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Annotation rule MF_03222
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General rule information [?]

Accession MF_03222
Dates 20-OCT-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name Succ_CoA_alpha_euk
Scope
Eukaryota
Templates O19069 (SUCA_PIG); Q9YGD2 (SUCA_COLLI): [Recover all]
case <OC:Eukaryota>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SUCA
case <OC:Metazoa> or <OC:Amoebozoa>
Protein name
RecName: Full=Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial;
EC 6.2.1.4;
EC 6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit alpha;
Short=SCS-alpha;
else
Protein name
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial;
EC 6.2.1.5;
AltName: Full=Succinyl-CoA synthetase subunit alpha;
Short=SCS-alpha;
end case
case <OC:Vertebrata>
Gene name
SUCLG1
end case

Comments [?]

case <OC:Metazoa> or <OC:Amoebozoa>
Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
Catalytic activity RHEA:22120: CoA + GTP + succinate = GDP + phosphate + succinyl-CoA
EC 6.2.1.4
else
Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
end case
Catalytic activity RHEA:17661: ATP + CoA + succinate = ADP + phosphate + succinyl-CoA
EC 6.2.1.5
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.
case <OC:Vertebrata>
Subunit Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit @gn(SUCLA2), forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit @gn(SUCLG2) forms a GDP-forming succinyl-CoA synthetase (G-SCS).
else case <OC:Metazoa> or <OC:Amoebozoa>
Subunit Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with an ATP-specific beta subunit, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with a GTP-specific beta subunit forms a GDP-forming succinyl-CoA synthetase (G-SCS).
else
Subunit Heterodimer of an alpha and a beta subunit.
end case
Subcellular location Mitochondrion.
Similarity Belongs to the succinate/malate CoA ligase alpha subunit family.
case not <AnyFeature:TransitM>
Miscellaneous This protein may be expected to contain an N-terminal transit peptide but none has been predicted.
end case

Keywords [?]


Gene Ontology [?]

GO:0004775; Molecular function: succinate-CoA ligase (ADP-forming) activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

PROSITE PS01216; SUCCINYL_COA_LIG_1; 1;
PS00399; SUCCINYL_COA_LIG_2; 1;
Pfam PF02629; CoA_binding; 1;
PF00549; Ligase_CoA; 1;
PF13607; Succ_CoA_lig; 1;
PRINTS PR01798; SCOASYNTHASE; 1;
TIGRFAMs TIGR01019; sucCoAalpha; 1;
PIRSF PIRSF001553; SucCS_alpha; 1;

Computed features [?]

General TransitM; -; 0-1; trigger=yes;

Features [?]

From: SUCA_PIG (O19069)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     64     67       Coenzyme A binding     T-G-x(2)  
REGION     143     145       Coenzyme A binding     [IVL]-T-[ED]  
ACT_SITE     299     299       Tele-phosphohistidine intermediate     H  
BINDING     90     90       Coenzyme A     K  
BINDING     207     207       Substrate; shared with subunit beta     Y  

Additional information [?]

Size range 299-347 amino acids
Related rules None
Fusion None