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Annotation rule MF_04101
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General rule information [?]

Accession MF_04101
Dates 28-JUN-2016 (Created)
20-NOV-2019 (Last updated, Version 4)
Name DPOL_T7
Scope
Viruses; Caudovirales
Template P00581 (DPOL_BPT7)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DPOL
Protein name
RecName: Full=DNA-directed DNA polymerase;
EC 2.7.7.7;
EC 3.1.11.-;

Comments [?]

Function Replicates viral genomic DNA. This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
Catalytic activity RHEA:22508: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)
EC 2.7.7.7
Cofactor Mg(2+)
Similarity Belongs to the DNA polymerase type-A family.

Keywords [?]

DNA replication
DNA-binding
DNA-directed DNA polymerase
Exonuclease
Hydrolase
Magnesium
Metal-binding
Multifunctional enzyme
Nuclease
Nucleotidyltransferase
Transferase
Viral DNA replication

Gene Ontology [?]

GO:0008408; Molecular function: 3'-5' exonuclease activity.
GO:0003677; Molecular function: DNA binding.
GO:0003887; Molecular function: DNA-directed DNA polymerase activity.
GO:0000166; Molecular function: nucleotide binding.

Cross-references [?]

PROSITE PS00447; DNA_POLYMERASE_A; 1;
Pfam PF00476; DNA_pol_A; 1;
PF01612; DNA_pol_A_exo1; 1;

Features [?]

From: DPOL_BPT7 (P00581)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     1     187       3'-5'exonuclease        
REGION     202     Cter       Polymerase        
METAL     5     5       Magnesium 1; catalytic; for 3'-5' exonuclease activity     D  
METAL     5     5       Magnesium 2; catalytic; for 3'-5' exonuclease activity     D  
METAL     7     7       Magnesium 2; catalytic; for 3'-5' exonuclease activity     E  
METAL     174     174       Magnesium 2; catalytic; for 3'-5' exonuclease activity     D  
METAL     475     475       Magnesium 3; catalytic; for polymerase activity     D  
METAL     475     475       Magnesium 4; catalytic; for polymerase activity     D  
METAL     476     476       Magnesium 4; catalytic; via carbonyl oxygen; for polymerase activity     A  
METAL     654     654       Magnesium 3; catalytic; for polymerase activity     D  
METAL     654     654       Magnesium 4; catalytic; for polymerase activity     D  
BINDING     506     506       Substrate     H  
BINDING     518     518       Substrate     R  
BINDING     522     522       Substrate     K  
BINDING     526     526       Substrate     Y  

Additional information [?]

Size range 614-904 amino acids
Related rules None
Fusion None


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