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HAMAP rule MF_04108

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General rule information [?]

Accession MF_04108
Dates 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 7)
Scope(s) Viruses
Template(s) P03802 (HOLIN_BPT7); [ Recover all ]
Triggered by HAMAP; MF_04108 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HOLIN
Protein name RecName: Full=Holin;

Comments [?]

FUNCTIONAccumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron- scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Participates in determining the precise timing of host cell lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
SUBCELLULAR LOCATIONHost cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Classified as a class II holin although it seems to have only one transmembrane domain.
SIMILARITYBelongs to the T7likevirus holin family.

Keywords [?]

Gene Ontology [?]

GO:0019835; Biological process:cytolysis
GO:0140911; Molecular function:pore-forming activity
GO:0016020; Cellular component:membrane
GO:0020002; Cellular component:host cell plasma membrane
GO:0019076; Biological process:viral release from host cell

Cross-references [?]

Pfam PF10746; Phage_holin_2_2; 1;

Features [?]

From: HOLIN_BPT7 (P03802)
Key From To Description Tag Condition FTGroup
TOPO_DOM Nter 36 /note="Cytoplasmic"
TRANSMEM 37 55 /note="Helical; Signal-anchor for type II membrane protein"
TOPO_DOM 56 Cter /note="Periplasmic"

Additional information [?]

Size range 63-75 amino acids
Related rules None
Fusion Nter: None Cter: None

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