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HAMAP rule MF_04138

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General rule information [?]

Accession MF_04138
Dates 17-MAY-2019 (Created)
1-JUN-2023 (Last updated, Version 5)
Name TMP_LAMBDA
Scope(s) Viruses
Template(s) P03736 (TMP_LAMBD); [ Recover all ]
Triggered by HAMAP; MF_04138 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TMP
case <OC:Lambdavirus>
Protein name RecName: Full=Tape measure protein;
                 Short=TMP;
AltName: Full=Gene product H;
                 Short=gpH;
AltName: Full=Minor tail protein H;
                 Contains:
RecName: Full=Entry protein H*;
Gene name Name=H;
else
Protein name RecName: Full=Tape measure protein;
                 Short=TMP;
end case

Comments [?]

case <OC:Lambdavirus>
FUNCTIONServes as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a six-stranded coil of alpha-helices and stabilized by the covering tail assembly proteins G and GT. Its C-terminus fixes the tail tip complex (J, I, L, K), thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tape measure protein, displacing the tail assembly proteins G and GT. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein. Upon tail assembly, tape measure protein is cleaved into a form called H*, that plays a role later during virion entry in a new cell. Once assembled, the virion is released and can infect new cell by binding to the entry receptor. After opening of a pore on the external membrane, the entry protein H* protein is probably released in the periplasmic space for successfull DNA injection.
SUBUNITInteracts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly protein G. Interacts with the tail assembly protein GT.
SUBCELLULAR LOCATIONVirion. Note=There are 6 copies of entry protein H* per mature phage.
PTMCleaved into mature protein H* by an unidentified protease.
else
FUNCTIONServes as a ruler that controls the length of tail by stopping the tail tube polymerization and is probably released from the tail shaft during infection to facilitate DNA translocation into the host cell. Assembles into a multimeric linear form probably arranged as a coil of alpha-helices and stabilized by the covering tail assembly proteins. Its C-terminus fixes the tail tip complex, thereby forming the tail assembly initiator complex. Tail tube proteins polymerize around the tail measure protein, displacing the tail assembly proteins. When the tail reaches the length specified by the tape measure protein, it stops and becomes capped by the tail terminator protein.
SUBUNITInteracts with the tail initiator complex presumably through its C-terminus domain. Interacts with the tail assembly proteins.
SUBCELLULAR LOCATIONVirion.
end case
SIMILARITYBelongs to the Lambdavirus tape measure protein family.

Keywords [?]


Gene Ontology [?]

GO:0098003; Biological process:viral tail assembly
GO:0098015; Cellular component:virus tail

Cross-references [?]

Pfam PF09718; Tape_meas_lam_C; 1;
Pfam PF06791; TMP_2; 1;
NCBIfam TIGR01541; tape_meas_lam_C; 1;
General Coiled_coil; -; 0-unlimited;

Features [?]

From: TMP_LAMBD (P03736)
Key From To Description Tag Condition FTGroup
CHAIN Nter Cter /note="Tape measure protein"
case <OC:Lambdavirus>
CHAIN ? Cter /note="Entry protein H*"
end case

Additional information [?]

Size range 800-1200 amino acids
Related rules None
Fusion Nter: None Cter: None



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