HAMAP rule MF_03217

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_03217
Accession	MF_03217
Dates	11-JUL-2016 (Created) 03-SEP-2024 (Last updated, Version 7)
Name	PEMT
Scope(s)	Eukaryota Fungi
Template(s)	P05374; Q7SAJ6; [ Recover all ]
Triggered by	HAMAP; MF_03217 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CHO2
Protein name	RecName: Full=Phosphatidylethanolamine N-methyltransferase; Short=PE methyltransferase; Short=PEAMT; Short=PEMT; EC=2.1.1.17;

Comments [?]

FUNCTION	Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
CATALYTIC ACTIVITY	Reaction=a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L- methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:11164, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:64573, ChEBI:CHEBI:64612; EC=2.1.1.17;
PATHWAY	Phospholipid metabolism; phosphatidylcholine biosynthesis.
SUBCELLULAR LOCATION	Endoplasmic reticulum membrane; Multi-pass membrane protein.
SIMILARITY	Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.

Keywords [?]

Gene Ontology [?]

GO:0005789; Cellular component:endoplasmic reticulum membrane

GO:0004608; Molecular function:phosphatidylethanolamine N-methyltransferase activity

GO:0006656; Biological process:phosphatidylcholine biosynthetic process

Cross-references [?]

Features [?]

Additional information [?]