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Annotation rule MF_03226 |
General rule information
[?]
Accession |
MF_03226 |
Dates |
19-DEC-2018 (Created) 20-NOV-2019 (Last updated, Version 4) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
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Full=Splicing factor YJU2;
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case <OC:Saccharomycetales> or <OC:Vertebrata>
end case
case <OC:Saccharomycetales>
Function |
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation. |
else case <OC:Vertebrata>
Function |
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. |
else
Function |
Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. |
end case
Subunit |
Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron. |
Subcellular location |
Nucleus. |
Similarity |
Belongs to the CWC16 family. YJU2 subfamily. |
case <FTGroup:1>
end case
GO:0071006; Cellular component: U2-type catalytic step 1 spliceosome.
GO:0000349; Biological process: generation of catalytic spliceosome for first transesterification step.
case <OC:Saccharomycetales>
GO:0071007; Cellular component: U2-type catalytic step 2 spliceosome.
GO:0000350; Biological process: generation of catalytic spliceosome for second transesterification step.
end case
From: YJU2_YEAST (P28320) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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METAL
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51
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51
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Zinc
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C
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1
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METAL
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54
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54
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Zinc
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C
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1
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METAL
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88
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88
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Zinc
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C
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1
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METAL
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91
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91
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Zinc
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C
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1
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Additional information
[?]
Size range |
270-345 amino acids |
Related rules |
None |
Fusion |
None |