 |
|
Annotation rule MF_03137 |
General rule information
[?]
Accession |
MF_03137 |
Dates |
2-NOV-2010 (Created) 20-NOV-2019 (Last updated, Version 8) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Vertebrata> or <OC:Fungi>
Protein name |
RecName:
|
Full=Translation factor , mitochondrial;
|
|
EC 3.6.5.n1;
|
AltName:
|
Full=Elongation factor 4 homolog;
|
|
Short=EF-4;
|
AltName:
|
Full=GTPase ;
|
AltName:
|
Full=Ribosomal back-translocase;
|
|
else case <OC:Drosophilidae>
Protein name |
RecName:
|
Full=Translation factor waclaw, mitochondrial;
|
|
EC 3.6.5.n1;
|
AltName:
|
Full=Elongation factor 4 homolog;
|
|
Short=EF-4;
|
AltName:
|
Full=GTPase GUF1 homolog;
|
AltName:
|
Full=Ribosomal back-translocase;
|
|
else
Protein name |
RecName:
|
Full=Translation factor GUF1 homolog, mitochondrial;
|
|
EC 3.6.5.n1;
|
AltName:
|
Full=Elongation factor 4 homolog;
|
|
Short=EF-4;
|
AltName:
|
Full=GTPase GUF1 homolog;
|
AltName:
|
Full=Ribosomal back-translocase;
|
|
end case
case <OC:Vertebrata> or <OC:Fungi>
else case <OC:Drosophilidae>
end case
Function |
Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. |
Catalytic activity |
RHEA:19669: GTP + H2O = GDP + H(+) + phosphate
EC 3.6.5.n1
|
Subcellular location |
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the GTP-binding elongation factor family. LepA subfamily. |
GO:0005759; Cellular component: mitochondrial matrix.
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0043022; Molecular function: ribosome binding.
GO:0045727; Biological process: positive regulation of translation.
General |
TransitM; -; 0-1; trigger=yes; |
From: GUF1_YEAST (P46943) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
NP_BIND
|
|
53
|
|
60
|
|
GTP
|
|
|
|
[AS]-H-[IV]-D-[HS]-G-K-[ST]
|
|
|
NP_BIND
|
|
120
|
|
124
|
|
GTP
|
|
|
|
D-T-[CP]-G-H
|
|
|
NP_BIND
|
|
174
|
|
177
|
|
GTP
|
|
|
|
[NT]-K-[IMV]-D
|
|
|
Additional information
[?]
Size range |
627-1085 amino acids |
Related rules |
MF_03138 (GUFP supersedes the current rule) |
Fusion |
None |