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Annotation rule MF_03211 |
General rule information
[?]
Accession |
MF_03211 |
Dates |
11-NOV-2015 (Created) 20-NOV-2019 (Last updated, Version 7) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=RNA cytidine acetyltransferase;
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EC 2.3.1.-;
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AltName:
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Full=18S rRNA cytosine acetyltransferase;
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case <OC:Mammalia>
Protein name |
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Full=N-acetyltransferase 10;
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end case
case <OC:Vertebrata> or <OC:Fungi>
else case <OC:Caenorhabditis>
end case
case <OC:Vertebrata>
Function |
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein @gn(THUMPD1) for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. |
else case <OC:Fungi>
Function |
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein @gn(TAN1) for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. |
else
Function |
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. |
end case
Catalytic activity |
RHEA:51424: a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
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RHEA:53876: a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate
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case <OC:Vertebrata>
Subunit |
Interacts with @gn(THUMPD1). |
else case <OC:Fungi>
Subunit |
Interacts with @gn(TAN1). |
end case
Subcellular location |
Nucleus, nucleolus. |
Similarity |
Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily. |
GO:0005730; Cellular component: nucleolus.
GO:0005524; Molecular function: ATP binding.
GO:0008080; Molecular function: N-acetyltransferase activity.
GO:0051391; Biological process: tRNA acetylation.
GO:0000154; Biological process: rRNA modification.
GO:0042274; Biological process: ribosomal small subunit biogenesis.
From: NAT10_YEAST (P53914) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND (Optional)
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286
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295
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ATP
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G-R-G-K-S-A-[TAS]-[IVLM]-G-[IVLM]
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REGION (Optional)
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638
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640
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Acetyl-CoA binding
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[IV]-A-[ATV]
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REGION (Optional)
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645
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651
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Acetyl-CoA binding
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x(2)-[MLA]-[GN]-Y-G-x
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BINDING (Optional)
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475
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475
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ATP
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R
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BINDING (Optional)
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739
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739
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Acetyl-CoA
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[RKN]
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Additional information
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Size range |
825-1233 amino acids |
Related rules |
None |
Fusion |
None |