HAMAP rule MF_03141
General rule information
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| Accession | MF_03141 |
| Dates | 22-DEC-2010 (Created)
20-NOV-2019 (Last updated, Version 12) |
| Name | lis1 |
| Scope(s) |
Eukaryota |
| Template(s) | P43034 (LIS1_HUMAN); Q00664 (LIS1_EMENI); [ Recover all ] |
| Triggered by |
HAMAP; MF_03141 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LIS1 |
| case <OC:Mammalia> | |
| Protein name | RecName: Full=Platelet-activating factor acetylhydrolase IB subunit alpha; AltName: Full=Lissencephaly-1 protein; Short=LIS-1; AltName: Full=PAF acetylhydrolase 45 kDa subunit; Short=PAF-AH 45 kDa subunit; AltName: Full=PAF-AH alpha; Short=PAFAH alpha; |
| else case <OC:Eurotiales> | |
| Protein name | RecName: Full=Nuclear distribution protein nudF; AltName: Full=Lissencephaly-1 homolog; Short=LIS-1; |
| else case <OC:Fungi> and not <OC:Eurotiales> | |
| Protein name | RecName: Full=Nuclear distribution protein PAC1; AltName: Full=Lissencephaly-1 homolog; Short=LIS-1; AltName: Full=nudF homolog; |
| else | |
| Protein name | RecName: Full=Lissencephaly-1 homolog; |
| end case | |
| case <OC:Vertebrata> | |
| Gene name | Name=PAFAH1B1; Synonyms=LIS1; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=Lis-1; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=lis-1; |
| else case <OC:Eurotiales> | |
| Gene name | Name=nudF; Synonyms=lis1; |
| else case <OC:Fungi> and not <OC:Eurotiales> | |
| Gene name | Name=PAC1; Synonyms=LIS1; |
| end case | |
Comments
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| case <OC:Mammalia> | |
| FUNCTION | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position. |
| else case <OC:Vertebrata> and not <OC:Mammalia> | |
| FUNCTION | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. |
| else case <OC:Saccharomycotina> or <OC:Cryptococcaceae> | |
| FUNCTION | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein- mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck. |
| else case <OC:Fungi> and not (<OC:Saccharomycotina> or <OC:Cryptococcaceae>) | |
| FUNCTION | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs. |
| else | |
| FUNCTION | Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. |
| end case | |
| case <OC:Mammalia> | |
| SUBUNIT | Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. |
| else case <OC:Vertebrata> | |
| SUBUNIT | Can self-associate. Interacts with dynein, dynactin, @gn(NDE1) and @gn(NDEL1). |
| else case <OC:Eurotiales> | |
| SUBUNIT | Self-associates. Interacts with nudE and dynein. |
| else case <OC:Fungi> and not <OC:Eurotiales> | |
| SUBUNIT | Self-associates. Interacts with @gn(NDL1) and dynein. |
| else case <OC:Nematoda> | |
| SUBUNIT | May be a component of a dynein regulatory complex composed of at least lis-1 and nud-2. Interacts with nud-2. |
| end case | |
| case <OC:Mammalia> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus membrane. Note=Localizes to the plus end of microtubules and to the centrosome. May localize to the nuclear membrane. Redistributes to axons during neuronal development. Also localizes to the microtubules of the manchette in elongating spermatids and to the meiotic spindle in spermatocytes. |
| else case <OC:Saccharomycotina> or <OC:Cryptococcaceae> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules and the mitotic spindle poles. |
| else case <OC:Fungi> and not (<OC:Saccharomycotina> or <OC:Cryptococcaceae>) | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles. |
| else case not <OC:Fungi> | |
| SUBCELLULAR LOCATION | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the plus end of microtubules and to the centrosome. |
| end case | |
| case <Feature:PS50896> | |
| DOMAIN | Dimerization mediated by the LisH domain may be required to activate dynein. |
| end case | |
| SIMILARITY | Belongs to the WD repeat LIS1/nudF family. |
Keywords
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| Cell cycle | |
| Cell division | |
| Coiled coil | |
| Cytoplasm | |
| Cytoskeleton | |
| Microtubule | |
| Mitosis | |
| Transport | |
| case <OC:Vertebrata> | |
| Developmental protein | |
| Differentiation | |
| Neurogenesis | |
| end case | |
| case <OC:Mammalia> | |
| Lipid degradation | |
| Lipid metabolism | |
| Membrane | |
| Nucleus | |
| end case | |
Gene Ontology
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| GO:0005737; Cellular component:cytoplasm | |
| GO:0005875; Cellular component:microtubule associated complex | |
| GO:0070840; Molecular function:dynein complex binding | |
| GO:0051012; Biological process:microtubule sliding | |
| GO:0000132; Biological process:establishment of mitotic spindle orientation | |
| GO:0007017; Biological process:microtubule-based process | |
| case <OCellular component:Vertebrata> | |
| GO:0007399; Biological process:nervous system development | |
| end case | |
Cross-references
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| PROSITE | PS50896; LISH; 0-1; |
| PROSITE | PS00678; WD_REPEATS_1; 1-6; |
| PROSITE | PS50082; WD_REPEATS_2; 1-8; |
| PROSITE | PS50294; WD_REPEATS_REGION; 1; |
| Pfam | PF08513; LisH; 1; |
| Pfam | PF00400; WD40; 7; |
| PRINTS | PR00320; GPROTEINBRPT; 1; |
| PIRSF | PIRSF037647; Dynein_regulator_Lis1; 1; |
| General | Coiled_coil; -; 1-unlimited; |
| REP | Repeat_WD40; WD40; 7-8; |
Features
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| From: LIS1_HUMAN (P43034) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Vertebrata> | ||||||||||||
| INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
| end case | ||||||||||||
| case <OC:Mammalia> | ||||||||||||
| REGION | Nter | 102 | /note="Interaction with NDEL1" | |||||||||
| REGION | Nter | 66 | /note="Interaction with NDE1" | |||||||||
| REGION | Nter | 38 | /note="Required for self-association and interaction with PAFAH1B2 and PAFAH1B3" | |||||||||
| REGION | 83 | Cter | /note="Interaction with dynein and dynactin" | |||||||||
| REGION | 367 | 409 | /note="Interaction with DCX" | |||||||||
| REGION | 388 | Cter | /note="Interaction with NDEL1" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 390-529 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |