
| SITE | 180 | 180 | /note="Transition state stabilizer" | H | ||||||||
| SITE | 241 | 241 | /note="Transition state stabilizer" | R | ||||||||
Additional information
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| Size range | 392-488 amino acids |
| Related rules |
MF_00542 MF_01881 MF_01882 |
| Fusion | Nter: None Cter: None |