HAMAP rule MF_04101
General rule information
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Accession | MF_04101 |
Dates | 28-JUN-2016 (Created) 19-NOV-2022 (Last updated, Version 8) |
Name | DPOL_T7 |
Scope | Viruses; Caudoviricetes |
Template | P00581 (DPOL_BPT7) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Comments
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Function | Replicates viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. |
Catalytic activity | RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
EC 2.7.7.7 |
Cofactor | Mg(2+) |
Similarity | Belongs to the DNA polymerase type-A family. |
Keywords
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DNA replication
DNA-binding
DNA-directed DNA polymerase
Exonuclease
Hydrolase
Magnesium
Metal-binding
Multifunctional enzyme
Nuclease
Nucleotidyltransferase
Transferase
Viral DNA replication
DNA-binding
DNA-directed DNA polymerase
Exonuclease
Hydrolase
Magnesium
Metal-binding
Multifunctional enzyme
Nuclease
Nucleotidyltransferase
Transferase
Viral DNA replication
Gene Ontology
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GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000166; Molecular function: nucleotide binding.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000166; Molecular function: nucleotide binding.
Cross-references
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Features
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From: DPOL_BPT7 (P00581) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 1 | 187 | 3'-5'exonuclease | |||||||||
REGION | 202 | Cter | Polymerase | |||||||||
BINDING | 5 | 5 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="1" /ligand_note="catalytic; for 3'-5' exonuclease activity | D | ||||||||
BINDING | 5 | 5 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" /ligand_note="catalytic; for 3'-5' exonuclease activity | D | ||||||||
BINDING | 7 | 7 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" /ligand_note="catalytic; for 3'-5' exonuclease activity | E | ||||||||
BINDING | 174 | 174 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="2" /ligand_note="catalytic; for 3'-5' exonuclease activity | D | ||||||||
BINDING | 475 | 475 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3" /ligand_note="catalytic; for polymerase activity | D | ||||||||
BINDING | 475 | 475 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="4" /ligand_note="catalytic; for polymerase activity | D | ||||||||
BINDING | 476 | 476 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="4" /ligand_note="catalytic; for polymerase activity | A | ||||||||
BINDING | 654 | 654 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="3" /ligand_note="catalytic; for polymerase activity | D | ||||||||
BINDING | 654 | 654 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="4" /ligand_note="catalytic; for polymerase activity | D | ||||||||
BINDING | 506 | 506 | /ligand="substrate | H | ||||||||
BINDING | 518 | 518 | /ligand="substrate | R | ||||||||
BINDING | 522 | 522 | /ligand="substrate | K | ||||||||
BINDING | 526 | 526 | /ligand="substrate | Y |
Additional information
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Size range | 614-904 amino acids |
Related rules | None |
Fusion | None |