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HAMAP rule MF_04108

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General rule information [?]

Accession MF_04108
Dates 18-OCT-2016 (Created)
1-DEC-2022 (Last updated, Version 7)
Viruses; Caudoviricetes
Template P03802 (HOLIN_BPT7)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Holin;

Comments [?]

Function Accumulates harmlessly in the cytoplasmic membrane until it reaches a critical concentration that triggers the formation of micron-scale pores (holes) causing host cell membrane disruption and endolysin escape into the periplasmic space. Participates in determining the precise timing of host cell lysis. Participates with the endolysin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles from the host cell.
Subunit Homomultimer.
Subcellular location Host cell inner membrane; Single-pass type II membrane protein; Periplasmic side. Note=Classified as a class II holin although it seems to have only one transmembrane domain.
Similarity Belongs to the T7likevirus holin family.

Keywords [?]

Gene Ontology [?]

GO:0019835; Biological process: cytolysis.
GO:0140911; Molecular function: pore-forming activity.
GO:0016020; Cellular component: membrane.
GO:0020002; Cellular component: host cell plasma membrane.
GO:0019076; Biological process: viral release from host cell.

Cross-references [?]

Pfam PF10746; Phage_holin_2_2; 1;

Features [?]

From: HOLIN_BPT7 (P03802)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     36       Cytoplasmic        
TRANSMEM     37     55       Helical; Signal-anchor for type II membrane protein        
TOPO_DOM     56     Cter       Periplasmic        

Additional information [?]

Size range 63-75 amino acids
Related rules None
Fusion None