HAMAP rule MF_03210
General rule information
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Accession | MF_03210 |
Dates | 6-NOV-2015 (Created) 19-NOV-2022 (Last updated, Version 8) |
Name | Formate_dehydrogenase |
Scope | Bacteria
Eukaryota |
Templates | P33160 (FDH_PSESR); O13437 (FDH_CANBO); Q08911 (FDH1_YEAST); G0SGU4 (FDH_CHATD); Q07511 (FDH_SOLTU); Q9S7E4 (FDH_ARATH): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Viridiplantae>
Protein name |
|
else
Protein name |
|
end case
Comments
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case <OC:Viridiplantae>
Function | Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Involved in the cell stress response. |
else
Function | Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. |
end case
Catalytic activity | RHEA:15985: formate + NAD(+) = CO2 + NADH
EC 1.17.1.9 |
Subunit | Homodimer. |
case <OC:Viridiplantae>
Subcellular location | Mitochondrion. |
else
Subcellular location | Cytoplasm. |
end case
Similarity | Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. |
case <OC:Viridiplantae> and not <AnyFeature:TransitM>
Miscellaneous | This protein may be expected to contain an N-terminal transit peptide but none has been predicted. |
end case
Keywords
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case <OC:Viridiplantae>
else
end case
Gene Ontology
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case <OC:Viridiplantae>
GO:0005739; Cellular component: mitochondrion.
else
GO:0005737; Cellular component: cytoplasm.
end case
GO:0008863; Molecular function: formate dehydrogenase (NAD+) activity.
GO:0042183; Biological process: formate catabolic process.
GO:0042183; Biological process: formate catabolic process.
Cross-references
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PROSITE | PS00065; D_2_HYDROXYACID_DH_1; 1; |
PS00670; D_2_HYDROXYACID_DH_2; 1; | |
PS00671; D_2_HYDROXYACID_DH_3; 1; | |
Pfam | PF00389; 2-Hacid_dh; 1; |
PF02826; 2-Hacid_dh_C; 1; |
Computed features
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case <OC:Viridiplantae>
General | TransitM; -; 0-1; trigger=yes; |
end case
Features
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From: FDH_PSESR (P33160) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 202 | 203 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | R-I | ||||||||
BINDING | 257 | 261 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | P-L-[HTY]-x(2) | ||||||||
BINDING | 333 | 336 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | H-x-S-G | ||||||||
BINDING | 123 | 123 | /ligand="substrate | [IV] | ||||||||
BINDING | 147 | 147 | /ligand="substrate | N | ||||||||
BINDING (Optional) | 148 | 148 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [ST] | ||||||||
BINDING | 222 | 222 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | D | ||||||||
BINDING | 283 | 283 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [TN] | ||||||||
BINDING | 309 | 309 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | D | ||||||||
BINDING (Optional) | 381 | 381 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | S | ||||||||
SITE | 285 | 285 | Important for catalytic activity | R | ||||||||
SITE | 333 | 333 | Important for catalytic activity | H |
Additional information
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Size range | 341-402 amino acids |
Related rules | None |
Fusion | None |