HAMAP rule MF_04055
General rule information
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| Accession | MF_04055 |
| Dates | 14-MAR-2017 (Created)
3-MAY-2022 (Last updated, Version 6) |
| Name | ADV_DPOL |
| Scope(s) |
Viruses Adenoviridae |
| Template(s) | P04495 (DPOL_ADE05); [ Recover all ] |
| Triggered by |
HAMAP; MF_04055 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DPOL |
| Protein name | RecName: Full=DNA polymerase; EC=2.7.7.7; |
| Gene name | Name=POL; |
Comments
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| FUNCTION | Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis. |
| CATALYTIC ACTIVITY | Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339, Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:173112; EC=2.7.7.7; |
| SUBUNIT | Heterodimer with the terminal protein; this heterodimer binds to bp 9 to 18 of the genome. Forms a complex with viral pTP, DBP and hosts NFIA and POU2F1/OCT1 for initiation of replication. |
| SUBCELLULAR LOCATION | Host nucleus. |
| MISCELLANEOUS | This DNA polymerase requires a protein as a primer. |
| SIMILARITY | Belongs to the DNA polymerase type-B family. |
Keywords
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| DNA replication |
| DNA-binding |
| DNA-directed DNA polymerase |
| Host nucleus |
| Nucleotidyltransferase |
| Transferase |
| Viral DNA replication |
Gene Ontology
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| GO:0042025; Cellular component:host cell nucleus |
| GO:0008408; Molecular function:3'-5' exonuclease activity |
| GO:0003677; Molecular function:DNA binding |
| GO:0003887; Molecular function:DNA-directed DNA polymerase activity |
| GO:0000166; Molecular function:nucleotide binding |
| GO:0006261; Biological process:DNA-templated DNA replication |
| GO:0039693; Biological process:viral DNA genome replication |
Cross-references
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| PROSITE | PS00116; DNA_POLYMERASE_B; 1; |
| Pfam | PF03175; DNA_pol_B_2; 1; |
| PRINTS | PR00106; DNAPOLB; 1; |
| PIRSF | PIRSF000788; DPol_ADV; 1; |
Features
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Additional information
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| Size range | 1017-1198 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |