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Annotation rule MF_04094 |
Accession | MF_04094 |
Dates | 9-MAR-2018 (Created) 20-NOV-2019 (Last updated, Version 3) |
Name | ROTA_A_NSP3 |
Scope | Viruses; Rotavirus |
Template | Q8UZL8 (NSP3_ROTRH) |
Triggered by |
Identifier |
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Protein name |
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Function | Plays an important role in stimulating the translation of viral mRNAs. These mRNAs are capped but not polyadenylated, instead terminating in a conserved sequence 'GACC' at the 3' that is recognized by NSP3, which competes with host PABPC1 for EIF4G1 binding. The interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1 interaction, thereby facilitating the initiation of capped mRNA translation. |
Subunit | Homodimer. Interacts (via the coiled-coil region) with host ZC3H7B (via LD motif). Interacts with host EIF4G1. |
Subcellular location | Host cytoplasm. |
Similarity | Belongs to the rotavirus A NSP3 protein family. |
From: NSP3_ROTRH (Q8UZL8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 149 | RNA-binding | |||||||||
REGION | 150 | 206 | Dimerization | |||||||||
REGION | 170 | 234 | Interaction with host ZC3H7B | |||||||||
REGION | 208 | Cter | Interaction with host EIF4G1 | |||||||||
COILED | 166 | 237 |
Size range | 310-315 amino acids |
Related rules | MF_04090 (NSP3) |
Fusion | None |