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Annotation rule MF_03217
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General rule information [?]

Accession MF_03217
Dates 11-JUL-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name PEMT
Scope
Eukaryota; Fungi
Templates P05374 (CHO2_YEAST); Q7SAJ6 (CHO2_NEUCR): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CHO2
Protein name
RecName: Full=Phosphatidylethanolamine N-methyltransferase;
Short=PE methyltransferase;
Short=PEAMT;
Short=PEMT;
EC 2.1.1.17;

Comments [?]

Function Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Catalytic activity RHEA:11164: a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.17
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis.
Subcellular location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Similarity Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.

Keywords [?]

Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
Methyltransferase
Phospholipid biosynthesis
Phospholipid metabolism
S-adenosyl-L-methionine
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0005789; Cellular component: endoplasmic reticulum membrane.
GO:0004608; Molecular function: phosphatidylethanolamine N-methyltransferase activity.
GO:0006656; Biological process: phosphatidylcholine biosynthetic process.

Cross-references [?]

PROSITE PS51598; SAM_CHO2; 1;
PS50244; S5A_REDUCTASE; 0-1;
Pfam PF04191; PEMT; 2;
PIRSF PIRSF000383; PEAMT; 1;

Computed features [?]

General Transmembrane; -; 11;
ADD_TOPO_DOMAIN Lumenal; -; 6; trigger=yes;
Cytoplasmic; -; 6; trigger=yes;

Additional information [?]

Size range 837-1077 amino acids
Related rules None
Fusion None


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