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Annotation rule MF_03189
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General rule information [?]

Accession MF_03189
Dates 6-MAR-2015 (Created)
10-DEC-2019 (Last updated, Version 8)
Name UbiA_COQ2_euk
Scope
Eukaryota
Template P32378 (COQ2_YEAST)
case <OC:Eukaryota>
Triggered by
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
COQ2
Protein name
RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
Short=4-HB polyprenyltransferase;
EC 2.5.1.39;
AltName: Full=Para-hydroxybenzoate--polyprenyltransferase;
Short=PHB:PPT;
Short=PHB:polyprenyltransferase;
case <OC:Hominidae> or <OC:Schizosaccharomycetes>
Protein name
Full=4-hydroxybenzoate decaprenyltransferase;
else case <OC:Arabidopsis>
Protein name
Full=4-hydroxybenzoate nonaprenyltransferase;
else case <OC:Saccharomycotina>
Protein name
Full=4-hydroxybenzoate hexaprenyltransferase;
end case
case <OC:Vertebrata> or <OC:Saccharomycotina>
Gene name
COQ2
else case <OC:Drosophilidae>
Gene name
Coq2
else case <OC:Insecta> or <OC:Dictyostelia>
Gene name
coq2
else case <OC:Caenorhabditis>
Gene name
coq-2
else case <OC:Schizosaccharomycetes>
Gene name
ppt1
else case <OC:Arabidopsis>
Gene name
PPT1
end case

Comments [?]

Function Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.
Catalytic activity RHEA:44504: 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
EC 2.5.1.39
Cofactor Mg(2+)
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Subcellular location Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case
Similarity Belongs to the UbiA prenyltransferase family.

Keywords [?]

Isoprene biosynthesis
Membrane
Mitochondrion
Mitochondrion inner membrane
Transferase
Transmembrane
Transmembrane helix
Ubiquinone biosynthesis

Gene Ontology [?]

GO:0031305; Cellular component: integral component of mitochondrial inner membrane.
case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO:0002083; Molecular function: 4-hydroxybenzoate decaprenyltransferase activity.
else case <OC:Arabidopsis>
GO:0047293; Molecular function: 4-hydroxybenzoate nonaprenyltransferase activity.
else
GO:0002094; Molecular function: polyprenyltransferase activity.
end case
GO:0008299; Biological process: isoprenoid biosynthetic process.
GO:0006744; Biological process: ubiquinone biosynthetic process.

Cross-references [?]

PROSITE PS00943; UBIA; 1;
Pfam PF01040; UbiA; 1;
TIGRFAMs TIGR01474; ubiA_proteo; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;
Transmembrane; -; 0-9; trigger=yes;

Features [?]

From: COQ2_YEAST (P32378)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     134     156       Allylic polyprenyl diphosphate-binding site     x(5)-[CH]-x(2)-N-D-x(2)-D-x(3)-D-x(2)-[VI]-x-R-[ST]  

Additional information [?]

Size range 277-490 amino acids
Related rules None
Fusion None


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