HAMAP rule MF_03173

General rule information [?]

Accession	MF_03173
Dates	21-MAR-2013 (Created) 3-SEP-2024 (Last updated, Version 13)
Name	Adenylate_kinase_AK6_euk
Scope(s)	Eukaryota
Template(s)	Q9Y3D8 (KAD6_HUMAN); Q09527 (KAD6_CAEEL); Q7JYV7 (KAD6_DROME); [ Recover all ]
Triggered by	case c? <OC:Eukaryota> HAMAP; MF_00039 (Get profile general information and statistics) end case

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	KAD6
case <OC:Vertebrata>
Protein name	RecName: Full=Adenylate kinase isoenzyme 6; Short=AK6; EC=2.7.4.3; AltName: Full=Coilin-interacting nuclear ATPase protein; AltName: Full=Dual activity adenylate kinase/ATPase; Short=AK/ATPase;
Gene name	Name=AK6; Synonyms=CINAP;
else
Protein name	RecName: Full=Adenylate kinase isoenzyme 6 homolog; Short=AK6; EC=2.7.4.3; AltName: Full=Dual activity adenylate kinase/ATPase; Short=AK/ATPase;
end case

Comments [?]

case <OC:Vertebrata>
FUNCTION	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation.
else
FUNCTION	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.
end case
CATALYTIC ACTIVITY	Reaction=AMP + ATP = 2 ADP; Xref=Rhea:RHEA:12973, ChEBI:CHEBI:30616, ChEBI:CHEBI:456215, ChEBI:CHEBI:456216; EC=2.7.4.3;
CATALYTIC ACTIVITY	Reaction=ATP + H2O = ADP + phosphate + H(+); Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
case <OC:Vertebrata>
SUBUNIT	Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11. Interacts with COIL (via C-terminus).
SUBCELLULAR LOCATION	Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
else case <OC:Metazoa>
SUBUNIT	Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.
SUBCELLULAR LOCATION	Cytoplasm. Nucleus.
else
SUBUNIT	Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.
SUBCELLULAR LOCATION	Cytoplasm. Nucleus.
end case
SIMILARITY	Belongs to the adenylate kinase family. AK6 subfamily.

Keywords [?]

Gene Ontology [?]

case <OCellular component:Vertebrata>
GO:0015030; Cellular component:Cajal body
end case
GO:0005737; Cellular component:cytoplasm
GO:0005634; Cellular component:nucleus
GO:0004017; Molecular function:adenylate kinase activity
GO:0016887; Molecular function:ATP hydrolysis activity
GO:0042274; Biological process:ribosomal small subunit biogenesis

Cross-references [?]

Pfam	PF01202; SKI; 0-1;
PRINTS	PR01100; SHIKIMTKNASE; 0-1;

Features [?]

From: KAD6_HUMAN (Q9Y3D8)

Key

From

Description

Tag

Condition

FTGroup

REGION

/note="NMPbind"

REGION

108

118

/note="LID"

BINDING