HAMAP rule MF_03146
General rule information
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Accession | MF_03146 |
Dates | 13-MAY-2011 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | TSR3_euk |
Scope | Eukaryota |
Templates | Q12094 (TSR3_YEAST); Q9UJK0 (TSR3_HUMAN): [Recover all] |
case <OC:Eukaryota>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Fungi>
Gene name |
|
end case
Comments
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case <OC:Vertebrata>
Function | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. |
Catalytic activity | RHEA:63292: N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63293) |
else case <OC:Fungi>
Function | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. |
Catalytic activity | RHEA:63300: N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63301) |
else
Function | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi). |
Catalytic activity | RHEA:63296: an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63297) |
end case
case <OC:Vertebrata>
Subcellular location | Cytoplasm. |
else case <OC:Fungi>
Subcellular location | Cytoplasm. Nucleus. |
end case
Similarity | Belongs to the TDD superfamily. TSR3 family. |
Keywords
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case <OC:Vertebrata> or <OC:Fungi>
end case
case <OC:Fungi>
end case
Gene Ontology
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case <OC:Vertebrata> or <OC:Fungi>
GO:0005737; Cellular component: cytoplasm.
end case
case <OC:Fungi>
GO:0005634; Cellular component: nucleus.
end case
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
GO:0006364; Biological process: rRNA processing.
GO:0000455; Biological process: enzyme-directed rRNA pseudouridine synthesis.
GO:0006364; Biological process: rRNA processing.
GO:0000455; Biological process: enzyme-directed rRNA pseudouridine synthesis.
Cross-references
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Features
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From: TSR3_YEAST (Q12094) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 62 | 62 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [ST] | ||||||||
BINDING | 110 | 110 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [VIL] | ||||||||
BINDING | 133 | 133 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [LI] | ||||||||
BINDING | 148 | 148 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [WY] |
Additional information
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Size range | 247-421 amino acids |
Related rules | None |
Fusion | None |