HAMAP rule MF_04138
General rule information
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Accession | MF_04138 |
Dates | 17-MAY-2019 (Created)
1-JUN-2023 (Last updated, Version 5) |
Name | TMP_LAMBDA |
Scope(s) |
Viruses |
Template(s) | P03736 (TMP_LAMBD); [ Recover all ] |
Triggered by |
HAMAP; MF_04138 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | TMP |
case <OC:Lambdavirus> | |
Protein name | RecName: Full=Tape measure protein; Short=TMP; AltName: Full=Gene product H; Short=gpH; AltName: Full=Minor tail protein H; Contains: RecName: Full=Entry protein H*; |
Gene name | Name=H; |
else | |
Protein name | RecName: Full=Tape measure protein; Short=TMP; |
end case |
Comments
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case <OC:Lambdavirus> | |
FUNCTION | Serves as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a six-stranded coil of alpha-helices and stabilized by the covering tail assembly proteins G and GT. Its C-terminus fixes the tail tip complex (J, I, L, K), thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tape measure protein, displacing the tail assembly proteins G and GT. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein. Upon tail assembly, tape measure protein is cleaved into a form called H*, that plays a role later during virion entry in a new cell. Once assembled, the virion is released and can infect new cell by binding to the entry receptor. After opening of a pore on the external membrane, the entry protein H* protein is probably released in the periplasmic space for successfull DNA injection. |
SUBUNIT | Interacts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly protein G. Interacts with the tail assembly protein GT. |
SUBCELLULAR LOCATION | Virion. Note=There are 6 copies of entry protein H* per mature phage. |
PTM | Cleaved into mature protein H* by an unidentified protease. |
else | |
FUNCTION | Serves as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a coil of alpha-helices and stabilized by the covering tail assembly proteins. Its C-terminus fixes the tail tip complex, thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tail measure protein, displacing the tail assembly proteins. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein. |
SUBUNIT | Interacts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly proteins. |
SUBCELLULAR LOCATION | Virion. |
end case | |
SIMILARITY | Belongs to the Lambdavirus tape measure protein family. |
Keywords
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Gene Ontology
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GO:0098003; Biological process:viral tail assembly |
GO:0098015; Cellular component:virus tail |
Cross-references
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Pfam | PF09718; Tape_meas_lam_C; 1; |
Pfam | PF06791; TMP_2; 1; |
NCBIfam | TIGR01541; tape_meas_lam_C; 1; |
General | Coiled_coil; -; 0-unlimited; |
Features
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From: TMP_LAMBD (P03736) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
CHAIN | Nter | Cter | /note="Tape measure protein" | |||||||||
case <OC:Lambdavirus> | ||||||||||||
CHAIN | ? | Cter | /note="Entry protein H*" | |||||||||
end case |
Additional information
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Size range | 800-1200 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |