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HAMAP rule MF_03150

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General rule information [?]

Accession MF_03150
Dates 18-AUG-2011 (Created)
13-SEP-2022 (Last updated, Version 9)
Name GatA_euk
Scope
Eukaryota
Templates Q9H0R6 (GATA_HUMAN); Q9LI77 (GATA_ARATH): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GATA
case <OC:Viridiplantae>
Protein name
RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial;
Short=Glu-AdT subunit A;
EC 6.3.5.7;
else case <OC:Vertebrata>
Protein name
RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial;
Short=Glu-AdT subunit A;
EC 6.3.5.7;
AltName: Full=Glutaminyl-tRNA synthase-like protein 1;
else
Protein name
RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial;
Short=Glu-AdT subunit A;
EC 6.3.5.7;
end case
case <OC:Vertebrata>
Gene name
QRSL1
else case <OC:Saccharomycotina>
Gene name
HER2
else case <OC:Viridiplantae>
Gene name
GATA
else case <OC:Insecta>
Gene name
GatA
end case

Comments [?]

case <OC:Viridiplantae>
Function Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
else
Function Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
end case
Catalytic activity RHEA:17521: ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate
EC 6.3.5.7
case <OC:Vertebrata>
Subunit Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (@gn(QRSL1)), B (@gn(GATB)) and C (@gn(GATC)) subunits.
else case <OC:Saccharomycotina>
Subunit Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.
else
Subunit Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.
end case
case <OC:Viridiplantae>
Subcellular location Mitochondrion. Plastid, chloroplast stroma.
else
Subcellular location Mitochondrion.
end case
case <OC:Viridiplantae>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the amidase family. GatA subfamily.

Keywords [?]

case <OC:Viridiplantae>
Chloroplast
Plastid
end case
Mitochondrion
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

case <OC:Viridiplantae>
GO:0009507; Cellular component: chloroplast.
end case
GO:0005739; Cellular component: mitochondrion.
GO:0030956; Cellular component: glutamyl-tRNA(Gln) amidotransferase complex.
GO:0050567; Molecular function: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity.
GO:0016884; Molecular function: carbon-nitrogen ligase activity, with glutamine as amido-N-donor.
GO:0070681; Biological process: glutaminyl-tRNAGln biosynthesis via transamidation.
GO:0032543; Biological process: mitochondrial translation.

Cross-references [?]

PROSITE PS00571; AMIDASES; 1;
Pfam PF01425; Amidase; 1;
TIGRFAMs TIGR00132; GatA; 1;

Features [?]

From: GATA_HUMAN (Q9H0R6)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     76     76       Charge relay system     K  
ACT_SITE     171     171       Charge relay system     S  
ACT_SITE     195     195       Acyl-ester intermediate     S  

Additional information [?]

Size range 450-550 amino acids
Related rules None
Fusion None


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