HAMAP rule MF_03153
General rule information
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Accession | MF_03153 |
Dates | 24-OCT-2011 (Created) 10-DEC-2019 (Last updated, Version 9) |
Name | U1_C |
Scope | Eukaryota |
Templates | P09234 (RU1C_HUMAN); Q05900 (RU1C_YEAST): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
|
case <OC:Vertebrata>
Gene name |
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else case <OC:Drosophilidae>
Gene name |
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else case <OC:Dictyostelia>
Gene name |
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else case <OC:Saccharomycotina>
Gene name |
|
end case
Comments
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case <OC:Vertebrata> or <OC:Dictyostelia>
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
Subunit | U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. |
else
Function | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. |
Subunit | U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. |
end case
Subcellular location | Nucleus. |
Similarity | Belongs to the U1 small nuclear ribonucleoprotein C family. |
Keywords
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Gene Ontology
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GO:0000243; Cellular component: commitment complex.
GO:0005685; Cellular component: U1 snRNP.
GO:0071004; Cellular component: U2-type prespliceosome.
GO:0003729; Molecular function: mRNA binding.
GO:0030619; Molecular function: U1 snRNA binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000395; Biological process: mRNA 5'-splice site recognition.
GO:0000387; Biological process: spliceosomal snRNP assembly.
GO:0005685; Cellular component: U1 snRNP.
GO:0071004; Cellular component: U2-type prespliceosome.
GO:0003729; Molecular function: mRNA binding.
GO:0030619; Molecular function: U1 snRNA binding.
GO:0008270; Molecular function: zinc ion binding.
GO:0000395; Biological process: mRNA 5'-splice site recognition.
GO:0000387; Biological process: spliceosomal snRNP assembly.
Cross-references
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PROSITE | PS50171; ZF_MATRIN; 1; trigger=PRU00130; |
Pfam | PF06220; zf-U1; 1; |
PIRSF | PIRSF037969; U1_snRNP-C; 1; |
Additional information
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Size range | 122-242 amino acids |
Related rules | None |
Fusion | None |