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HAMAP rule MF_03173

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General rule information [?]

Accession MF_03173
Dates 21-MAR-2013 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Adenylate_kinase_AK6_euk
Scope
Eukaryota
Templates Q9Y3D8 (KAD6_HUMAN); Q09527 (KAD6_CAEEL); Q7JYV7 (KAD6_DROME): [Recover all]
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
KAD6
case <OC:Vertebrata>
Protein name
RecName: Full=Adenylate kinase isoenzyme 6;
Short=AK6;
EC 2.7.4.3;
AltName: Full=Coilin-interacting nuclear ATPase protein;
AltName: Full=Dual activity adenylate kinase/ATPase;
Short=AK/ATPase;
Gene name
AK6, CINAP
else
Protein name
RecName: Full=Adenylate kinase isoenzyme 6 homolog;
Short=AK6;
EC 2.7.4.3;
AltName: Full=Dual activity adenylate kinase/ATPase;
Short=AK/ATPase;
end case

Comments [?]

case <OC:Vertebrata>
Function Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
else case <OC:Metazoa>
Function Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity.
else case <OC:Fungi>
Function Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.
else
Function Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.
end case
Catalytic activity RHEA:12973: AMP + ATP = 2 ADP
EC 2.7.4.3
case <OC:Vertebrata>
Subunit Monomer and homodimer. Interacts with COIL (via C-terminus).
Subcellular location Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.
else case <OC:Metazoa>
Subunit Monomer and homodimer.
Subcellular location Nucleus.
else case <OC:Fungi>
Subcellular location Cytoplasm. Nucleus.
end case
Similarity Belongs to the adenylate kinase family. AK6 subfamily.

Keywords [?]

ATP-binding
Kinase
Nucleotide-binding
Transferase
case <OC:Metazoa> or <OC:Fungi>
Nucleus
end case
case <OC:Fungi>
Cytoplasm
Ribosome biogenesis
rRNA processing
Transcription
Transcription regulation
end case

Gene Ontology [?]

case <OC:Vertebrata>
GO:0015030; Cellular component: Cajal body.
else case <OC:Fungi>
GO:0005737; Cellular component: cytoplasm.
end case
GO:0005634; Cellular component: nucleus.
GO:0004017; Molecular function: adenylate kinase activity.
GO:0016887; Molecular function: ATP hydrolysis activity.

Cross-references [?]

Pfam PF01202; SKI; 0-1;
PRINTS PR01100; SHIKIMTKNASE; 0-1;

Features [?]

From: KAD6_HUMAN (Q9Y3D8)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     13     18       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     G-x-G-K-[ST]-[ST]  
case <OC:Vertebrata>
BINDING     148     149       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [KE]-P  
end case
REGION     33     56       NMPbind        
REGION     108     118       LID        
BINDING     39     39       /ligand="AMP" /ligand_id="ChEBI:CHEBI:456215     [RK]  
BINDING     79     79       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     H  
BINDING     105     105       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  
BINDING     109     109       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     R  

Additional information [?]

Size range 148-248 amino acids
Related rules None
Fusion None


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