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Annotation rule MF_04055
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General rule information [?]

Accession MF_04055
Dates 14-MAR-2017 (Created)
20-NOV-2019 (Last updated, Version 4)
Name ADV_DPOL
Scope
Viruses; Adenoviridae
Template P04495 (DPOL_ADE05)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DPOL
Protein name
RecName: Full=DNA polymerase;
EC 2.7.7.7;
Gene name
POL

Comments [?]

Function Eukaryotic-type DNA polymerase involved in viral genomic replication. DNA synthesis is protein primed, and acts in a strand displacement replication. Assembles in complex with viral pTP, DBP, host NFIA and host POU2F1/OCT1 on viral origin of replication. The polymerase covalently transfers dCMP onto pTP, thereby initiating complementary strand synthesis.
Catalytic activity RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
EC 2.7.7.7
Subunit Heterodimer with the terminal protein; this heterodimer binds to bp 9 to 18 of the genome. Forms a complex with viral pTP, DBP and hosts NFIA and POU2F1/OCT1 for initiation of replication.
Subcellular location Host nucleus.
Miscellaneous This DNA polymerase requires a protein as a primer.
Similarity Belongs to the DNA polymerase type-B family.

Keywords [?]


Gene Ontology [?]

GO:0042025; Cellular component: host cell nucleus.
GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000166; Molecular function: nucleotide binding.
GO:0006261; Biological process: DNA-dependent DNA replication.
GO:0039693; Biological process: viral DNA genome replication.

Cross-references [?]

PROSITE PS00116; DNA_POLYMERASE_B; 1;
Pfam PF03175; DNA_pol_B_2; 1;
PRINTS PR00106; DNAPOLB; 1;
PIRSF PIRSF000788; DPol_ADV; 1;

Additional information [?]

Size range 1017-1198 amino acids
Related rules None
Fusion None