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HAMAP rule MF_03226

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General rule information [?]

Accession MF_03226
Dates 19-DEC-2018 (Created)
19-NOV-2022 (Last updated, Version 6)
Name YJU2
Scope(s) Eukaryota
Template(s) P28320 (YJU2_YEAST); Q9BW85 (YJU2_HUMAN); A8WHR3 (YJU2_DANRE); Q9P7C5 (YJU2_SCHPO); [ Recover all ]
Triggered by HAMAP; MF_03226 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier YJU2
Protein name RecName: Full=Splicing factor YJU2;
case <OC:Saccharomycetales> or <OC:Vertebrata>
Gene name Name=YJU2;
end case

Comments [?]

case <OC:Saccharomycetales>
FUNCTIONPart of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'- intermediates. Further stabilizes spliceosome conformation for 3'- splice site docking (via C-terminus) promoting exon ligation.
else case <OC:Vertebrata>
FUNCTIONPart of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.
else
FUNCTIONPart of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
end case
SUBUNITComponent of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
SUBCELLULAR LOCATIONNucleus.
SIMILARITYBelongs to the CWC16 family. YJU2 subfamily.

Keywords [?]

Nucleus
Spliceosome
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0071006; Cellular component:U2-type catalytic step 1 spliceosome
GO:0000349; Biological process:generation of catalytic spliceosome for first transesterification step
case <OCellular component:Saccharomycetales>
GO:0071007; Cellular component:U2-type catalytic step 2 spliceosome
GO:0000350; Biological process:generation of catalytic spliceosome for second transesterification step
end case

Cross-references [?]

Pfam PF04502; DUF572; 1;

Features [?]

From: YJU2_YEAST (P28320)
Key From To Description Tag Condition FTGroup
BINDING 51 51 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 54 54 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 88 88 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 91 91 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1

Additional information [?]

Size range 270-345 amino acids
Related rules None
Fusion Nter: None Cter: None



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