HAMAP rule MF_03189
General rule information
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| Accession | MF_03189 |
| Dates | 6-MAR-2015 (Created)
1-JUN-2023 (Last updated, Version 12) |
| Name | UbiA_COQ2_euk |
| Scope(s) |
Eukaryota |
| Template(s) | P32378 (COQ2_YEAST); Q96H96 (COQ2_HUMAN); Q66JT7 (COQ2_MOUSE); Q499N4 (COQ2_RAT); [ Recover all ] |
| Triggered by |
case c? <OC:Eukaryota>
HAMAP; MF_01635 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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| Identifier | COQ2 |
| Protein name | RecName: Full=4-hydroxybenzoate polyprenyltransferase, mitochondrial; Short=4-HB polyprenyltransferase; EC=2.5.1.39; AltName: Full=Para-hydroxybenzoate--polyprenyltransferase; Short=PHB:PPT; Short=PHB:polyprenyltransferase; |
| case <OC:Hominidae> or <OC:Schizosaccharomycetes> | |
| Protein name | + AltName: Full=4-hydroxybenzoate decaprenyltransferase; |
| else case <OC:Arabidopsis> | |
| Protein name | + AltName: Full=4-hydroxybenzoate nonaprenyltransferase; |
| else case <OC:Saccharomycotina> | |
| Protein name | + AltName: Full=4-hydroxybenzoate hexaprenyltransferase; |
| end case | |
| case <OC:Vertebrata> or <OC:Saccharomycotina> | |
| Gene name | Name=COQ2; |
| else case <OC:Drosophilidae> | |
| Gene name | Name=Coq2; |
| else case <OC:Insecta> or <OC:Dictyostelia> | |
| Gene name | Name=coq2; |
| else case <OC:Caenorhabditis> | |
| Gene name | Name=coq-2; |
| else case <OC:Schizosaccharomycetes> | |
| Gene name | Name=ppt1; |
| else case <OC:Arabidopsis> | |
| Gene name | Name=PPT1; |
| end case | |
Comments
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| case <OC:Hominidae> or <OC:Rodentia> | |
| FUNCTION | Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis. Catalyzes the prenylation of para- hydroxybenzoate (PHB) with an all-trans polyprenyl donor (such as all- trans-decaprenyl diphosphate or trans-nonaprenyl diphosphate). The length of the polyprenyl side chain varies depending on the species, in humans, the side chain is comprised of 10 isoprenyls producing CoQ10 (also known as ubiquinone), whereas rodents predominantly generate CoQ9. However, this specificity is not complete, human tissues have low amounts of CoQ9 and rodent organs contain some CoQ10. CoQs are vital molecules that transport electrons from mitochondrial respiratory chain complexes. CoQs also function as cofactors for uncoupling protein and play a role as regulators of the extracellularly-induced ceramide- dependent apoptotic pathway. Regulates mitochondrial permeability transition pore (mPTP) opening and ROS production (pivotal events in cell death) in a tissue specific manner. |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4- hydroxy-3-all-trans-polyprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44504, Rhea:RHEA-COMP:9514, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58914, ChEBI:CHEBI:78396; EC=2.5.1.39; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44505; |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-decaprenyl diphosphate = 4- hydroxy-3-all-trans-decaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:60721, ChEBI:CHEBI:84503; EC=2.5.1.39; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44565; |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + all-trans-nonaprenyl diphosphate = 4- hydroxy-3-all-trans-nonaprenylbenzoate + diphosphate; Xref=Rhea:RHEA:17709, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58391, ChEBI:CHEBI:84502; EC=2.5.1.39; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:17710; |
| else | |
| FUNCTION | Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. |
| CATALYTIC ACTIVITY | Reaction=4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4- hydroxy-3-all-trans-polyprenylbenzoate + diphosphate; Xref=Rhea:RHEA:44504, Rhea:RHEA-COMP:9514, Rhea:RHEA-COMP:9564, ChEBI:CHEBI:17879, ChEBI:CHEBI:33019, ChEBI:CHEBI:58914, ChEBI:CHEBI:78396; EC=2.5.1.39; |
| end case | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| PATHWAY | Cofactor biosynthesis; ubiquinone biosynthesis. |
| SUBCELLULAR LOCATION | Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side. |
| case not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
| SIMILARITY | Belongs to the UbiA prenyltransferase family. |
Keywords
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| Isoprene biosynthesis |
| Membrane |
| Mitochondrion |
| Mitochondrion inner membrane |
| Transferase |
| Transmembrane |
| Transmembrane helix |
| Ubiquinone biosynthesis |
Gene Ontology
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| GO:0005743; Cellular component:mitochondrial inner membrane | |
| case <OCellular component:Hominidae> or <OC:Schizosaccharomycetes> | |
| GO:0002083; Molecular function:4-hydroxybenzoate decaprenyltransferase activity | |
| else case <OCellular component:Arabidopsis> | |
| GO:0047293; Molecular function:4-hydroxybenzoate nonaprenyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0002094; Molecular function:polyprenyltransferase activity | |
| end case | |
| GO:0008299; Biological process:isoprenoid biosynthetic process | |
| GO:0006744; Biological process:ubiquinone biosynthetic process | |
Cross-references
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| PROSITE | PS00943; UBIA; 1; |
| Pfam | PF01040; UbiA; 1; |
| NCBIfam | TIGR01474; ubiA_proteo; 1; |
| General | TransitM; -; 0-1; |
| General | Transmembrane; -; 0-9; |
Features
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Additional information
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| Size range | 277-490 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |