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HAMAP rule MF_04138

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General rule information [?]

Accession MF_04138
Dates 17-MAY-2019 (Created)
1-JUN-2023 (Last updated, Version 5)
Name TMP_LAMBDA
Scope
Viruses
Template P03736 (TMP_LAMBD)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TMP
case <OC:Lambdavirus>
Protein name
RecName: Full=Tape measure protein;
Short=TMP;
AltName: Full=Gene product H;
Short=gpH;
AltName: Full=Minor tail protein H;
Contains:
RecName: Full=Entry protein H*;
Gene name
H
else
Protein name
RecName: Full=Tape measure protein;
Short=TMP;
end case

Comments [?]

case <OC:Lambdavirus>
Function Serves as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a six-stranded coil of alpha-helices and stabilized by the covering tail assembly proteins G and GT. Its C-terminus fixes the tail tip complex (J, I, L, K), thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tape measure protein, displacing the tail assembly proteins G and GT. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein. Upon tail assembly, tape measure protein is cleaved into a form called H*, that plays a role later during virion entry in a new cell. Once assembled, the virion is released and can infect new cell by binding to the entry receptor. After opening of a pore on the external membrane, the entry protein H* protein is probably released in the periplasmic space for successfull DNA injection.
Subunit Interacts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly protein G. Interacts with the tail assembly protein GT.
Subcellular location Virion. Note=There are 6 copies of entry protein H* per mature phage.
Ptm Cleaved into mature protein H* by an unidentified protease.
else
Function Serves as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a coil of alpha-helices and stabilized by the covering tail assembly proteins. Its C-terminus fixes the tail tip complex, thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tail measure protein, displacing the tail assembly proteins. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein.
Subunit Interacts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly proteins.
Subcellular location Virion.
end case
Similarity Belongs to the Lambdavirus tape measure protein family.

Keywords [?]

Viral genome ejection through host cell envelope
case <OC:Lambdavirus>
Viral long flexible tail ejection system
end case
Viral penetration into host cytoplasm
Viral release from host cell
Viral tail assembly
Viral tail protein
Virion
Virus entry into host cell

Gene Ontology [?]

GO:0098003; Biological process: viral tail assembly.
GO:0098015; Cellular component: virus tail.

Cross-references [?]

Pfam PF09718; Tape_meas_lam_C; 1;
PF06791; TMP_2; 1;
NCBIfam TIGR01541; tape_meas_lam_C; 1;

Computed features [?]

General Coiled_coil; -; 0-unlimited; trigger=yes;

Features [?]

From: TMP_LAMBD (P03736)
Key     From     To       Description   Tag   Condition   FTGroup
CHAIN     Nter     Cter       Tape measure protein        
case <OC:Lambdavirus>
CHAIN     ?     Cter       Entry protein H*        
end case

Additional information [?]

Size range 800-1200 amino acids
Related rules None
Fusion None


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