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HAMAP rule MF_03153

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General rule information [?]

PURL https://purl.expasy.org/hamap/rule/MF_03153
Accession MF_03153
Dates 07-DEC-2012 (Created)
10-DEC-2019 (Last updated, Version 10)
Name U1_C
Scope(s) Eukaryota
Template(s) P09234; Q05900; [ Recover all ]
Triggered by HAMAP; MF_03153 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RU1C
Protein name RecName: Full=U1 small nuclear ribonucleoprotein C;
                 Short=U1 snRNP C;
                 Short=U1-C;
                 Short=U1C;
case <OC:Vertebrata>
Gene name Name=SNRPC;
else case <OC:Drosophilidae>
Gene name Name=snRNP-U1-C;
else case <OC:Dictyostelia>
Gene name Name=snrpC;
else case <OC:Saccharomycotina>
Gene name Name=YHC1;
end case

Comments [?]

case <OC:Vertebrata> or <OC:Dictyostelia>
FUNCTIONComponent of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
SUBUNITU1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
else
FUNCTIONComponent of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
SUBUNITU1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.
end case
SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the U1 small nuclear ribonucleoprotein C family.

Keywords [?]

Metal-binding
Nucleus
Ribonucleoprotein
RNA-binding
Zinc
Zinc-finger

Gene Ontology [?]

GO:0000243; Cellular component:commitment complex
GO:0005685; Cellular component:U1 snRNP
GO:0071004; Cellular component:U2-type prespliceosome
GO:0003729; Molecular function:mRNA binding
GO:0030619; Molecular function:U1 snRNA binding
GO:0008270; Molecular function:zinc ion binding
GO:0000395; Biological process:mRNA 5'-splice site recognition
GO:0000387; Biological process:spliceosomal snRNP assembly

Cross-references [?]

PROSITE PS50171; ZF_MATRIN; 1;
Pfam PF06220; zf-U1; 1;
PIRSF PIRSF037969; U1_snRNP-C; 1;

Features [?]


Additional information [?]

Size range 122-242 amino acids
Related rules None
Fusion Nter: None Cter: None



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