HAMAP rule MF_00057
General rule information
[?]
| Accession | MF_00057 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | KdsB |
| Scope(s) |
Bacteria |
| Template(s) | P04951 (KDSB_ECOLI); P42216 (KPSU5_ECOLX); Q8EEA9 (KDSB_SHEON); [ Recover all ] |
| Triggered by |
HAMAP; MF_00057 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | KDSB |
| case <OC:Shewanella> | |
| Protein name | RecName: Full=8-amino-3,8-dideoxy-manno-octulosonate cytidylyltransferase; EC=2.7.7.90; AltName: Full=CMP-8-amino-3,8-dideoxy-manno-octulosonate synthase; |
| else | |
| Protein name | RecName: Full=3-deoxy-manno-octulosonate cytidylyltransferase; EC=2.7.7.38; AltName: Full=CMP-2-keto-3-deoxyoctulosonic acid synthase; Short=CKS; Short=CMP-KDO synthase; |
| end case | |
| Gene name | Name=kdsB; |
Comments
[?]
| case <OC:Shewanella> | |
| FUNCTION | Activates KDO8N (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in the Shewanella genus. |
| CATALYTIC ACTIVITY | Reaction=8-amino-3,8-dideoxy-alpha-D-manno-octulosonate + CTP = CMP-8- amino-3,8-dideoxy-alpha-D-manno-oct-2-ulosonate + diphosphate; Xref=Rhea:RHEA:49284, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:87091, ChEBI:CHEBI:91089; EC=2.7.7.90; |
| else | |
| FUNCTION | Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. |
| CATALYTIC ACTIVITY | Reaction=3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy- beta-D-manno-octulosonate + diphosphate; Xref=Rhea:RHEA:23448, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:85986, ChEBI:CHEBI:85987; EC=2.7.7.38; |
| PATHWAY | Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno- octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3- deoxy-D-manno-octulosonate and CTP: step 1/1. |
| end case | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| end case | |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the KdsB family. |
Keywords
[?]
Gene Ontology
[?]
| case <OCellular component:Shewanella> | |
| GO:0016779; Molecular function:nucleotidyltransferase activity | |
| else; https://www.ebi.ac.uk/QuickGO/term/else | |
| GO:0008690; Molecular function:3-deoxy-manno-octulosonate cytidylyltransferase activity | |
| GO:0033468; Biological process:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process | |
| end case | |
| GO:0009103; Biological process:lipopolysaccharide biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
[?]
| NCBIfam | TIGR00466; KdsB; 1; |
Features
[?]
Additional information
[?]
| Size range | 230-310 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | kpsU from E.coli (KPSU5_ECOLX) is not a duplicate, but a kdsB from a non-K12 strain. Kdo8N is found in lipopolysaccharides of members of the Shewanella genus. (PubMed:23413030) |