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Annotation rule MF_03187
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General rule information [?]

Accession MF_03187
Dates 13-FEB-2015 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Methyltr_EFM5
Scope
Eukaryota
Template P53200 (EFM5_YEAST)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Vertebrata>
Identifier
EFMT1
Protein name
RecName: Full=EEF1A lysine methyltransferase 1;
EC 2.1.1.-;
AltName: Full=N(6)-adenine-specific DNA methyltransferase 2;
AltName: Full=Protein-lysine N-methyltransferase N6AMT2;
Gene name
EEF1AKMT1, N6AMT2
else case <OC:Fungi>
Identifier
EFM5
Protein name
RecName: Full=Protein-lysine N-methyltransferase ;
EC 2.1.1.-;
AltName: Full=Elongation factor methyltransferase 5;
Gene name
EFM5
else
Protein name
RecName: Full=Protein-lysine N-methyltransferase ;
EC 2.1.1.-;
end case

Comments [?]

case <OC:Vertebrata>
Function Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.
else case <OC:Fungi>
Function S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'.
else
Function S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.
end case
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.
case <OC:Vertebrata>
Caution Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.
end case

Keywords [?]

Cytoplasm
Methyltransferase
Transferase

Gene Ontology [?]

GO:0005737; Cellular component: cytoplasm.
GO:0016279; Molecular function: protein-lysine N-methyltransferase activity.
GO:0018022; Biological process: peptidyl-lysine methylation.

Cross-references [?]

Pfam PF10237; N6-adenineMlase; 1;

Additional information [?]

Size range 205-277 amino acids
Related rules None
Fusion None


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