HAMAP rule MF_00077
General rule information
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| Accession | MF_00077 |
| Dates | 1-JUN-2001 (Created)
1-JUN-2023 (Last updated, Version 33) |
| Name | tRNA_methyltr_aTrm56 |
| Scope(s) |
Archaea |
| Template(s) | O58214 (TRM56_PYRHO); Q9UYD1 (TRM56_PYRAB); O29507 (TRM56_ARCFU); [ Recover all ] |
| Triggered by |
HAMAP; MF_00077 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TRM56 |
| Protein name | RecName: Full=tRNA (cytidine(56)-2'-O)-methyltransferase; EC=2.1.1.206; AltName: Full=tRNA ribose 2'-O-methyltransferase aTrm56; |
Comments
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| FUNCTION | Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. |
| CATALYTIC ACTIVITY | Reaction=cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O- methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42968, Rhea:RHEA-COMP:10308, Rhea:RHEA-COMP:10309, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.206; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the aTrm56 family. |
Keywords
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Gene Ontology
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| GO:0008175; Molecular function:tRNA methyltransferase activity |
| GO:0002128; Biological process:tRNA nucleoside ribose methylation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF01994; Trm56; 1; |
| Pfam | PF01966; HD; 0-1; |
| NCBIfam | TIGR00277; HDIG; 0-1; |
| PROSITE | PS51831; HD; 0-1; |
Features
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| From: TRM56_PYRHO (O58214) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 109 | 113 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
G-[GAS]-[ED]-[KR]-V | ||||||||
| BINDING | 127 | 134 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[VI]-[GAS]-N-Q-P-H-S-E | ||||||||
| BINDING | 80 | 80 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
L | ||||||||
Additional information
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| Size range | 168-218 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: <HD domain> |
| Comments | Shorter N-terminus in SULAC and SACS2. |