HAMAP rule MF_04094

General rule information [?]

Accession	MF_04094
Dates	9-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3)
Name	ROTA_A_NSP3
Scope(s)	Viruses Rotavirus
Template(s)	Q8UZL8 (NSP3_ROTRH); [ Recover all ]
Triggered by	HAMAP; MF_04094 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NSP3
Protein name	RecName: Full=Non-structural protein 3; Short=NSP3; AltName: Full=NCVP4; AltName: Full=Non-structural RNA-binding protein 34; Short=NS34;

Comments [?]

FUNCTION	Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
SUBUNIT	Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1.
SUBCELLULAR LOCATION	Host cytoplasm.
SIMILARITY	Belongs to the rotavirus A NSP3 protein family.

Keywords [?]

Gene Ontology [?]

GO:0003723; Molecular function:RNA binding

GO:0006417; Biological process:regulation of translation

Cross-references [?]

Features [?]

From: NSP3_ROTRH (Q8UZL8)

Key

From

Description

Tag

Condition

FTGroup

REGION

Nter

149

/note="RNA-binding"

REGION

150

206

/note="Dimerization"

REGION

170

234

/note="Interaction with host ZC3H7B"

REGION

208

Cter

/note="Interaction with host EIF4G1"

COILED

166

237

Additional information [?]