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Annotation rule MF_03226
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General rule information [?]

Accession MF_03226
Dates 19-DEC-2018 (Created)
20-NOV-2019 (Last updated, Version 4)
Name YJU2
Scope
Eukaryota
Templates P28320 (YJU2_YEAST); Q9BW85 (YJU2_HUMAN); A8WHR3 (YJU2_DANRE); Q9P7C5 (YJU2_SCHPO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
YJU2
Protein name
RecName: Full=Splicing factor YJU2;
case <OC:Saccharomycetales> or <OC:Vertebrata>
Gene name
YJU2
end case

Comments [?]

case <OC:Saccharomycetales>
Function Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation.
else case <OC:Vertebrata>
Function Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.
else
Function Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates.
end case
Subunit Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
Subcellular location Nucleus.
Similarity Belongs to the CWC16 family. YJU2 subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0071006; Cellular component: U2-type catalytic step 1 spliceosome.
GO:0000349; Biological process: generation of catalytic spliceosome for first transesterification step.
case <OC:Saccharomycetales>
GO:0071007; Cellular component: U2-type catalytic step 2 spliceosome.
GO:0000350; Biological process: generation of catalytic spliceosome for second transesterification step.
end case

Cross-references [?]

Pfam PF04502; DUF572; 1;

Features [?]

From: YJU2_YEAST (P28320)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     51     51       Zinc     C   1
METAL     54     54       Zinc     C   1
METAL     88     88       Zinc     C   1
METAL     91     91       Zinc     C   1

Additional information [?]

Size range 270-345 amino acids
Related rules None
Fusion None