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Annotation rule MF_04046
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General rule information [?]

Accession MF_04046
Dates 10-NOV-2016 (Created)
20-NOV-2019 (Last updated, Version 6)
Name HSV_UNG
Scope
Viruses; Herpesviridae
Templates P10186 (UNG_HHV11); P12295 (UNG_ECOLI): [Recover all]
case <OC:Herpesviridae>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UNG
Protein name
RecName: Full=Uracil-DNA glycosylase;
Short=UDG;
EC 3.2.2.27;
AltName: Full=UNG;

Comments [?]

Function Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.
Catalytic activity Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27;
Subcellular location Host nucleus.
Similarity Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.

Keywords [?]


Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0004844; Molecular function: uracil DNA N-glycosylase activity.
GO:0006284; Biological process: base-excision repair.

Cross-references [?]

PROSITE PS00130; U_DNA_GLYCOSYLASE; 1;
Pfam PF03167; UDG; 1;
TIGRFAMs TIGR00628; ung; 1;

Features [?]

From: UNG_ECOLI (P12295)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     64     64       Proton acceptor     D  

Additional information [?]

Size range 204-362 amino acids
Related rules None
Fusion None