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HAMAP rule MF_03153

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General rule information [?]

Accession MF_03153
Dates 24-OCT-2011 (Created)
10-DEC-2019 (Last updated, Version 9)
Name U1_C
Scope
Eukaryota
Templates P09234 (RU1C_HUMAN); Q05900 (RU1C_YEAST): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RU1C
Protein name
RecName: Full=U1 small nuclear ribonucleoprotein C;
Short=U1 snRNP C;
Short=U1-C;
Short=U1C;
case <OC:Vertebrata>
Gene name
SNRPC
else case <OC:Drosophilidae>
Gene name
snRNP-U1-C
else case <OC:Dictyostelia>
Gene name
snrpC
else case <OC:Saccharomycotina>
Gene name
YHC1
end case

Comments [?]

case <OC:Vertebrata> or <OC:Dictyostelia>
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subunit U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
else
Function Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Subunit U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
end case
Subcellular location Nucleus.
Similarity Belongs to the U1 small nuclear ribonucleoprotein C family.

Keywords [?]

Metal-binding
Nucleus
Ribonucleoprotein
RNA-binding
Zinc
Zinc-finger

Gene Ontology [?]

GO:0000243; Cellular component: commitment complex.
GO:0005685; Cellular component: U1 snRNP.
GO:0071004; Cellular component: U2-type prespliceosome.
GO:0003729; Molecular function: mRNA binding.
GO:0030619; Molecular function: U1 snRNA binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000395; Biological process: mRNA 5'-splice site recognition.
GO:0000387; Biological process: spliceosomal snRNP assembly.

Cross-references [?]

PROSITE PS50171; ZF_MATRIN; 1; trigger=PRU00130;
Pfam PF06220; zf-U1; 1;
PIRSF PIRSF037969; U1_snRNP-C; 1;

Additional information [?]

Size range 122-242 amino acids
Related rules None
Fusion None


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