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Annotation rule MF_03159 |
General rule information
[?]
Accession |
MF_03159 |
Dates |
14-FEB-2012 (Created) 26-MAY-2020 (Last updated, Version 10) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Vertebrata>
Protein name |
RecName:
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Full=NAD(P)H-hydrate epimerase;
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EC 5.1.99.6;
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AltName:
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Full=Apolipoprotein A-I-binding protein;
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Short=AI-BP;
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AltName:
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Full=NAD(P)HX epimerase;
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else
Protein name |
RecName:
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Full=NAD(P)H-hydrate epimerase;
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EC 5.1.99.6;
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AltName:
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Full=NAD(P)HX epimerase;
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|
end case
case <OC:Mammalia>
Function |
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. |
else
Function |
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. |
end case
case <OC:Fungi>
Subcellular location |
Cytoplasm. Mitochondrion. |
else case <OC:Mammalia>
Subunit |
Homodimer. Interacts with @gn(APOA1) and @gn(APOA2). |
Subcellular location |
Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation. |
Ptm |
Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. |
else case <OC:Vertebrata> and not <OC:Mammalia>
Subcellular location |
Mitochondrion. Secreted. |
end case
case <OC:Vertebrata> and not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the NnrE/AIBP family. |
case <OC:Fungi>
else case <OC:Vertebrata>
end case
GO:0052856; Molecular function: NADHX epimerase activity.
case <OC:Fungi>
else case <OC:Vertebrata>
end case
case <OC:Vertebrata>
General |
TransitM; -; 0-1; trigger=yes; |
end case
From: NNR_THEMA (Q9X024) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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51
|
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55
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NAD(P)HX
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x-[NQ]-G-x(2)
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REGION
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118
|
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124
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NAD(P)HX
|
|
|
|
|
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METAL
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52
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52
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Potassium
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|
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[NQ]
|
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METAL
|
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114
|
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114
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Potassium
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D
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METAL
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150
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150
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Potassium
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[ST]
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BINDING (Optional)
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129
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129
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NAD(P)HX
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Y
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BINDING
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147
|
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147
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NAD(P)HX
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[DE]
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Additional information
[?]
Size range |
204-292 amino acids |
Related rules |
None |
Fusion |
None |