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Annotation rule MF_03189 |
General rule information
[?]
Accession |
MF_03189 |
Dates |
6-MAR-2015 (Created) 10-DEC-2019 (Last updated, Version 8) |
case <OC:Eukaryota>
end case
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial;
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Short=4-HB polyprenyltransferase;
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EC 2.5.1.39;
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AltName:
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Full=Para-hydroxybenzoate--polyprenyltransferase;
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Short=PHB:PPT;
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Short=PHB:polyprenyltransferase;
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case <OC:Hominidae> or <OC:Schizosaccharomycetes>
Protein name |
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Full=4-hydroxybenzoate decaprenyltransferase;
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else case <OC:Arabidopsis>
Protein name |
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Full=4-hydroxybenzoate nonaprenyltransferase;
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else case <OC:Saccharomycotina>
Protein name |
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Full=4-hydroxybenzoate hexaprenyltransferase;
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end case
case <OC:Vertebrata> or <OC:Saccharomycotina>
else case <OC:Drosophilidae>
else case <OC:Insecta> or <OC:Dictyostelia>
else case <OC:Caenorhabditis>
else case <OC:Schizosaccharomycetes>
else case <OC:Arabidopsis>
end case
Function |
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. |
Catalytic activity |
RHEA:44504: 4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate
EC 2.5.1.39
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Cofactor |
Mg(2+) |
Pathway |
Cofactor biosynthesis; ubiquinone biosynthesis. |
Subcellular location |
Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side. |
case not <AnyFeature:TransitM>
Miscellaneous |
This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Similarity |
Belongs to the UbiA prenyltransferase family. |
GO:0031305; Cellular component: integral component of mitochondrial inner membrane.
case <OC:Hominidae> or <OC:Schizosaccharomycetes>
GO:0002083; Molecular function: 4-hydroxybenzoate decaprenyltransferase activity.
else case <OC:Arabidopsis>
GO:0047293; Molecular function: 4-hydroxybenzoate nonaprenyltransferase activity.
else
GO:0002094; Molecular function: polyprenyltransferase activity.
end case
GO:0008299; Biological process: isoprenoid biosynthetic process.
GO:0006744; Biological process: ubiquinone biosynthetic process.
General |
TransitM; -; 0-1; trigger=yes; |
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Transmembrane; -; 0-9; trigger=yes; |
From: COQ2_YEAST (P32378) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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REGION
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134
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156
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Allylic polyprenyl diphosphate-binding site
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x(5)-[CH]-x(2)-N-D-x(2)-D-x(3)-D-x(2)-[VI]-x-R-[ST]
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Additional information
[?]
Size range |
277-490 amino acids |
Related rules |
None |
Fusion |
None |