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Annotation rule MF_04094
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General rule information [?]

Accession MF_04094
Dates 9-MAR-2018 (Created)
20-NOV-2019 (Last updated, Version 3)
Name ROTA_A_NSP3
Scope
Viruses; Rotavirus
Template Q8UZL8 (NSP3_ROTRH)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
NSP3
Protein name
RecName: Full=Non-structural protein 3;
Short=NSP3;
AltName: Full=NCVP4;
AltName: Full=Non-structural RNA-binding protein 34;
Short=NS34;

Comments [?]

Function Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation.
Subunit Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1.
Subcellular location Host cytoplasm.
Similarity Belongs to the rotavirus A NSP3 protein family.

Keywords [?]

Coiled coil
Host cytoplasm
Host-virus interaction
RNA-binding
Translation regulation

Gene Ontology [?]

GO:0003723; Molecular function: RNA binding.
GO:0006417; Biological process: regulation of translation.

Cross-references [?]

PROSITE PS50137; DS_RBD; 1;
Pfam PF01665; Rota_NSP3; 1;
PF00035; dsrm; 1;

Features [?]

From: NSP3_ROTRH (Q8UZL8)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     149       RNA-binding        
REGION     150     206       Dimerization        
REGION     170     234       Interaction with host ZC3H7B        
REGION     208     Cter       Interaction with host EIF4G1        
COILED     166     237                

Additional information [?]

Size range 310-315 amino acids
Related rules MF_04090 (NSP3)
Fusion None


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