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HAMAP rule MF_03146

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General rule information [?]

Accession MF_03146
Dates 13-MAY-2011 (Created)
19-NOV-2022 (Last updated, Version 10)
Name TSR3_euk
Scope
Eukaryota
Templates Q12094 (TSR3_YEAST); Q9UJK0 (TSR3_HUMAN): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TSR3
Protein name
RecName: Full=18S rRNA aminocarboxypropyltransferase;
EC 2.5.1.-;
case <OC:Fungi>
Gene name
TSR3
end case

Comments [?]

case <OC:Vertebrata>
Function Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
Catalytic activity RHEA:63292: N(1)-methylpseudouridine(1248) in human 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1248) in human 18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63293)
else case <OC:Fungi>
Function Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
Catalytic activity RHEA:63300: N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63301)
else
Function Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
Catalytic activity RHEA:63296: an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3-carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'-thioadenosine
PhysiologicalDirection=left-to-right (RHEA:63297)
end case
case <OC:Vertebrata>
Subcellular location Cytoplasm.
else case <OC:Fungi>
Subcellular location Cytoplasm. Nucleus.
end case
Similarity Belongs to the TDD superfamily. TSR3 family.

Keywords [?]

case <OC:Vertebrata> or <OC:Fungi>
Cytoplasm
end case
case <OC:Fungi>
Nucleus
end case
Ribosome biogenesis
S-adenosyl-L-methionine
Transferase
rRNA processing

Gene Ontology [?]

case <OC:Vertebrata> or <OC:Fungi>
GO:0005737; Cellular component: cytoplasm.
end case
case <OC:Fungi>
GO:0005634; Cellular component: nucleus.
end case
GO:1904047; Molecular function: S-adenosyl-L-methionine binding.
GO:0006364; Biological process: rRNA processing.
GO:0000455; Biological process: enzyme-directed rRNA pseudouridine synthesis.

Cross-references [?]

Pfam PF04034; Ribo_biogen_C; 1;
PF04068; RLI; 1;

Features [?]

From: TSR3_YEAST (Q12094)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     62     62       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [ST]  
BINDING     110     110       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [VIL]  
BINDING     133     133       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [LI]  
BINDING     148     148       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     [WY]  

Additional information [?]

Size range 247-421 amino acids
Related rules None
Fusion None


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