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HAMAP rule MF_03210

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General rule information [?]

Accession MF_03210
Dates 6-NOV-2015 (Created)
19-NOV-2022 (Last updated, Version 8)
Name Formate_dehydrogenase
Scope
Bacteria
Eukaryota
Templates P33160 (FDH_PSESR); O13437 (FDH_CANBO); Q08911 (FDH1_YEAST); G0SGU4 (FDH_CHATD); Q07511 (FDH_SOLTU); Q9S7E4 (FDH_ARATH): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FDH
case <OC:Viridiplantae>
Protein name
RecName: Full=Formate dehydrogenase, mitochondrial;
Short=FDH;
EC 1.17.1.9;
AltName: Full=NAD-dependent formate dehydrogenase;
else
Protein name
RecName: Full=Formate dehydrogenase;
Short=FDH;
EC 1.17.1.9;
AltName: Full=NAD-dependent formate dehydrogenase;
end case

Comments [?]

case <OC:Viridiplantae>
Function Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.
else
Function Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
end case
Catalytic activity RHEA:15985: formate + NAD(+) = CO2 + NADH
EC 1.17.1.9
Subunit Homodimer.
case <OC:Viridiplantae>
Subcellular location Mitochondrion.
else
Subcellular location Cytoplasm.
end case
Similarity Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
case <OC:Viridiplantae> and not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case

Keywords [?]

case <OC:Viridiplantae>
Mitochondrion
else
Cytoplasm
end case
NAD
Oxidoreductase

Gene Ontology [?]

case <OC:Viridiplantae>
GO:0005739; Cellular component: mitochondrion.
else
GO:0005737; Cellular component: cytoplasm.
end case
GO:0008863; Molecular function: formate dehydrogenase (NAD+) activity.
GO:0042183; Biological process: formate catabolic process.

Cross-references [?]

PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1;
PS00670; D_2_HYDROXYACID_DH_2; 1;
PS00671; D_2_HYDROXYACID_DH_3; 1;
Pfam PF00389; 2-Hacid_dh; 1;
PF02826; 2-Hacid_dh_C; 1;

Computed features [?]

case <OC:Viridiplantae>
General TransitM; -; 0-1; trigger=yes;
end case

Features [?]

From: FDH_PSESR (P33160)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     202     203       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     R-I  
BINDING     257     261       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     P-L-[HTY]-x(2)  
BINDING     333     336       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     H-x-S-G  
BINDING     123     123       /ligand="substrate     [IV]  
BINDING     147     147       /ligand="substrate     N  
BINDING (Optional)     148     148       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [ST]  
BINDING     222     222       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     D  
BINDING     283     283       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [TN]  
BINDING     309     309       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     D  
BINDING (Optional)     381     381       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     S  
SITE     285     285       Important for catalytic activity     R  
SITE     333     333       Important for catalytic activity     H  

Additional information [?]

Size range 341-402 amino acids
Related rules None
Fusion None


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