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Annotation rule MF_03137
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General rule information [?]

Accession MF_03137
Dates 2-NOV-2010 (Created)
20-NOV-2019 (Last updated, Version 8)
Name GUF1
Scope
Eukaryota
Templates P46943 (GUF1_YEAST); Q8N442 (GUF1_HUMAN): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GUF1
case <OC:Vertebrata> or <OC:Fungi>
Protein name
RecName: Full=Translation factor , mitochondrial;
EC 3.6.5.n1;
AltName: Full=Elongation factor 4 homolog;
Short=EF-4;
AltName: Full=GTPase ;
AltName: Full=Ribosomal back-translocase;
else case <OC:Drosophilidae>
Protein name
RecName: Full=Translation factor waclaw, mitochondrial;
EC 3.6.5.n1;
AltName: Full=Elongation factor 4 homolog;
Short=EF-4;
AltName: Full=GTPase GUF1 homolog;
AltName: Full=Ribosomal back-translocase;
else
Protein name
RecName: Full=Translation factor GUF1 homolog, mitochondrial;
EC 3.6.5.n1;
AltName: Full=Elongation factor 4 homolog;
Short=EF-4;
AltName: Full=GTPase GUF1 homolog;
AltName: Full=Ribosomal back-translocase;
end case
case <OC:Vertebrata> or <OC:Fungi>
Gene name
GUF1
else case <OC:Drosophilidae>
Gene name
waw
end case

Comments [?]

Function Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.
Catalytic activity RHEA:19669: GTP + H2O = GDP + H(+) + phosphate
EC 3.6.5.n1
Subcellular location Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the GTP-binding elongation factor family. LepA subfamily.

Keywords [?]

GTP-binding
Hydrolase
Membrane
Mitochondrion
Mitochondrion inner membrane
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0005759; Cellular component: mitochondrial matrix.
GO:0005525; Molecular function: GTP binding.
GO:0003924; Molecular function: GTPase activity.
GO:0043022; Molecular function: ribosome binding.
GO:0045727; Biological process: positive regulation of translation.

Cross-references [?]

Pfam PF00679; EFG_C; 1;
PF00009; GTP_EFTU; 1;
PF03144; GTP_EFTU_D2; 1;
PF06421; LepA_C; 1;
PRINTS PR00315; ELONGATNFCT; 1;
TIGRFAMs TIGR01393; lepA; 1;
TIGR00231; Small_GTP; 1;
PROSITE PS00301; G_TR_1; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: GUF1_YEAST (P46943)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     53     60       GTP     [AS]-H-[IV]-D-[HS]-G-K-[ST]  
NP_BIND     120     124       GTP     D-T-[CP]-G-H  
NP_BIND     174     177       GTP     [NT]-K-[IMV]-D  

Additional information [?]

Size range 627-1085 amino acids
Related rules MF_03138 (GUFP supersedes the current rule)
Fusion None


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