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Annotation rule MF_03211
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General rule information [?]

Accession MF_03211
Dates 11-NOV-2015 (Created)
20-NOV-2019 (Last updated, Version 7)
Name RNA_acetyltr_Nat10
Scope
Eukaryota
Templates P53914 (NAT10_YEAST); P87115 (NAT10_SCHPO); Q9H0A0 (NAT10_HUMAN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NAT10
Protein name
RecName: Full=RNA cytidine acetyltransferase;
EC 2.3.1.-;
AltName: Full=18S rRNA cytosine acetyltransferase;
case <OC:Mammalia>
Protein name
Full=N-acetyltransferase 10;
end case
case <OC:Vertebrata> or <OC:Fungi>
Gene name
NAT10
else case <OC:Caenorhabditis>
Gene name
nath-10
end case

Comments [?]

case <OC:Vertebrata>
Function RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein @gn(THUMPD1) for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
else case <OC:Fungi>
Function RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein @gn(TAN1) for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
else
Function RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
end case
Catalytic activity RHEA:51424: a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
RHEA:53876: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate
case <OC:Vertebrata>
Subunit Interacts with @gn(THUMPD1).
else case <OC:Fungi>
Subunit Interacts with @gn(TAN1).
end case
Subcellular location Nucleus, nucleolus.
Similarity Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Keywords [?]

Acyltransferase
ATP-binding
Nucleotide-binding
Nucleus
rRNA processing
Transferase
tRNA processing

Gene Ontology [?]

GO:0005730; Cellular component: nucleolus.
GO:0005524; Molecular function: ATP binding.
GO:0008080; Molecular function: N-acetyltransferase activity.
GO:0051391; Biological process: tRNA acetylation.
GO:0000154; Biological process: rRNA modification.
GO:0042274; Biological process: ribosomal small subunit biogenesis.

Cross-references [?]

PROSITE PS51186; GNAT; 1; trigger=PRU00532;
Pfam PF08351; DUF1726; 1;
PF13718; GNAT_acetyltr_2; 1;
PF05127; Helicase_RecD; 1;
PF13725; tRNA_bind_2; 1;

Features [?]

From: NAT10_YEAST (P53914)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     286     295       ATP     G-R-G-K-S-A-[TAS]-[IVLM]-G-[IVLM]  
REGION (Optional)     638     640       Acetyl-CoA binding     [IV]-A-[ATV]  
REGION (Optional)     645     651       Acetyl-CoA binding     x(2)-[MLA]-[GN]-Y-G-x  
BINDING (Optional)     475     475       ATP     R  
BINDING (Optional)     739     739       Acetyl-CoA     [RKN]  

Additional information [?]

Size range 825-1233 amino acids
Related rules None
Fusion None


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