HAMAP rule MF_04108
General rule information
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| Accession | MF_04108 |
| Dates | 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 7) |
| Name | HOLIN_T7 |
| Scope(s) |
Viruses Caudoviricetes |
| Template(s) | P03802 (HOLIN_BPT7); [ Recover all ] |
| Triggered by |
HAMAP; MF_04108 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HOLIN |
| Protein name | RecName: Full=Holin; |
Comments
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| FUNCTION | Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron- scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Participates in determining the precise timing of host cell lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell. |
| SUBUNIT | Homomultimer. |
| SUBCELLULAR LOCATION | Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Classified as a class II holin although it seems to have only one transmembrane domain. |
| SIMILARITY | Belongs to the T7likevirus holin family. |
Keywords
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| Cytolysis |
| Host cell inner membrane |
| Host cell lysis by virus |
| Host cell membrane |
| Host membrane |
| Membrane |
| Signal-anchor |
| Transmembrane |
| Transmembrane helix |
| Viral release from host cell |
Gene Ontology
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| GO:0019835; Biological process:cytolysis |
| GO:0140911; Molecular function:pore-forming activity |
| GO:0016020; Cellular component:membrane |
| GO:0020002; Cellular component:host cell plasma membrane |
| GO:0019076; Biological process:viral release from host cell |
Cross-references
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| Pfam | PF10746; Phage_holin_2_2; 1; |
Features
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| From: HOLIN_BPT7 (P03802) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 36 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 37 | 55 | /note="Helical; Signal-anchor for type II membrane protein" | |||||||||
| TOPO_DOM | 56 | Cter | /note="Periplasmic" | |||||||||
Additional information
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| Size range | 63-75 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |