HAMAP logo
Due to maintenance work, this service will be unavailable Tuesday 16 between 06:00 and 06:30 - CEST. Apologies for the inconvenience.

HAMAP rule MF_03210

Send feedback

General rule information [?]

Accession MF_03210
Dates 6-NOV-2015 (Created)
19-NOV-2022 (Last updated, Version 8)
Name Formate_dehydrogenase
Scope(s) Bacteria
Eukaryota
Template(s) P33160 (FDH_PSESR); O13437 (FDH_CANBO); Q08911 (FDH1_YEAST); G0SGU4 (FDH_CHATD); Q07511 (FDH_SOLTU); Q9S7E4 (FDH_ARATH); [ Recover all ]
Triggered by HAMAP; MF_03210 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FDH
case <OC:Viridiplantae>
Protein name RecName: Full=Formate dehydrogenase, mitochondrial;
                 Short=FDH;
                 EC=1.17.1.9;
AltName: Full=NAD-dependent formate dehydrogenase;
else
Protein name RecName: Full=Formate dehydrogenase;
                 Short=FDH;
                 EC=1.17.1.9;
AltName: Full=NAD-dependent formate dehydrogenase;
end case

Comments [?]

case <OC:Viridiplantae>
FUNCTIONCatalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response.
else
FUNCTIONCatalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.
end case
CATALYTIC ACTIVITY Reaction=formate + NAD(+) = CO2 + NADH; Xref=Rhea:RHEA:15985, ChEBI:CHEBI:15740, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.17.1.9;
SUBUNITHomodimer.
case <OC:Viridiplantae>
SUBCELLULAR LOCATIONMitochondrion.
else
SUBCELLULAR LOCATIONCytoplasm.
end case
SIMILARITYBelongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.
case <OC:Viridiplantae> and not <AnyFeature:TransitM>
MISCELLANEOUSThis protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case

Keywords [?]

case <OC:Viridiplantae>
Mitochondrion
else
Cytoplasm
end case
NAD
Oxidoreductase

Gene Ontology [?]

case <OCellular component:Viridiplantae>
GO:0005739; Cellular component:mitochondrion
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0005737; Cellular component:cytoplasm
end case
GO:0008863; Molecular function:formate dehydrogenase (NAD+) activity
GO:0042183; Biological process:formate catabolic process

Cross-references [?]

PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1;
PROSITE PS00670; D_2_HYDROXYACID_DH_2; 1;
PROSITE PS00671; D_2_HYDROXYACID_DH_3; 1;
Pfam PF00389; 2-Hacid_dh; 1;
Pfam PF02826; 2-Hacid_dh_C; 1;
General TransitM; -; 0-1;

Features [?]

From: FDH_PSESR (P33160)
Key From To Description Tag Condition FTGroup
BINDING 202 203 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
R-I
BINDING 257 261 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
P-L-[HTY]-x(2)
BINDING 333 336 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
H-x-S-G
BINDING 123 123 /ligand="substrate" [IV]
BINDING 147 147 /ligand="substrate" N
BINDING 148 148 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
[ST]
BINDING 222 222 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
D
BINDING 283 283 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
[TN]
BINDING 309 309 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
D
BINDING 381 381 /ligand="NAD(+)"
/ligand_id="ChEBI:CHEBI:57540"
S
SITE 285 285 /note="Important for catalytic activity" R
SITE 333 333 /note="Important for catalytic activity" H

Additional information [?]

Size range 341-402 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)