HAMAP rule MF_03210
General rule information
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| Accession | MF_03210 |
| Dates | 6-NOV-2015 (Created)
19-NOV-2022 (Last updated, Version 8) |
| Name | Formate_dehydrogenase |
| Scope(s) |
Bacteria Eukaryota |
| Template(s) | P33160 (FDH_PSESR); O13437 (FDH_CANBO); Q08911 (FDH1_YEAST); G0SGU4 (FDH_CHATD); Q07511 (FDH_SOLTU); Q9S7E4 (FDH_ARATH); [ Recover all ] |
| Triggered by |
HAMAP; MF_03210 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FDH |
| case <OC:Viridiplantae> | |
| Protein name | RecName: Full=Formate dehydrogenase, mitochondrial; Short=FDH; EC=1.17.1.9; AltName: Full=NAD-dependent formate dehydrogenase; |
| else | |
| Protein name | RecName: Full=Formate dehydrogenase; Short=FDH; EC=1.17.1.9; AltName: Full=NAD-dependent formate dehydrogenase; |
| end case | |
Comments
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| case <OC:Viridiplantae> | |
| FUNCTION | Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response. |
| else | |
| FUNCTION | Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. |
| end case | |
| CATALYTIC ACTIVITY | Reaction=formate + NAD(+) = CO2 + NADH; Xref=Rhea:RHEA:15985, ChEBI:CHEBI:15740, ChEBI:CHEBI:16526, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.17.1.9; |
| SUBUNIT | Homodimer. |
| case <OC:Viridiplantae> | |
| SUBCELLULAR LOCATION | Mitochondrion. |
| else | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| end case | |
| SIMILARITY | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. |
| case <OC:Viridiplantae> and not <AnyFeature:TransitM> | |
| MISCELLANEOUS | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
| end case | |
Keywords
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| case <OC:Viridiplantae> | |
| Mitochondrion | |
| else | |
| Cytoplasm | |
| end case | |
| NAD | |
| Oxidoreductase | |
Gene Ontology
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| case <OCellular component:Viridiplantae> | |
| GO:0005739; Cellular component:mitochondrion | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0005737; Cellular component:cytoplasm | |
| end case | |
| GO:0008863; Molecular function:formate dehydrogenase (NAD+) activity | |
| GO:0042183; Biological process:formate catabolic process | |
Cross-references
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| PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
| PROSITE | PS00670; D_2_HYDROXYACID_DH_2; 1; |
| PROSITE | PS00671; D_2_HYDROXYACID_DH_3; 1; |
| Pfam | PF00389; 2-Hacid_dh; 1; |
| Pfam | PF02826; 2-Hacid_dh_C; 1; |
| General | TransitM; -; 0-1; |
Features
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| From: FDH_PSESR (P33160) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 202 | 203 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
R-I | ||||||||
| BINDING | 257 | 261 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
P-L-[HTY]-x(2) | ||||||||
| BINDING | 333 | 336 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
H-x-S-G | ||||||||
| BINDING | 123 | 123 | /ligand="substrate" | [IV] | ||||||||
| BINDING | 147 | 147 | /ligand="substrate" | N | ||||||||
| BINDING | 148 | 148 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[ST] | ||||||||
| BINDING | 222 | 222 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
| BINDING | 283 | 283 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[TN] | ||||||||
| BINDING | 309 | 309 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
| BINDING | 381 | 381 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
S | ||||||||
| SITE | 285 | 285 | /note="Important for catalytic activity" | R | ||||||||
| SITE | 333 | 333 | /note="Important for catalytic activity" | H | ||||||||
Additional information
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| Size range | 341-402 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |